Vision and Objectives

The purpose of Industry Day is to exchange information with industry to increase understanding of the Government's current vision and objectives for the xEVA Production and Services Contract. The presentation provides industry with the opportunity to provide input into the xEVAPS procurement strategy and encourage offerors to submit questions and comments. A technical overview of the xEVA System serves as the foundation for the content related to draft requirements in the SOW

Exploring Actual Social Support Using the Social Convoy Model to Assess the Impact on Depression in Adolescents

The current study set out to better understand the differences between availability of support and received support and explore the relation between social support and depression in late adolescents. One hundred and forty participants were recruited from a northwest suburb high school and a college from the eastern central part of Illinois. A social network was formed for each participant using a mapping technique from the Social Convoy Model. The received support measure, the UCLA Social Support Inventory, was used to assess the amount of received support participants identified from their social network. Participants completed the Late Adolescent Social Support Inventory to measure availability of support and the Center for Epidemiologic Studies Depression Scale Revised to measure depression. The correlation between the CESD-R and the LASSI in both student samples were statistically significant; however other subscales for social network sizes and received subscales were inconsistently related to depression. A two (type of received support) by three (intimacy level) by two (sample; high school or college) repeated measure ANOVA was conducted on total received support and indicated significant main effects for level of intimacy and type of received support; as well as a significant 3-way interaction. Results from multiple stepwise regression analysis indicate that the LASSI was the best predictor of depression accounting for 29% of the high school variance and 21% of the college variance

The Indisputable Fact of the Baptism: The Problematic Consensus on John’s Baptism of Jesus

As there is now an emerging “Quest” for the historical John the Baptist, it is important to look at how previous quests have treated his baptism of Jesus. Often regarded as a virtually indisputable fact of history, the baptism is asserted almost blindly without any argumentation or with only a few minimal points in its favor. In this essay, the case for the baptism is briefly evaluated and found to be entirely lacking, hinged instead on problematic assumptions and errant uses of the criteria of authenticity. Disavowing these uses, there instead emerges a rather simple set of arguments in favor of the baptism being ahistorical. It is argued that we do not have enough evidence to find the baptism historical, which has drastic ramifications on those attempting to produce biographies of both Jesus and John

Direction of the Play: Another One

Another One Written and Directed by Chris Hansen, Spokane Falls Community College Theatre Department Produced November 2020 This project encompasses the selection, research, casting, production, and post-production process of the play, Another One, for Spokane Falls Community College Theatre Arts Department. Documentation includes: analysis of the play for our program, research, script analysis, scenic and technical challenges of our time, a record of the production period and a post-production evaluation

Multi-scale coarse-graining of diblock copolymer self-assembly: from monomers to ordered micelles

Starting from a microscopic lattice model, we investigate clustering, micellization and micelle ordering in semi-dilute solutions of AB diblock copolymers in a selective solvent. To bridge the gap in length scales, from monomers to ordered micellar structures, we implement a two-step coarse graining strategy, whereby the AB copolymers are mapped onto ``ultrasoft'' dumbells with monomer-averaged effective interactions between the centres of mass of the blocks. Monte Carlo simulations of this coarse-grained model yield clear-cut evidence for self-assembly into micelles with a mean aggregation number n of roughly 100 beyond a critical concentration. At a slightly higher concentration the micelles spontaneously undergo a disorder-order transition to a cubic phase. We determine the effective potential between these micelles from first principles.Comment: 4 pages, 4 figures, submitted to Phys. Rev. Lett

Parents' beliefs and knowledge about the management of acute otitis media: A qualitative study

BACKGROUND: Acute otitis media is a common reason for antibiotic prescribing, despite strong evidence that antibiotics provide minimal benefit. Studies have demonstrated that patients’ (or parents’) expectations of antibiotics often influence general practitioners’ (GPs) decision to prescribe antibiotics, but few have explored parents’ expectations of the management of infections in children, or which factors influence the development of these expectations. This study aimed to explore parents’ knowledge and beliefs about the management of acute otitis media in children. METHODS: Individual semi-structured interviews were conducted with 15 parents of children who had recently presented to their GP with acute otitis media. Parents were recruited at childcare centres or playgroups in Brisbane, Australia. RESULTS: Many parents did not have an accurate understanding of what causes acute otitis media. GPs were primarily consulted for the management of symptoms such as pain and fever. Others specifically wanted reassurance or were concerned about hearing loss. Most parents assumed that antibiotics were the best treatment option. Parents’ perceptions about the best treatment were mainly based on their previous experience and the advice of the GP. Pain relief medications, such as paracetamol and non-steroidal anti-inflammatory drugs, were not considered by parents to be sufficient treatment on their own. CONCLUSION: There is discrepancy between parents’ beliefs and expectations of management of acute otitis media and the evidence-based recommendations. This study provides insights into parents’ expectations of management of acute otitis media, which may help inform clinicians about perceptions and misperceptions that may be valuable to elicit and discuss

Generation of Lamprey Monoclonal Antibodies (Lampribodies) Using the Phage Display System.

The variable lymphocyte receptors (VLRs) consist of leucine rich repeats (LRRs) and comprise the humoral antibodies produced by lampreys and hagfishes. The diversity of the molecules is generated by stepwise genomic rearrangements of LRR cassettes dispersed throughout the VLRB locus. Previously, target-specific monovalent VLRB antibodies were isolated from sea lamprey larvae after immunization with model antigens. Further, the cloned VLR cDNAs from activated lamprey leukocytes were transfected into human cell lines or yeast to select best binders. Here, we expand on the overall utility of the VLRB technology by introducing it into a filamentous phage display system. We first tested the efficacy of isolating phage into which known VLRB molecules were cloned after a series of dilutions. These experiments showed that targeted VLRB clones could easily be recovered even after extensive dilutions (1 to 109). We further utilized the system to isolate target-specific "lampribodies" from phage display libraries from immunized animals and observed an amplification of binders with relative high affinities by competitive binding. The lampribodies can be individually purified and ostensibly utilized for applications for which conventional monoclonal antibodies are employed