A single-case series investigation of the efficacy of an internet delivered multi-session cognitive bias modification – interpretation task in a population with clinical levels of panic symptomatology.

Cognitive bias modification for interpretation bias (CBM-I) has been shown to successfully modify interpretative biases across psychological presentations including social anxiety, generalised anxiety and depression. Despite the role catastrophic misinterpretations of bodily sensations are thought to maintain with panic disorder, to date no study has sought to explore the efficacy of CBM-I with individuals with clinical levels of panic symptomatology. Six individuals (19 to 53 years old) with clinical levels of panic symptomatology, as measured by the panic disorder severity scale, completed an internet administered seven session CBM-I training programme at home. A single-case series design was adopted in order to investigate the efficacy of the CBM-I training programme. Participants were randomised to a seven, nine or eleven day baseline control phase. Daily measures and outcome measures were completed. Visual analysis revealed that four of the six participants responded to the CBM-I training programme. Three participants made clinically significant and reliable change on a measure of panic, whilst four participants made significantly reliable change on a measure of anxiety sensitivity. Interpretation bias was assessed using the ranking and believability tasks of the Brief Body Sensations Interpretation Questionnaire. Four of the six participants showed a significant change in interpretation bias on the ranking task, whilst only two participants showed a change in interpretation bias in the expected direction on the believability task. The results indicate the potential clinical utility of CBM-I in reducing levels of panic symptomatology. These results need to be interpreted with caution due to the small sample size. Future areas for research are considered, with the potential for CBM-I to serve a preventative, as well as a therapeutic, function discussed

Public opinion and understanding of the impact of electric vehicles:a UK experience

The UK Government places pressure on the automotive industry to reduce carbon emissions by prioritising the manufacture of alternative fuel vehicles. Hence, electric vehicles (EVs) are a priority for the automotive industry given they emit minimal carbon emissions compared to petrol and diesel vehicles. Despite the continued improvement in the manufacture of EVs, issues regarding the viability and affordability of the vehicles influence the market for EVs. This paper explores opinions regarding (i) the viability and environmental impact of EVs as a replacement for petrol/diesel vehicles; (ii) the affordability of EVs; and (iii) knowledge and familiarity of the use of EVs. 130 respondents to a questionnaire, along with interviews with participants within the automotive industry inlcuding an owner of an EV, generally supported literature on the study of EVs. Findings of this research identified that views relating to the viability of EVs focussed on range anxiety, charging speeds and battery life. Views relating to the affordability of EVs are influenced by the initial purchase price of the vehicle, along with costs associated with the battery and charging point. Finally, it is clear that consumers with greater knowledge about EV technologies are more likely to embrace EVs

Assessing whether environmental impact is a criterion of consumers when selecting an airline

The aim of this study is to gain insight as to whether environmental impact is a criterion of consumers when actually selecting an airline. Findings indicate that cost and convenience, followed by destinations on offer and departure airports, are the key criteria for consumers in airline ticket purchasing decisions. Airlines may continue environmental activity and disclosure for long-term strategic reasons although individual ticket purchase decisions do not appear to be based primarily on environmental considerations. The research fills a gap in the U.K. empirical literature by exploring whether consumers of airlines operating out of the U.K. consider environmental impacts when making actual ticket purchase decisions

Assurance Methods for designing a clinical trial with a delayed treatment effect

An assurance calculation is a Bayesian alternative to a power calculation. One may be performed to aid the planning of a clinical trial, specifically setting the sample size or to support decisions about whether or not to perform a study. Immuno-oncology (IO) is a rapidly evolving area in the development of anticancer drugs. A common phenomenon that arises from IO trials is one of delayed treatment effects, that is, there is a delay in the separation of the survival curves. To calculate assurance for a trial in which a delayed treatment effect is likely to be present, uncertainty about key parameters needs to be considered. If uncertainty is not considered, then the number of patients recruited may not be enough to ensure we have adequate statistical power to detect a clinically relevant treatment effect. We present a new elicitation technique for when a delayed treatment effect is likely to be present and show how to compute assurance using these elicited prior distributions. We provide an example to illustrate how this could be used in practice. Open-source software is provided for implementing our methods. Our methodology makes the benefits of assurance methods available for the planning of IO trials (and others where a delayed treatment expect is likely to occur)

The demography of free-roaming dog populations and applications to disease and population control

Understanding the demography of domestic dog populations is essential for effective disease control, particularly of canine-mediated rabies. Demographic data are also needed to plan effective population management. However, no study has comprehensively evaluated the contribution of demographic processes (i.e. births, deaths and movement) to variations in dog population size or density, or determined the factors that regulate these processes, including human factors. We report the results of a 3-year cohort study of domestic dogs, which is the first to generate detailed data on the temporal variation of these demographic characteristics. The study was undertaken in two communities in each of Bali, Indonesia and Johannesburg, South Africa, in rabies-endemic areas and where the majority of dogs were free-roaming. None of the four communities had been engaged in any dog population management interventions by local authorities or animal welfare organizations. All identified dogs in the four communities were monitored individually throughout the study. We observed either no population growth or a progressive decline in population size during the study period. There was no clear evidence that population size was regulated through environmental resource constraints. Rather, almost all of the identified dogs were owned and fed regularly by their owners, consistent with population size regulated by human demand. Finally, a substantial fraction of the dogs originated from outside the population, entirely through the translocation of dogs by people, rather than from local births. These findings demonstrate that previously reported growth of dog populations is not a general phenomenon and challenge the widely held view that free-roaming dogs are unowned and form closed populations. Synthesis and applications. These observations have broad implications for disease and population control. The accessibility of dogs for vaccination and evaluation through owners and the movement of dogs (some of them infected) by people will determine the viable options for disease control strategies. The impact of human factors on population dynamics will also influence the feasibility of annual vaccination campaigns to control rabies and population control through culling or sterilization. The complex relationship between dogs and people is critically important in the transmission and control of canine-mediated rabies. For effective management, human factors must be considered in the development of disease and population control programmes

High resolution imaging of the M​L​ 2.9 August 2019 earthquake in Lancashire, UK, induced by hydraulic fracturing during Preston New Road PNR-2 operations

Hydraulic fracturing (HF) at Preston New Road (PNR), Lancashire, United Kingdom, in August 2019, induced a number of felt earthquakes. The largest event (⁠ML 2.9) occurred on 26 August 2019, approximately three days after HF operations at the site had stopped. Following this, in November 2019, the United Kingdom Government announced a moratorium on HF for shale gas in England. Here we provide an analysis of the microseismic observations made during this case of HF‐induced fault activation. More than 55,000 microseismic events were detected during operations using a downhole array, the vast majority measuring less than Mw 0. Event locations revealed the growth of hydraulic fractures and their interaction with several preexisting structures. The spatiotemporal distribution of events suggests that a hydraulic pathway was created between the injection points and a nearby northwest–southeast‐striking fault, on which the largest events occurred. The aftershocks of the ML 2.9 event clearly delineate the rupture plane, with their spatial distribution forming a halo of activity around the mainshock rupture area. Across clusters of events, the magnitude distributions are distinctly bimodal, with a lower Gutenberg–Richter b‐value for events above Mw 0, suggesting a break in scaling between events associated with hydraulic fracture propagation, and events associated with activation of the fault. This poses a challenge for mitigation strategies that rely on extrapolating microseismicity observed during injection to forecast future behavior. The activated fault was well oriented for failure in the regional stress field, significantly more so than the fault activated during previous operations at PNR in 2018. The differing orientations within the stress field likely explain why this PNR‐2 fault produced larger events compared with the 2018 sequence, despite receiving a smaller volume of injected fluid. This indicates that fault orientation and in situ stress conditions play a key role in controlling the severity of seismicity induced by HF

Communications policy meeting report : IITA Dar es Salaam

The objectives of the meeting were to identify communications policy issues that affect farmers’ access to information on agricultural technologies and propose ways to address challenges in Tanzania. The meetings covered topics of: agricultural extension; policy and how it affects farmers; timely dissemination of agricultural information; and, communication channels. The report includes a record of participation and the workshop agenda

Summary of findings from the SILT project outcome evaluation survey on common beans in northern regions of Tanzania

An important component of the Scaling Up Improved Legume Technologies (SILT) project was implementation (by Farm Radio International and partners) of radio programs on improved practices for common beans, aired in the northern Regions of Tanzania: Arusha and Manyara. This evaluation assesses the reach and impact of interactive rural radio programs on farmers’ knowledge and up-take of improved common bean technologies promoted by the SILT project; and assesses potential synergies between multiple SILT extension activities: Radio, Demonstration plots, Leaflets, and a campaign around Shujaaz comics

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates

The deleterious effects of prolonged sleep deprivation on behavior and cognition are a concern in modern society. Persons at risk for impaired performance and health-related issues resulting from prolonged sleep loss would benefit from agents capable of reducing these detrimental effects at the time they are sleep deprived. Agents capable of improving cognition by enhancing brain activity under normal circumstances may also have the potential to reduce the harmful or unwanted effects of sleep deprivation. The significant prevalence of excitatory α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamatergic receptors in the brain provides a basis for implementing a class of drugs that could act to alter or remove the effects of sleep deprivation. The ampakine CX717 (Cortex Pharmaceuticals), a positive allosteric modulator of AMPA receptors, was tested for its ability to enhance performance of a cognitive, delayed match-to-sample task under normal circumstances in well-trained monkeys, as well as alleviate the detrimental effects of 30–36 h of sleep deprivation. CX717 produced a dose-dependent enhancement of task performance under normal alert testing conditions. Concomitant measures of regional cerebral metabolic rates for glucose (CMR(glc)) during the task, utilizing positron emission tomography, revealed increased activity in prefrontal cortex, dorsal striatum, and medial temporal lobe (including hippocampus) that was significantly enhanced over normal alert conditions following administration of CX717. A single night of sleep deprivation produced severe impairments in performance in the same monkeys, accompanied by significant alterations in task-related CMR(glc) in these same brain regions. However, CX717 administered to sleep-deprived monkeys produced a striking removal of the behavioral impairment and returned performance to above-normal levels even though animals were sleep deprived. Consistent with this recovery, CMR(glc) in all but one brain region affected by sleep deprivation was also returned to the normal alert pattern by the drug. The ampakine CX717, in addition to enhancing cognitive performance under normal alert conditions, also proved effective in alleviating impairment of performance due to sleep deprivation. Therefore, the ability to activate specific brain regions under normal alert conditions and alter the deleterious effects of sleep deprivation on activity in those same regions indicate a potential role for ampakines in sustaining performance under these types of adverse conditions