2,131 research outputs found
On the combination of omics data for prediction of binary outcomes
Enrichment of predictive models with new biomolecular markers is an important
task in high-dimensional omic applications. Increasingly, clinical studies
include several sets of such omics markers available for each patient,
measuring different levels of biological variation. As a result, one of the
main challenges in predictive research is the integration of different sources
of omic biomarkers for the prediction of health traits. We review several
approaches for the combination of omic markers in the context of binary outcome
prediction, all based on double cross-validation and regularized regression
models. We evaluate their performance in terms of calibration and
discrimination and we compare their performance with respect to single-omic
source predictions. We illustrate the methods through the analysis of two real
datasets. On the one hand, we consider the combination of two fractions of
proteomic mass spectrometry for the calibration of a diagnostic rule for the
detection of early-stage breast cancer. On the other hand, we consider
transcriptomics and metabolomics as predictors of obesity using data from the
Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome
(DILGOM) study, a population-based cohort, from Finland
Ranger Block III attitude control system - Manufacturing, testing, and performance
Manufacturing, test program, and performance characteristics of Range Block III attitude control syste
On Virtual Displacement and Virtual Work in Lagrangian Dynamics
The confusion and ambiguity encountered by students, in understanding virtual
displacement and virtual work, is discussed in this article. A definition of
virtual displacement is presented that allows one to express them explicitly
for holonomic (velocity independent), non-holonomic (velocity dependent),
scleronomous (time independent) and rheonomous (time dependent) constraints. It
is observed that for holonomic, scleronomous constraints, the virtual
displacements are the displacements allowed by the constraints. However, this
is not so for a general class of constraints. For simple physical systems, it
is shown that, the work done by the constraint forces on virtual displacements
is zero. This motivates Lagrange's extension of d'Alembert's principle to
system of particles in constrained motion. However a similar zero work
principle does not hold for the allowed displacements. It is also demonstrated
that d'Alembert's principle of zero virtual work is necessary for the
solvability of a constrained mechanical problem. We identify this special class
of constraints, physically realized and solvable, as {\it the ideal
constraints}. The concept of virtual displacement and the principle of zero
virtual work by constraint forces are central to both Lagrange's method of
undetermined multipliers, and Lagrange's equations in generalized coordinates.Comment: 12 pages, 10 figures. This article is based on an earlier article
physics/0410123. It includes new figures, equations and logical conten
Automatic Filters for the Detection of Coherent Structure in Spatiotemporal Systems
Most current methods for identifying coherent structures in
spatially-extended systems rely on prior information about the form which those
structures take. Here we present two new approaches to automatically filter the
changing configurations of spatial dynamical systems and extract coherent
structures. One, local sensitivity filtering, is a modification of the local
Lyapunov exponent approach suitable to cellular automata and other discrete
spatial systems. The other, local statistical complexity filtering, calculates
the amount of information needed for optimal prediction of the system's
behavior in the vicinity of a given point. By examining the changing
spatiotemporal distributions of these quantities, we can find the coherent
structures in a variety of pattern-forming cellular automata, without needing
to guess or postulate the form of that structure. We apply both filters to
elementary and cyclical cellular automata (ECA and CCA) and find that they
readily identify particles, domains and other more complicated structures. We
compare the results from ECA with earlier ones based upon the theory of formal
languages, and the results from CCA with a more traditional approach based on
an order parameter and free energy. While sensitivity and statistical
complexity are equally adept at uncovering structure, they are based on
different system properties (dynamical and probabilistic, respectively), and
provide complementary information.Comment: 16 pages, 21 figures. Figures considerably compressed to fit arxiv
requirements; write first author for higher-resolution version
Nonlinear magnetoinductive transmission lines
Power transmission in one-dimensional nonlinear magnetic metamaterials driven
at one end is investigated numerically and analytically in a wide frequency
range. The nonlinear magnetic metamaterials are composed of varactor-loaded
split-ring resonators which are coupled magnetically through their mutual
inductances, forming thus a magnetoiductive transmission line. In the linear
limit, significant power transmission along the array only appears for
frequencies inside the linear magnetoinductive wave band. We present
analytical, closed form solutions for the magnetoinductive waves transmitting
the power in this regime, and their discrete frequency dispersion. When
nonlinearity is important, more frequency bands with significant power
transmission along the array may appear. In the equivalent circuit picture, the
nonlinear magnetoiductive transmission line driven at one end by a relatively
weak electromotive force, can be modeled by coupled
resistive-inductive-capacitive (RLC) circuits with voltage-dependent
capacitance. Extended numerical simulations reveal that power transmission
along the array is also possible in other than the linear frequency bands,
which are located close to the nonlinear resonances of a single nonlinear RLC
circuit. Moreover, the effectiveness of power transmission for driving
frequencies in the nonlinear bands is comparable to that in the linear band.
Power transmission in the nonlinear bands occurs through the linear modes of
the system, and it is closely related to the instability of a mode that is
localized at the driven site.Comment: 11 pages, 11 figures, submitted to International Journal of
Bifurcation and Chao
All Doors Lead to the Kitchen â Sustainability and Wellbeing Challenges in a Shared Centrepiece of Living
The kitchen figures a central place in the home where a significant share of a householdâs resource consumption takes place. Sharing the kitchen between multiple households has potential to bring positive sustainability effects due to more efficient use of both material resources and energy. The concept of shared kitchens has, however, thus far had a limited diffusion. This paper explores the potential of shared kitchens as a future sustainable living environment by studying user experiences from a Living Lab setting. It builds the base for an overarching larger European collaboration on how future shared kitchens should be designed in order to support everyday practices while optimising the conditions for achieving positive impact on both sustainability and wellbeing. Findings are presented from five focus areas concerning different use contexts: (1) accessing, (2) cooking, (3) living and socialising, (4) storing, and (5) cleaning
Leaching behaviour of cementitious nuclear wasteforms containing caesium and strontium
The leaching behaviour and physicochemical properties of cementitious nuclear wasteforms containing caesium and strontium waste simulants has been investigated. The cement wasteform consisted of a 9â¶1 blend of blast furnace slag and ordinary Portland cement. Both non-loaded samples and samples that were waste loaded with 3 wt-% caesium and strontium added as nitrates have been studied. The cement hydration phases in the samples were identified, and the porosity and microstructure were analysed before leaching. The samples were leached for up to 6 months and the leached elements quantified. In the waste loaded cements, portlandite was not formed, and the monosulphate AFm phase appeared to be altered by the incorporation of the Sr(NO3)2. Incorporation of Cs and Sr also resulted in the increase in the leach rate of Ca2+
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