„Sublokatorka” po latach. Z Hanną Krall rozmawiają Elżbieta Janicka i Joanna Tokarska-Bakir. Warszawa, 28 lutego i 8 marca 2013 roku

"Sublokatorka" now. An interview with Hanna Krall: Warsaw, 28 February and 28 March 2013 The interview was conducted by Elżbieta Janicka and Joanna Tokarska-Bakir. Hanna Krall told the story of the issues related to the publication of Sublokatorka, which finally appeared in the Paris-based printing house Libella, owned by Zofia and Kazimierz Romanowicz, in 1985. Hanna Krall also spoke about how the book was received by the public in the unofficial underground discourse in the Communist Poland. Moreover, the author of Sublokatorka told the interviewers about the construction of stories about the Holocaust, as well as about the people who inspired the protagonists of Sublokatorka: Luba Bielicka-Blum, Rywka Urman, Krystyna Krahelska, Krzysztof Kieślowski and Jerzy Stuhr.   „Sublokatorka” po latach. Z Hanną Krall rozmawiają Elżbieta Janicka i Joanna Tokarska-Bakir. Warszawa, 28 lutego i 8 marca 2013 roku Hanna Krall opowiada Elżbiecie Janickiej i Joannie Tokarskiej-Bakir o kłopotach z publikacją Sublokatorki, która ostatecznie ukazała się w paryskim wydawnictwie Zofii i Kazimierza Romanowiczów Libella w 1985 roku. Tematem rozmowy jest także burzliwy, niewolny od werbalnej agresji, odbiór książki w drugim, niezależnym obiegu kultury w PRL. W wywiadzie mowa ponadto o sposobach konstruowania i stawkach opowieści o Zagładzie, a także o pierwowzorach postaci z Sublokatorki takich jak: Luba Bielicka-Blum, Rywka Urman, Krystyna Krahelska, Krzysztof Kieślowski czy Jerzy Stuhr

Age and hippocampal volume predict distinct parts of default mode network activity

Group comparison studies have established that activity in the posterior part of the default-mode network (DMN) is down-regulated by both normal ageing and Alzheimer’s disease (AD). In this study linear regression models were used to disentangle distinctive DMN activity patterns that are more profoundly associated with either normal ageing or a structural marker of neurodegeneration. 312 datasets inclusive of healthy adults and patients were analysed. Days of life at scan (DOL) and hippocampal volume were used as predictors. Group comparisons confirmed a significant association between functional connectivity in the posterior cingulate/retrosplenial cortex and precuneus and both ageing and AD. Fully-corrected regression models revealed that DOL significantly predicted DMN strength in these regions. No such effect, however, was predicted by hippocampal volume. A significant positive association was found between hippocampal volumes and DMN connectivity in the right temporo-parietal junction (TPJ). These results indicate that postero-medial DMN down-regulation may not be specific to neurodegenerative processes but may be more an indication of brain vulnerability to degeneration. The DMN-TPJ disconnection is instead linked to the volumetric properties of the hippocampus, may reflect early-stage regional accumulation of pathology and might be of aid in the clinical detection of abnormal ageing

„Sublokatorka” po latach. Z Hanną Krall rozmawiają Elżbieta Janicka i Joanna Tokarska-Bakir. Warszawa, 28 lutego i 8 marca 2013 roku

"Sublokatorka" now. An interview with Hanna Krall: Warsaw, 28 February and 28 March 2013The interview was conducted by Elżbieta Janicka and Joanna Tokarska-Bakir. Hanna Krall told the story of the issues related to the publication of Sublokatorka, which finally appeared in the Paris-based printing house Libella, owned by Zofia and Kazimierz Romanowicz, in 1985. Hanna Krall also spoke about how the book was received by the public in the unofficial underground discourse in the Communist Poland. Moreover, the author of Sublokatorka told the interviewers about the construction of stories about the Holocaust, as well as about the people who inspired the protagonists of Sublokatorka: Luba Bielicka-Blum, Rywka Urman, Krystyna Krahelska, Krzysztof Kieślowski and Jerzy Stuhr. „Sublokatorka” po latach. Z Hanną Krall rozmawiają Elżbieta Janicka i Joanna Tokarska-Bakir. Warszawa, 28 lutego i 8 marca 2013 rokuHanna Krall opowiada Elżbiecie Janickiej i Joannie Tokarskiej-Bakir o kłopotach z publikacją Sublokatorki, która ostatecznie ukazała się w paryskim wydawnictwie Zofii i Kazimierza Romanowiczów Libella w 1985 roku. Tematem rozmowy jest także burzliwy, niewolny od werbalnej agresji, odbiór książki w drugim, niezależnym obiegu kultury w PRL. W wywiadzie mowa ponadto o sposobach konstruowania i stawkach opowieści o Zagładzie, a także o pierwowzorach postaci z Sublokatorki takich jak: Luba Bielicka-Blum, Rywka Urman, Krystyna Krahelska, Krzysztof Kieślowski czy Jerzy Stuhr

Synthesis and pharmacological evaluation of novel 10 -[2- (Difluoromethoxy)benzyl]-20 H,50 H-spiro[8-azabicyclo[3.2.1]- octane-3,40 -imidazolidine]-20 ,50 -diones and their derivatives

A series of novel 1′‐[2‐(difluoromethoxy)benzyl]‐2′H,5′H‐spiro[8‐azabicyclo[3.2.1]octane‐3,4′‐imidazolidine]‐2′,5′‐dione substituted hydantoins (5–32) were synthesized using an appropriate synthetic route and characterized by elemental analysis and spectral data. The novel molecules were screened for anticonvulsant activity in mice by maximal electroshock (MES) and subcutaneous pentylenetetrazol (ScPTZ)‐induced seizure tests. The neurotoxicity was assessed using the rotarod method. Compounds 9, 10, 18, 30, and 31 exhibited anticonvulsant potency against MES seizure and in the ScPTZ model, with lesser neurotoxicity. Some title compounds showed lesser central nervous system depression compared to phenytoin