Assessment of Financial Risk Prediction Models with Multi-criteria Decision Making Methods

A wide range of classification models have been explored for financial risk prediction, but conclusions on which technique behaves better may vary when different performance evaluation measures are employed. Accordingly, this paper proposes the use of multiple criteria decision making tools in order to give a ranking of algorithms. More specifically, the selection of the most appropriate credit risk prediction method is here modeled as a multi-criteria decision making problem that involves a number of performance measures (criteria) and classification techniques (alternatives). An empirical study is carried out to evaluate the performance of ten algorithms over six real-life credit risk data sets. The results reveal that the use of a unique performance measure may lead to unreliable conclusions, whereas this situation can be overcome by the application of multi-criteria decision making techniques

Effects of Diabetes and Insulin on α-amylase Messenger RNA Levels in Rat Parotid Glands

Previous studies have shown that amylase levels are reduced significantly in the pancreas and parotid gland of diabetic rats and that insulin reverses this effect and increases the secretory protein levels. In the pancreas, these changes in amylase protein levels are accompanied by parallel changes in amylase mRNA levels. In the present study, the effects of diabetes and subsequent insulin treatments on contents (per cell) of amylase protein and its mRNA in parotid glands were compared in rats rendered diabetic with an injection of a beta-cell toxin, streptozotocin (STZ). Both amylase protein and its mRNA contents were reduced significantly in diabetic rats, compared with control rats, and this reduction was reversed following insulin injections of diabetic rats. In insulin-injected diabetic rats, amylase protein contents increased before a detectable increase in amylase mRNA levels was seen. The mRNA contents of a non-secretory protein, actin, did not change during diabetogenesis or subsequent insulin treatments. The reductions in parotid contents of amylase and its mRNA in diabetic rats and the reversal of these changes by insulin are similar to those changes that occur in the pancreas under the same conditions. However, the magnitude of these changes in parotid glands was much smaller than in the pancreas, and the effect of insulin on amylase mRNA synthesis was not as immediate as in the latter gland.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67977/2/10.1177_00220345900690081001.pd

Management of upper limb disorders and the biopsychosocial model

This review, using a best evidence synthesis, examined the evidence on management strategies for work-relevant upper limb disorders and established the extent to which the biopsychosocial model can be applied. Articles were found through systematic searching of electronic databases together with citation tracking. Information from included articles was extracted into evidence tables. Themes were identified and the information synthesised into high level evidence statements, which were distilled into key messages. The main results are presented in thematic sections covering classification/diagnosis, epidemiology, associations/risks, and management/treatment, focusing on return to work and taking account of distinctions between non-specific complaints and specific diagnoses. Neither medical treatment nor ergonomic workplace interventions alone offer an optimal solution; rather, multimodal interventions show considerable promise, particularly for vocational outcomes. Early return to work, or work retention, is an important goal for most cases and may be facilitated, where necessary, by transitional work arrangements. The emergent evidence indicates that successful management strategies require all the players to be onside and acting in a coordinated fashion; this requires engaging employers and workers to participate. The biopsychosocial model applies: biological considerations should not be ignored, but it is psychosocial factors that are important for vocational and disability outcomes. Implementation of interventions that address the full range of psychosocial issues will require a cultural shift in the way the relationship between upper limb complaints and work is conceived and handled. A number of evidence-based messages emerged, which can contribute to the needed cultural shift

The biology of coral metamorphosis: Molecular responses of larvae to inducers of settlement and metamorphosis

Like many other cnidarians, corals undergo metamorphosis from a motile planula larva to a sedentary polyp. In some sea anemones such as Nematostella this process is a smooth transition requiring no extrinsic stimuli, but in many corals it is more complex and is cue-driven. To better understand the molecular events underlying coral metamorphosis, competent larvae were treated with either a natural inducer of settlement (crustose coralline algae chips/extract) or LWamide, which bypasses the settlement phase and drives larvae directly into metamorphosis. Microarrays featuring >8000 Acropora unigenes were used to follow gene expression changes during the 12h period after these treatments, and the expression patterns of specific genes, selected on the basis of the array experiments, were investigated by in situ hybridization. Three patterns of expression were common-an aboral pattern restricted to the searching/settlement phase, a second phase of aboral expression corresponding to the beginning of the development of the calicoblastic ectoderm and continuing after metamorphosis, and a later orally-restricted pattern.L.C. Grasso, A.P. Negri, S. Fôret, R. Saint, D.C. Hayward, D.J. Miller, E.E. Bal