Cardiovascular medication, physical activity and mortality: cross-sectional population study with ongoing mortality follow up

Objective: to establish physical activity levels in relation to cardiovascular medication and to examine if physical activity is associated with benefit independently of medication among individuals with no diagnosis of cardiovascular disease (CVD). Design: Cross-sectional surveys in 1998 and 2003 with ongoing mortality follow up. Setting: Household-based interviews in England and Scotland. Participants: Population samples of adults aged 35 and over living in households, respondents of the Scottish Health Survey and the Health Survey for England. Main outcome measure: Moderate to vigorous physical activity (MVPA) levels and CVD mortality. Results: Fifteen percent (N=3,116) of the 20,177 respondents (8,791 men); were prescribed at least one cardiovascular medication. Medicated respondents were less likely than those unmedicated to meet the physical activity recommendations (OR:0.89, 95%CI: 0.81 to 0.99, p=0.028). The mean follow up (±SD) was 6.6 (2.3) years. There were 1,509 any-cause deaths and 427 CVD deaths. Increased physical activity was associated with all-cause and CVD mortality among both unmedicated (all-cause mortality HR for those with ≥150 min/wk of MVPA compared with those who reported no MVPA): 0.58, 95%CI: 0.48 to 0.69, p<0.001) ; CVD mortality: 0.65, 0.46 to 0.91, p=0.036) and medicated respondents (all-cause death: 0.54, 0.40 to 0.72, p<0.001; CVD death: 0.46 (0.27 to 0.78, p=0.008). Conclusions: Although physical activity protects against premature mortality among both medicated and unmedicated adults, cardiovascular medication is linked with lower uptake of health enhancing physical activity. These results highlight the importance of physical activity in the primary prevention of CVD over and above medication

Physical activity education in the undergraduate curricula of all UK medical schools: are tomorrow's doctors equipped to follow clinical guidelines?

Physical activity (PA) is a cornerstone of disease prevention and treatment. There is, however, a considerable disparity between public health policy, clinical guidelines and the delivery of physical activity promotion within the National Health Service in the UK. If this is to be addressed in the battle against non-communicable diseases, it is vital that tomorrow's doctors understand the basic science and health benefits of physical activity. The aim of this study was to assess the provision of physical activity teaching content in the curricula of all medical schools in the UK. Our results, with responses from all UK medical schools, uncovered some alarming findings, showing that there is widespread omission of basic teaching elements, such as the Chief Medical Officer recommendations and guidance on physical activity. There is an urgent need for physical activity teaching to have dedicated time at medical schools, to equip tomorrow's doctors with the basic knowledge, confidence and skills to promote physical activity and follow numerous clinical guidelines that support physical activity promotion

The descriptive epidemiology of standing activity during free-living in 5412 middle-aged adults: the 1970 British Cohort Study

BACKGROUND: Standing is often classified as light-intensity physical activity, with potential health benefits compared with sitting. Standing is, however, rarely captured as an independent activity. To better understand free-living standing behaviour at a population level, we incorporated a gold standard postural allocation technique into a national cohort study. METHODS: Participants (n=5412, aged 46.8±0.7 years) from the 1970 British Cohort Study were fitted with a water-proofed thigh-mounted accelerometer device (activPAL3 micro) worn 24 hours continuously over 7 days (90.7% provided at least 3 full days). We examined the correlates of free-living standing during waking hours. RESULTS: Total daily standing time averaged 4.6±1.5 h/d, accounting for 29% of waking hours, which was largely (98.7%) accumulated in bouts lasting less than 30 min. In mutually adjusted models, male sex, obesity, diabetes, professional occupation, poor self-rated health and disability were associated with lower device-measured standing times. CONCLUSION: Middle-aged people in Britain spent a surprisingly large proportion of the day in activities involving standing. Standing merits attention as a health-related posture and may represent a potential target for public health intervention

Cold gas in group-dominant elliptical galaxies

We present IRAM 30m telescope observations of the CO(1-0) and (2-1) lines in a sample of 11 group-dominant elliptical galaxies selected from the CLoGS nearby groups sample. Our observations confirm the presence of molecular gas in 4 of the 11 galaxies at >4 sigma significance, and combining these with data from the literature we find a detection rate of 43+-14%, comparable to the detection rate for nearby radio galaxies, suggesting that group-dominant ellipticals may be more likely to contain molecular gas than their non-central counterparts. Those group-dominant galaxies which are detected typically contain ~2x10^8 Msol of molecular gas, and although most have low star formation rates (<1 Msol/yr) they have short depletion times, indicating that the gas must be replenished on timescales ~100 Myr. Almost all of the galaxies contain active nuclei, and we note while the data suggest that CO may be more common in the most radio-loud galaxies, the mass of molecular gas required to power the active nuclei through accretion is small compared to the masses observed. We consider possible origin mechanisms for the gas, through cooling of stellar ejecta within the galaxies, group-scale cooling flows, and gas-rich mergers, and find probable examples of each type within our sample, confirming that a variety of processes act to drive the build up of molecular gas in group-dominant ellipticals.Comment: 9 pages, 5 postscript figures, 4 tables, accepted by A&A. Revised throughout in response to referee's comments, including updates to Table 1 and Figure 4, and addition of Figure

Weekend warrior physical activity pattern and common mental disorder: A population wide study of 108,011 British adults

Abstract Background The dose-response association between physical activity (PA) and mental health is poorly described. We explored cross-sectional associations between physical activity and common mental disorder (psychological distress) in ‘weekend warriors’ who do all their exercise in one or two sessions per week. Methods Adult participants (n = 108,011, age = 47 ± 17 yrs., 46.5% men) were recruited from general population household-based surveys (Health Survey for England and Scottish Health Survey) from 1994 to 2004. Data were pooled and analyzed using logistic regression models. Moderate to vigorous physical activity (MVPA) was self-reported and psychological distress was measured using the 12 item General Health Questionnaire (GHQ-12). Results Psychological distress (GHQ-12 > 3) was prevalent in 14.5% of the sample. In healthy participants an inverse association between PA and psychological distress was optimal at the PA guideline (150 mins/wk. MVPA or 75 min/wk. Vigorous PA) regardless of whether it was accumulated in one or two bouts per week “Weekend warrior” (odd ratio = 0.68, 95% CI, 0.63, 0.73) or as more frequent daily bouts (odd ratio = 0.68, 95% CI, 0.64, 0.72) in comparison to the inactive reference group. In participants with chronic health conditions an inverse association between PA and psychological distress was also evident at lower doses (one or two sessions of PA a week below PA guideline) (OR = 0.72, 95% CI, 0.68, 0.77). Undertaking vigorous intensity PA as part of the PA guideline conferred additional benefit in women (odds ratio = 0.87, 95% CI, 0.75, 1.00), but not men. Conclusion Mental health benefits may be accrued through different PA patterns, thus individual approaches to prescribing exercise should be promoted

Assessment of Magnaporthe grisea mating type by spore PCR

Isolation of DNA from filamentous fungi for PCR analysis is usually time consuming and involves use of toxic chemicals such as phenol/chloroform. In Saccharomyces cerevisiae, PCR assay can be performed with yeast colonies (Huxley et al. TIG 1990 6:236). Here we describe a PCR protocol which uses M. grisea conidia directly for PCR analysis without extraction of DNA

A medium for rapid cleaning of Aspergillus cleistothecia

Aspergillus cleistothecia are usually cleaned of adherent Hülle cells by rolling them on an agar surface, which is a tedious process. We have found that incorporating 0.5 - 1.0 % diatomaceious earth (also caled Celite) into 4% agar, as a mild abrasive, helps to speed cleaning about 5-fold (average 10 min reduced to 2 min)

Laboratory evaluation of stable isotope labeling of Culicoides (Diptera: Ceratopogonidae) for adult dispersal studies.

BackgroundStable isotope labeling is a promising method for use in insect mark-capture and dispersal studies. Culicoides biting midges, which transmit several important animal pathogens, including bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV), are small flies that develop in various semi-aquatic habitats. Previous Culicoides dispersal studies have suffered from the limitations of other labeling techniques, and an inability to definitively connect collected adult midges to specific immature development sites.ResultsAdult C. sonorensis were successfully labeled with 13C and 15N stable isotopes as larvae developing in a semi-aquatic mud substrate in the laboratory. High and low-dose isotope treatments for both elements significantly enriched midges above the background isotope levels of unenriched controls. Enrichment had no effect on C. sonorensis survival, though a slight (~ 5 day) delay in emergence was observed, and there was no significant effect of pool size on 13C or 15N enrichment levels.ConclusionsStable isotope labeling is life-long, and does not interfere with natural insect behaviors. Stable isotope enrichment using 13C or 15N shows promise for Culicoides dispersal studies in the field. This method can be used to identify adult dispersal from larval source habitat where a midge developed. It may be possible to detect a single enriched midge in a pool of unenriched individuals, though further testing is needed to confirm the sensitivity of this method