SPEECH

Speech delivered by The Vice President of India, Shri M. Hamid Ansari on 10th January, 2016 at Vigyan Bhawan on the occasion of launching of new look of Rajya Sabha TV and inaugurating a Panel Discussion on ‘Scientific Temper: A Pre-requisite for Knowledge Based Society’

Indiai demokrácia: eredmények és kihívások

Shri M. Hamid Ansari, Indiai Köztársaság alelnöke 2016. október 15-17-ei Magyarországi látogatása során elfogadta a Budapesti Corvinus Egyetem meghívását is. Indiai demokrácia: eredmények és kihívások c. előadását telt ház előtt tartotta meg október 17-én. Az alábbiakban az előadás magyar fordítását közöljük

Psychometric Evaluation of Dietary Habits Questionnaire for Type 2 Diabetes Mellitus

This research evaluated the psychometric properties of English version of dietary habits questionnaires developed for type 2 diabetic patients. There is scarcity of literature about availability of standardized questionnaires for assessing dietary habits of type 2 diabetics in Saudi Arabia. As dietary habits vary from country to country, therefore, this was an attempt to develop questionnaires that can serve as a baseline. Through intensive literature review, four questionnaires were developed / modified and subsequently tested for psychometric properties. Prior to pilot study, a pre-test was conducted to evaluate the face validity and content validity. The pilot study was conducted from 23 October – 22 November, 2016 to evaluate the questionnaires’ reliability and validity. Systematic random sampling technique was used to collect the data from 132 patients by direct investigation method. Questionnaires assessing diabetes mellitus knowledge (0.891), dietary knowledge (0.869), dietary attitude (0.841) and dietary practices (0.874) had good internal consistency reliability. Factor analysis conducted on dietary attitude questionnaire showed a valid 5 factor solution. Directions of loadings were positive and free from factorial complexity. Relying on the data obtained from type 2 diabetics, these questionnaires can be considered as reliable and valid for the assessment of dietary habits in Saudi Arabia and neighbouring Gulf countries population

Systems Immunology Analysis Reveals an Immunomodulatory Effect of Snail-p53 Binding on Neutrophil- and T Cell-Mediated Immunity in KRAS Mutant Non-Small Cell Lung Cancer

Immunomodulation and chronic inflammation are important mechanisms utilized by cancer cells to evade the immune defense and promote tumor progression. Therefore, various efforts were focused on the development of approaches to reprogram the immune response to increase the immune detection of cancer cells and enhance patient response to various types of therapy. A number of regulatory proteins were investigated and proposed as potential targets for immunomodulatory therapeutic approaches including p53 and Snail. In this study, we investigated the immunomodulatory effect of disrupting Snail-p53 binding induced by the oncogenic KRAS to suppress p53 signaling. We analyzed the transcriptomic profile mediated by Snail-p53 binding inhibitor GN25 in non-small cell lung cancer cells (A549) using Next generation whole RNA-sequencing. Notably, we observed a significant enrichment in transcripts involved in immune response pathways especially those contributing to neutrophil (IL8) and T-cell mediated immunity (BCL6, and CD81). Moreover, transcripts associated with NF-κB signaling were also enriched which may play an important role in the immunomodulatory effect of Snail-p53 binding. Further analysis revealed that the immune expression signature of GN25 overlaps with the signature of other therapeutic compounds known to exhibit immunomodulatory effects validating the immunomodulatory potential of targeting Snail-p53 binding. The effects of GN25 on the immune response pathways suggest that targeting Snail-p53 binding might be a potentially effective therapeutic strategy

Observations on the efficiency of using different cashmere combs

The effect of using small or large cashmere combs on cashmere harvest, cashmere quality and combing time was studied on Raeini cashmere goats in nomadic goat breeding systems of the Iranian province of Kerman. Two groups of 20 goats of different ages were combed with either a large or a small comb, three times with intervals of 2 weeks in early spring when natural fiber shedding has started. Combed cashmere weight, duration of combing, fiber diameter, and down yield were measured. A sample of combed cashmere was analyzed using a Laserscan instrument. A general linear model including type of comb, stage of combing and age of goat was fitted to analyze the data. Small combs collect more cashmere (31.0 vs. 21.7 g, P 0.05) but combing time is higher (3.75 vs. 2.79 min, P < 0.01). In the first two combing sessions much more cashmere was obtained than in the last (28.1, 32.0 and 19.0 g, respectively, P < 0.01), but the weight of total combed cashmere was much less than typical shorn fleece weights. Combing can be justified only if a considerable price premium can be obtained from selling combed cashmere instead of selling shorn cashmere, or if the combed cashmere is used to add value on-farm. If this is the case, small combs with short rods are preferable since more cashmere can be collected without affecting its qualityFil: Ansari-Renani, Hamid R. Animal Science Research Institute; IránFil: Mueller, Joaquin Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Rischkowsky, Barbara. International Center for Agricultural Research in the Dry Areas; EtiopíaFil: Seyed Momend, S.M. Agriculture and Natural Resources Research Center; IránFil: Ehsani, M. Agriculture and Natural Resources Research Center; IránFil: Moradi, Sepehr. University of Zanjan. Agriculture College. Animal Science Department; Irá

Cashmere quality of Raeini goats kept by nomads in Iran

The income of the nomads in Kerman Province depends mainly on Raeini goats that produce meat, milk and cashmere. This paper assesses the cashmere quality and its variation in Raeini herds to determine the scope for improvement. In April 2010 fleece weights (FW) and midside fleece samples were taken from a total of 686 male and female cashmere goats of 1, 2 and 3 years of age belonging to 29 herds. The herds were randomly chosen in the summer grazing area of nomads within 20 km of the city of Baft, province of Kerman, South of Iran, the main cashmere producing area in Iran. Cashmere yield (CY) was determined from the weight of dehaired cashmere to weight of shorn fiber. Cashmere fibers were analyzed using an OFDA instrument. A general mixed linear model including sex, age and sex by age interaction as fixed effects and herd as random effect was used to analyze the data and measure the relationships between different cashmere characteristics and fleece attributes. The overall means ± standard deviations were for fleece weights (FW) 507 ± 183 g, cashmere yield (CY) 56.5 ± 12.2%, mean fiber diameter (MFD) 19.7 ± 1.5 μm, fiber diameter standard deviation (FDSD) 4.5 ± 0.6 μm, fiber curvature (FC) 62.9 ± 8.5°/mm and staple length (SL) 54.2 ± 7.0 mm, respectively. Herd effect was significant for all traits except for SL and sex by age effect was only significant for MFD. One year old males and females had finer cashmere than older goats. FW and FDSD were higher in males and CY and FC was higher in young animals. Pearson correlation between MFD and FC, FDSD and MFD, MFD and FW was −0.647, 0.399 and 0.211 respectively. Raeini cashmere is white, has an excellent SL and FC but is relatively coarse. Given the differences between and within herds there seems to be substantial scope to improve the commercial value of Raeini cashmere.Fil: Ansari-Renani, Hamid R. Animal Science Research Institute; IránFil: Mueller, Joaquin Pablo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Rischkowsky, Barbara. International Center for Agricultural Research in the Dry Areas; SiriaFil: Seyed Momend, S.M. Agriculture and Natural Resources Research Center; IránFil: Alipour, O. Livestock Office of Agriculture Department of Baft; IránFil: Ehsani, M. Agriculture and Natural Resources Research Center; IránFil: Moradi, Sepehr. University of Zanjan. Agriculture College. Animal Science Department; Irán. Animal Science Research Institute; Irán

Changes in the prevalence of hepatitis B and C viral infections in Sindh province, Pakistan: Findings from two sero‐surveys in 2007 and 2019

Pakistan harbours a large burden of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. We utilised repeat sero‐surveys to assess progress achieved towards hepatitis elimination in Pakistan. Multilevel logistic regression evaluated the change in HBV infection (HBV surface antigen (HBsAg)‐positive) prevalence and HCV exposure (HCV antibody (HCV‐Ab)‐positive) prevalence between two sero‐surveys from 2007 and 2019 for Sindh province and associated risk factors. Adjusted odds ratios (aORs) were estimated and population‐attributable fractions (PAF) for modifiable risk factors for HCV exposure. The 2007 and 2019 surveys included 8855 and 6672 individuals. HBsAg prevalence decreased from 2.6% (95% confidence intervals (95% CI): 2.2–2.9) in 2007 to 1.1% (95% CI: 0.8–1.3) in 2019, while HCV‐Ab prevalence increased from 5.1% (95% CI: 4.6%–5.5%) to 6.2% (95% CI: 5.6%–6.8%). The age and gender‐adjusted HBsAg prevalence decreased by 80% (aOR = 0.2, 95% CI: 0.1–0.4) among children and 60% (aOR = 0.4, 95% CI: 0.3–0.6) among adults over 2007–2019, while HCV‐Ab prevalence decreased by 60% (aOR = 0.4, 95%CI:0.2–0.7) in children and increased by 40% (aOR = 1.4, 95% CI: 1.2–1.7) in adults. HCV‐Ab prevalence was lower in adults with secondary (aOR = 0.6, 95% CI: 0.5–0.8) and higher (aOR = 0.5, 95%CI:0.3–0.8) education compared to illiterates and higher among adults reporting blood transfusion (aOR = 1.7, 95% CI: 1.2–2.4), family history of hepatitis (aOR = 2.5, 95% CI: 1.9–3.3), past year medical injection (aOR = 2.1, 95% CI: 1.6–2.7), being tattooed (aOR = 1.4, 95% CI: 1.0–1.9) and shaved by traditional barber (aOR = 1.2, 95% CI: 1.0–1.5). Modifiable risk factors accounted for 45% of HCV exposure, with medical injection(s) accounting for 38% (95%CI,25.7–48.4%). Overall HCV has increased over 2007–2019 in Sindh province, while HBV prevalence has decreased. Medical injections should be an important focus of prevention activities

Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon

The prevalence of colon-associated diseases has increased significantly over the past several decades, as evidenced by accumulated literature on conditions such as Crohn’s disease, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Developing therapeutics for these diseases is challenging due to physiological barriers of the colon, systemic side effects, and the intestinal environment. Therefore, in a search for novel methods to overcome some of these problems, researchers discovered that microbial metabolism by gut microbiotia offers a potential method for targeted drug delivery This overview highlights several drug delivery systems used to modulate the microbiota and improve colon-targeted drug delivery. This technology will be important in developing a new generation of therapies which harness the metabolism of the human gut microflora

Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity

Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/ moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target

Therapeutic Potential of Cannabinoids on Tumor Microenvironment: A Molecular Switch in Neoplasia Transformation

The efficacy of chemotherapy depends on the tumor microenvironment. This microenvironment consists of a complex cellular network that can exert both stimulatory and inhibitory effects on tumor genesis. Given the increasing interest in the effectiveness of cannabis, cannabinoids have gained much attention as a potential chemotherapy drug. Cannabinoids are a group of marker compounds found in L., more commonly known as marijuana, a psychoactive drug used since ancient times for pain management. Although the anticancer potential of , has been recognized previously, increased attention was generated after discovering the endocannabinoid system and the successful production of cannabinoid receptors. In vitro and in vivo studies on various tumor models have shown therapeutic efficiency by modifying the tumor microenvironment. However, despite extensive attention regarding potential therapeutic implications of cannabinoids, considerable clinical and preclinical analysis is needed to adequately define the physiological, pharmacological, and medicinal aspects of this range of compounds in various disorders covered in this review. This review summarizes the key literature surrounding the role of cannabinoids in the tumor microenvironment and their future promise in cancer treatment