Analysis of single-unit responses to emotional scenes in human ventromedial prefrontal cortex

Lesion and functional imaging studies in humans have shown that the ventral and medial prefrontal cortex is critically involved in the processing of emotional stimuli, but both of these methods have limited spatiotemporal resolution. Conversely, neurophysiological studies of emotion in nonhuman primates typically rely on stimuli that do not require elaborate cognitive processing. To begin bridging this gap, we recorded from a total of 267 neurons in the left and right orbital and anterior cingulate cortices of four patients who had chronically implanted depth electrodes for monitoring epilepsy. Peristimulus activity was recorded to standardized, complex visual scenes depicting neutral, pleasant, or aversive content. Recording locations were verified with postoperative magnetic resonance imaging. Using a conservative, multistep statistical evaluation, we found significant responses in 56 neurons; 16 of these were selective for only one emotion class, most often aversive. The findings suggest sparse and widely distributed processing of emotional value in the prefrontal cortex, with a predominance of responses to aversive stimuli

The Archaeology of a Manuscript : Huntington Library HM 266

Hanna III Ralph. The Archaeology of a Manuscript : Huntington Library HM 266. In: Scriptorium, Tome 36 n°1, 1982. pp. 99-102

Monstrous Words, Monstrous Bodies: Irony and the Walking Dead in Walter Map's De Nugis Curialium

This article analyses the function of the tales of the walking dead found in Distinction II of Walter Map's De Nugis Curialium (c.1182). Map's sole surviving work, the “Courtiers’ Trifles” is a collection of historical narratives, wonder stories, witty asides and anecdotes collated during his employment at Henry II's court. The satirical nature of the De Nugis has been noted by previous scholars; however, this has yet to be discussed specifically with regard to the tales of the undead. Following a discussion of the twelfth-century traditions of satirical literature and the ways in which medieval authors approached the trope of irony, the second part of the narrative will examine how Map, a master of the “art of lying”, deconstructed the conventions of wonder stories. It will be argued that as well as using these tales to satirise the historiographical function of mirabilia, they were also used to critique the reality of court life and, on a deeper level, the literary function of ambiguity itself. The inherent irony of the walking dead, the dissonance between physical form and metaphysical intent, meant that they could be inscribed with multiple, parallel meanings

Inclusive heavy-flavour production at central and forward rapidity in Xe–Xe collisions at sNN\sqrt{s_{\rm NN}} = 5.44 TeV

The first measurements of the production of muons and electrons from heavy-flavour hadron decays in Xe–Xe collisions at $\sqrt{s_{\rm NN}}$ = 5.44 TeV, using the ALICE detector at the LHC, are reported. The measurement of the nuclear modification factor $R_{AA}$ is performed as a function of transverse momentum $p_T$ in several centrality classes at forward rapidity (2.5 < y < 4) and midrapidity (|y| < 0.8) for muons and electrons from heavy-flavour hadron decays, respectively. A suppression by a factor up to about 2.5 compared to the binary-scaled pp reference is observed in central collisions at both central and forward rapidities. The $R_{AA}$ of muons from heavy-flavour hadron decays is compared to previous measurements in Pb–Pb collisions at $\sqrt{s_{\rm NN}}$ = 5.02 TeV. When the nuclear modification factors are compared in the centrality classes 0–10% for Xe–Xe collisions and 10–20% for Pb–Pb collisions, which have similar charged-particle multiplicity density, a similar suppression, with $R_{AA}$ ∼ 0.4 in the $p_T$ interval 4 < $p_T$ < 8 GeV/c, is observed. The comparison of the measured $R_{AA}$ values in the two collision systems brings new insights on the properties of the quark-gluon plasma by investigating the system-size and geometry dependence of medium-induced parton energy loss. The results of muons and electrons from heavy-flavour hadron decays provide new constraints to model calculations