649 research outputs found
Tank Battle And Trivia Quiz Games Development Using Construct 2 To Improve Critical Thinking Ability
Game is something that is fun and
entertaining 'of all time' and will always be in
this world and can be enjoyed by both
children, and adults. There are various types
of games that are often played, including
shooting and quiz games. Shooting Game has
the main theme of shooting where players will
beat each other to become the winner. While
Quiz Game or often called Trivia Quiz is a
game where players try to answer the
questions given to get various kinds of prizes
and become a winner. Construct 2 is a
program for making games without writing
programming code, because most of the
game's logic can be arranged via the menu.
This study aims to create a game design
that is a combination of Shooting Game and
Trivia Quiz where players can play both types
of games simultaneously. While the program
used is construct 2. And the sample used is 16
years and over. The methodology used is
object-oriented design methodology. The
modeling tools used are use case diagrams,
activity diagrams and class diagrams. The
results of making this game show that
combining more than one type of game can be
done and make a game more interesting
Coherent magnetic semiconductor nanodot arrays
In searching appropriate candidates of magnetic semiconductors compatible with mainstream Si technology for future spintronic devices, extensive attention has been focused on Mn-doped Ge magnetic semiconductors. Up to now, lack of reliable methods to obtain high-quality MnGe nanostructures with a desired shape and a good controllability has been a barrier to make these materials practically applicable for spintronic devices. Here, we report, for the first time, an innovative growth approach to produce self-assembled and coherent magnetic MnGe nanodot arrays with an excellent reproducibility. Magnetotransport experiments reveal that the nanodot arrays possess giant magneto-resistance associated with geometrical effects. The discovery of the MnGe nanodot arrays paves the way towards next-generation high-density magnetic memories and spintronic devices with low-power dissipation
Molecular Analysis of Precursor Lesions in Familial Pancreatic Cancer
PMCID: PMC3553106This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Laparoscopic Sleeve Gastrectomy is a Safe and Effective Bariatric Procedure for the Lower BMI (35.0–43.0 kg/m2) Population
# The Author(s) 2010. This article is published with open access at Springerlink.com Background The laparoscopic vertical sleeve gastrectomy (LSG) is derived from the biliopancreatic diversion with duodenal switch operation (Marceau et al., Obes Surg 3:29
Difference-based clustering of short time-course microarray data with replicates
<p>Abstract</p> <p>Background</p> <p>There are some limitations associated with conventional clustering methods for short time-course gene expression data. The current algorithms require prior domain knowledge and do not incorporate information from replicates. Moreover, the results are not always easy to interpret biologically.</p> <p>Results</p> <p>We propose a novel algorithm for identifying a subset of genes sharing a significant temporal expression pattern when replicates are used. Our algorithm requires no prior knowledge, instead relying on an observed statistic which is based on the first and second order differences between adjacent time-points. Here, a pattern is predefined as the sequence of symbols indicating direction and the rate of change between time-points, and each gene is assigned to a cluster whose members share a similar pattern. We evaluated the performance of our algorithm to those of K-means, Self-Organizing Map and the Short Time-series Expression Miner methods.</p> <p>Conclusions</p> <p>Assessments using simulated and real data show that our method outperformed aforementioned algorithms. Our approach is an appropriate solution for clustering short time-course microarray data with replicates.</p
Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine
published_or_final_versio
Expression, purification, and characterization of a novel Ca2+- and phospholipid-binding protein annexin B2
Annexin B2 (AnxB2) is a novel member of the annexin family of Ca2+- and phospholipid-binding proteins from Cysticercus cellulosae. To obtain highly pure AnxB2 with an easy and inexpensive purification approach, its cDNA was cloned into the prokaryotic expression vector pJLA503 and the translation initiation codon was immediately under the control of the inducible bacteriophage λ promoters PR and PL. After induction by shifting temperature, large amounts of non-fusion protein were produced in Escherichia coli in a soluble form. Then a novel purification method based on Ca2+-dependent phosphatidylserine (PS)-binding activity was established, whereby the purity of AnxB2 was increased to 98.7%. Western blot analysis showed that recombinant AnxB2 was specifically recognized by serum of pigs infected with cysticercosis. In vitro test showed that, the recombinant AnxB2 had anticoagulant activity and platelet binding activity. The expression, purification, and initial characterization of AnxB2 set an important stage for further characterization of the protein
Cork oak vulnerability to fire: the role of bark harvesting, tree characteristics and abiotic factors
Forest ecosystems where periodical tree bark harvesting is a major economic activity may be particularly vulnerable to
disturbances such as fire, since debarking usually reduces tree vigour and protection against external agents. In this paper
we asked how cork oak Quercus suber trees respond after wildfires and, in particular, how bark harvesting affects post-fire
tree survival and resprouting. We gathered data from 22 wildfires (4585 trees) that occurred in three southern European
countries (Portugal, Spain and France), covering a wide range of conditions characteristic of Q. suber ecosystems. Post-fire
tree responses (tree mortality, stem mortality and crown resprouting) were examined in relation to management and
ecological factors using generalized linear mixed-effects models. Results showed that bark thickness and bark harvesting are
major factors affecting resistance of Q. suber to fire. Fire vulnerability was higher for trees with thin bark (young or recently
debarked individuals) and decreased with increasing bark thickness until cork was 3–4 cm thick. This bark thickness
corresponds to the moment when exploited trees are debarked again, meaning that exploited trees are vulnerable to fire
during a longer period. Exploited trees were also more likely to be top-killed than unexploited trees, even for the same bark
thickness. Additionally, vulnerability to fire increased with burn severity and with tree diameter, and was higher in trees
burned in early summer or located in drier south-facing aspects. We provided tree response models useful to help
estimating the impact of fire and to support management decisions. The results suggested that an appropriate
management of surface fuels and changes in the bark harvesting regime (e.g. debarking coexisting trees in different years or
increasing the harvesting cycle) would decrease vulnerability to fire and contribute to the conservation of cork oak
ecosystemsinfo:eu-repo/semantics/publishedVersio
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