Resolution of Diplopia after thirty three years

A 54-year-old male sustained a fractured right orbital floor 33 years ago, which was treated with a silastic implant. His diplopia never resolved, and he presented to us with an acute orbital cellulitis. Computerized tomography showed a displaced inferior rectus and entrapment of both inferior and medial recti. The implant was removed surgically via a Caldwell– Luc approach and his diplopia completely resolved after 33 years

Challenging the teaching of geographies of exclusion – the potential of geocapabilities for a transcultural approach in Australian and English schools

This expository paper critically examines the value of school geography in social debates that have a direct significance for the lives of young people. Migration is chosen as a focus, both because it is a defining feature of everyday life and the world we live in, and an area of research and debate in the discipline of geography. We draw on two national contexts, those of Australia and England, and illustrative examples from the authors’ research, to discuss how social change through migration is explored, expressed and represented in geography education by the national curriculum of each country. This occurs through two particular lenses, geocapabilities and transculturalism, which are presented as potential transformative strategies for ensuring that geographical teaching of such issues remains pertinent to the lives and futures of the young people in the classroom. In doing so, the paper seeks to critically consider the omnipresent socio-political agendas and landscapes of compulsory schooling in each nation that influence the construction of geography education, using the context of migration as a defining social dimension of contemporary global society. The paper concludes by arguing that geography teachers and educators should actively consider the use of a geocapabilities and/or transcultural lens when exploring complex social geographies such as migration. In doing so, it is contended that these dual concepts can support and empower young people in their academic and social navigation of the complexities of current society

Distance Metric Learning using Graph Convolutional Networks: Application to Functional Brain Networks

Evaluating similarity between graphs is of major importance in several computer vision and pattern recognition problems, where graph representations are often used to model objects or interactions between elements. The choice of a distance or similarity metric is, however, not trivial and can be highly dependent on the application at hand. In this work, we propose a novel metric learning method to evaluate distance between graphs that leverages the power of convolutional neural networks, while exploiting concepts from spectral graph theory to allow these operations on irregular graphs. We demonstrate the potential of our method in the field of connectomics, where neuronal pathways or functional connections between brain regions are commonly modelled as graphs. In this problem, the definition of an appropriate graph similarity function is critical to unveil patterns of disruptions associated with certain brain disorders. Experimental results on the ABIDE dataset show that our method can learn a graph similarity metric tailored for a clinical application, improving the performance of a simple k-nn classifier by 11.9% compared to a traditional distance metric.Comment: International Conference on Medical Image Computing and Computer-Assisted Interventions (MICCAI) 201

The Cell Cycle Regulator Protein 14-3-3 sigma Is Essential for Hair Follicle Integrity and Epidermal Homeostasis

The 14-3-3σ (Stratifin; Sfn) is a cell cycle regulator intimately involved in the program of epithelial keratinization. 14-3-3σ is unique in that it is expressed primarily in epithelial cells and is frequently silenced in epithelial cancers. Despite its well-documented role as a cell cycle regulator and as a tumor suppressor, the function of 14-3-3σ in the intricate balance of proliferation and differentiation in epithelial development is poorly understood. A mutation in 14-3-3σ was found to be responsible for the repeated epilation (Er) phenotype. It has previously been shown that Sfn+/Er mice are characterized by repeated hair loss and regrowth, whereas SfnEr/Er mice die at birth displaying severe oral fusions and limb abnormalities as a result of defects in keratinizing epithelia. Here we show that mice heterozygous for the 14-3-3σ mutation have severe defects in hair shaft differentiation, resulting in destruction of the hair shaft during morphogenesis. Furthermore, we report that the interfollicular epidermis and sebaceous glands are hyperproliferative, coincident with expanded nuclear Yap1 (Yes-associated protein 1)—a critical modulator of epidermal stem cell proliferation. We also report that hair follicle stem cells in the bulge cycle abnormally, raising important questions as to the role of 14-3-3σ in the bulge

BEC-BCS Crossover of a Trapped Two-Component Fermi Gas with Unequal Masses

We determine the energetically lowest lying states in the BEC-BCS crossover regime of s-wave interacting two-component Fermi gases under harmonic confinement by solving the many-body Schrodinger equation using two distinct approaches. Essentially exact basis set expansion techniques are applied to determine the energy spectrum of systems with N=4 fermions. Fixed-node diffusion Monte Carlo methods are applied to systems with up to N=20 fermions, and a discussion of different guiding functions used in the Monte Carlo approach to impose the proper symmetry of the fermionic system is presented. The energies are calculated as a function of the s-wave scattering length a_s for N=2-20 fermions and different mass ratios \kappa of the two species. On the BEC and BCS sides, our energies agree with analytically-determined first-order correction terms. We extract the scattering length and the effective range of the dimer-dimer system up to \kappa = 20. Our energies for the strongly-interacting trapped system in the unitarity regime show no shell structure, and are well described by a simple expression, whose functional form can be derived using the local density approximation, with one or two parameters. The universal parameter \xi for the trapped system for various \kappa is determined, and comparisons with results for the homogeneous system are presented.Comment: 11 pages, 6 figures, extended versio

Effects of a torsion field on Big Bang nucleosynthesis

In this paper it is investigated whether torsion, which arises naturally in most theories of quantum gravity, has observable implications for the Big Bang nucleosynthesis. Torsion can lead to spin flips amongst neutrinos thus turning them into sterile neutrinos. In the early Universe they can alter the helium abundance which is tightly constrained by observations. Here I calculate to what extent torsion of the string theory type leads to a disagreement with the Big Bang nucleosynthesis predictions.Comment: accepted by General Relativity and Gravitatio

COVID-19 as a global challenge: towards an inclusive and sustainable future

COVID-19 is a global challenge that demands researchers, policy makers, and governments address multiple dimensions which go far beyond the implications of this pandemic for health and wellbeing. Just as the UN Sustainable Development Goals call for focus on the connections between development policy sectors, the pandemic has exposed the complex global interdependencies that underpin economies and highlighted fault lines in societal structures that perpetuate ethnic, economic, social, and gender inequalities. Here, we highlight the pandemic's emerging potential consequences for achieving sustainable development with respect to the six global challenge areas we collectively address at the UK Research and Innovation's Global Challenges Research Fund:1 food systems; education; cities and sustainable infrastructure; security, protracted conflict, refugee crises, and forced displacement; environmental resilience; and global health. As the immediate health consequences of the pandemic unfold and begin to be superseded by the impact of public health containment measures, we call for a refocusing of research and action not only to mitigate these impacts but to build sustainability and strengthened resilience into future recovery