V-slotted screw head and matching driving tool facilitate insertion and removal of screw fasteners

A V-slotted designed screw and a screwdriver with a V-shaped tang facilitate driving the screw into difficult locations and minimize axial forces thus avoiding damage to the screw

Better but still biased: Analytic cognitive style and belief bias

Belief bias is the tendency for prior beliefs to influence people's deductive reasoning in two ways: through the application of a simple belief-heuristic (response bias) and through the application of more effortful reasoning for unbelievable conclusions (accuracy effect or motivated reasoning). Previous research indicates that cognitive ability is the primary determinant of the effect of beliefs on accuracy. In the current study, we show that the mere tendency to engage analytic reasoning (analytic cognitive style) is responsible for the effect of cognitive ability on motivated reasoning. The implications of this finding for our understanding of the impact of individual differences on belief bias are discussed

Performance of Small-Fruited Pumpkin Cultivars in Maine

A small-fruited (2-4 lb) or “pie” type pumpkin variety trial was established in the spring of 2009 at Highmoor Farm in Monmouth, ME. Three replications of seven varieties were direct-seeded on 18 June through black plastic mulch. Plots were 18 feet long with three feet between plants and six feet between rows. All fertilizer was applied according to soil test recommendations and incorporated prior to mulch application and seeding. Fruit were harvested on 18 September. Top performing varieties in terms of yield per plot included ‘Chucky’, ‘Small Sugar’, and ‘Field Trip’. ‘Fall Splendor’ produced the largest fruit in the trial, followed by ‘Winter Luxury’ and ‘Mystic Plus’. ‘Field Trip’ and ‘Fall Splendor’ had the highest stem quality in the trial and ‘Field Trip’, ‘Mystic Plus’ and ‘Fall Splendor’ were rated highest for exterior color and ribbing. The results of this trial suggest that ‘Field Trip’, ‘Mystic Plus’ and ‘Fall Splendor’ offer very high quality fruit with acceptable yields for pie-type pumpkins, while ‘Chucky’ offers acceptable fruit quality and very high yields.https://digitalcommons.library.umaine.edu/extension_ag/1000/thumbnail.jp

Multiple epitopes of the human ovarian cancer antigen 14C1 recognised by human IgG antibodies: their potential in immunotherapy.

We have defined a novel ovarian cancer-associated membrane antigen, 14C1, using human monoclonal antibodies derived by EBV-transformation of in situ sensitised patients' B-cells. The pattern of recognition of this antigen by these antibodies suggests that at least three epitopes are discernable. These antibodies can be used to promote the in vitro killing of ovarian cancer cells by activated macrophages and cytokines, implying a role for this antigen in the immunotherapy of ovarian malignancies. Evidence is presented that the 14C1 antigen may have some transmembrane signalling function

Where Are the People? The Human Viewpoint Approach for Architecting and Acquisition

The U.S. Department of Defense Architecture Framework (DoDAF) provides a standard framework for transforming systems concepts into a consistent set of products containing the elements and relationships required to represent a complex operational system. However, without a human perspective, the current DoDAF does not account for the human performance aspects needed to calculate the human contribution to system effectiveness and cost. The Human Viewpoint gives systems engineers additional tools to integrate human considerations into systems development by facilitating identification and collection of human-focused data. It provides a way to include Human Systems Integration (HSI) constructs into mainstream acquisition and systems engineering processes by promoting early, frequent coordination of analysis efforts by both the systems engineering and HSI communities

An Examination of Cesarean and Vaginal Birth Histories Among Hispanic Women Entering Prenatal Care in Two California Counties with Large Immigrant Populations

Repeat cesarean delivery (CD) rates among US Hispanic women are the highest of all racial/ethnic groups (90%). Vaginal birth after cesarean (VBAC) is an alternative delivery method, but requires medical records documentation of a non-vertical incision and favorable conditions in the current pregnancy. VBAC rates for Hispanic women are extremely low. This study explores the birth histories and medical records access among Hispanic women in California, taking into account the potential role of immigration on access to VBAC. Study aims are to describe for a sample of Hispanic women: (1) CD and VBAC histories as well as history of vaginal delivery preceding CD; and (2) medical records access, among women who had previous births in Mexico. Chart review was conducted for prenatal patients from three safety net clinics in two California counties with large Mexican migrant populations between August, 2003 and February 2004—during which VBAC was widely available in these two counties to determine: obstetric histories, CD details, birthplace and whether or not medical records had been requested/obtained for CD. 355 multiparous Hispanic women were included. Thirty-three percent had a previous CD, almost two-thirds (64%) had only one CD. Over half of the women (55%) with 2+ births and CD history also reported a vaginal birth history. Medical records for CD were infrequently requested (29%). Of those requested, records were received for 77% of women with a US CD, compared with 13% of women with Mexican CD histories. Policies to address: (1) VBAC opportunities for low risk women, such as those with prior vaginal births and one CD, and (2) overcoming limited medical records access, could mitigate against unnecessary CD and associated medical expenditures and risks for future complications

The Digital Sky Project: Prototyping Virtual Observatory Technologies

Astronomy is entering a new era as multiple, large area, digital sky surveys are in production. The resulting datasets are truly remarkable in their own right; however, a revolutionary step arises in the aggregation of complimentary multi-wavelength surveys (i.e., the cross-identification of a billion sources). The federation of these large datasets is already underway, and is producing a major paradigm shift as Astronomy has suddenly become an immensely data-rich field. This new paradigm will enable quantitatively and qualitatively new science, from statistical studies of our Galaxy and the large-scale structure in the universe, to discoveries of rare, unusual, or even completely new types of astronomical objects and phenomena. Federating and then exploring these large datasets, however, is an extremely challenging task. The Digital Sky project was initiated with this task in mind and is working to develop the techniques and technologies necessary to solve the problems inherent in federating these large databases, as well as the mining of the resultant aggregate data.Comment: 8 pages, 3 Figures, uses newpasp.sty (included). To be published in the proceedings of the conference "Virtual Observatories of the Future," editors R.J. Brunner, S.G. Djorgovski, and Alex S. Szala

Structural and Regulatory Characterization of the Placental Epigenome at Its Maternal Interface

Epigenetics can be loosely defined as the study of cellular “traits” that influence biological phenotype in a fashion that is not dependent on the underlying primary DNA sequence. One setting in which epigenetics is likely to have a profound influence on biological phenotype is during intrauterine development. In this context there is a defined and critical window during which balanced homeostasis is essential for normal fetal growth and development. We have carried out a detailed structural and functional analysis of the placental epigenome at its maternal interface. Specifically, we performed genome wide analysis of DNA methylation in samples of chorionic villus (CVS) and maternal blood cells (MBC) using both commercially available and custom designed microarrays. We then compared these data with genome wide transcription data for the same tissues. In addition to the discovery that CVS genomes are significantly more hypomethylated than their MBC counterparts, we identified numerous tissue-specific differentially methylated regions (T-DMRs). We further discovered that these T-DMRs are clustered spatially along the genome and are enriched for genes with tissue-specific biological functions. We identified unique patterns of DNA methylation associated with distinct genomic structures such as gene bodies, promoters and CpG islands and identified both direct and inverse relationships between DNA methylation levels and gene expression levels in gene bodies and promoters respectively. Furthermore, we found that these relationships were significantly associated with CpG content. We conclude that the early gestational placental DNA methylome is highly organized and is significantly and globally associated with transcription. These data provide a unique insight into the structural and regulatory characteristics of the placental epigenome at its maternal interface and will drive future analyses of the role of placental dysfunction in gestational disease

Design of the Spitzer Space Telescope Heritage Archive

It is predicted that Spitzer Space Telescope’s cryogen will run out in April 2009, and the final reprocessing for the cryogenic mission is scheduled to end in April 2011, at which time the Spitzer archive will be transferred to the NASA/IPAC Infrared Science Archive (IRSA) for long-term curation. The Spitzer Science Center (SSC) and IRSA are collaborating to design and deploy the Spitzer Heritage Archive (SHA), which will supersede the current Spitzer archive. It will initially contain the raw and final reprocessed cryogenic science products, and will eventually incorporate the final products from the Warm mission. The SHA will be accompanied by tools deemed necessary to extract the full science content of the archive and by comprehensive documentation