Binuclear Cu(II) and Co(II) Complexes of Tridentate Heterocyclic Shiff Base Derived from Salicylaldehyde with 4-Aminoantipyrine

New binuclear Co(II) and Co(II) complexes of ONO tridentate heterocyclic Schiff base derived from 4-aminoantipyrine with salicylaldehyde have been synthesized and characterized on the bases of elemental analysis, UV-Vis., FT-IR, and also by aid of molar conductivity measurements, magnetic measurements, and melting points. It has been found that the Schiff bases with Cu(II) or Co(II) ion forming binuclear complexes on (1 : 1) "metal : ligand" stoichiometry. The molar conductance measurements of the complexes in DMSO correspond to be nonelectrolytic nature for all prepared complexes. Distorted octahedral environment is suggested for metal complexes. A theoretical treatment of the formation of complexes in the gas phase was studied, and this was done by using the HyperChem-6 program for the molecular mechanics and semi-empirical calculations. The free ligand and its complexes have been tested for their antibacterial activities against two types of human pathogenic bacteria: the first type (Staphylococcus aureus) is Gram positive and the second type (Escherichia coli) is Gram negative (by using agar well diffusion method). Finally, it was found that compounds show different activity of inhibition on growth of the bacteria

Preparation and Theoretical Study of some Transition Metal Complexes with Acetylenic Amine and Study of its Biological Activity

Abstract Twelve new complexes were synthesized and characterized by reaction salts of with (Cr +5 , Mo +3 and W +6 ) with bidentate ligands (acetylenic amine), these: L1 = (N,L2 = (N, L3 = ( N,L4 = ( N

Water And Alcohol Extraction Of Thyme Plant (Thymus Vulgaris) And Activity Study Against Bacteria, Tumors And Used As Anti-Oxidant In Margarine Manufacture

Isolation had been done for active substances from Thyme plant (Thymus Vulgaris) such as volatile oils, Saponins and Tannins. The percentage in form was (21.1%),(59.2%),( 9.7%) respectively. Also a study of anti-bacterial activity of extracts from Thyme using two types of pathogenic bacteria Escherichia Coli and aurous Staphylococcus showed the ability of inhibition for all different extracts by vary inhibition diameters for different active substances, concentrations and bacteria. One type of cancer cellular line used to study the effect of Thyme  extracts on the growth of cells in the laboratory and thus know the specifications of extracts as anti-tumor, (L20B) cell line have been used which  is mice Transformed cell Line. The possibility of using alcohol extract as anti-oxidant to be add to ghee or vegetable oil, the sensory evaluation and physical results were very good over full year. Keywords: Thymus Vulgaris, Antibacterial and  anticancer activity. Extraction, Anti-Oxidant

PREDICTORS OF HYPOXEMIA IN BRONCHIOLITIS IN A SAMPLE OF IRAQI INFANTS

Background: Bronchiolitis is the first episode of wheezing associated with low grade fever, rhinitis, tachypnea, and increasing respiratory effort in a previously healthy infant during the winter months, and it is the most common lower respiratory tract infection in infancy. Objectives: This study is designed to analyze the clinical signs and symptoms alone or as combinations as possible predictors of severe hypoxemia in infants with bronchiolitis. Patients and methods: This is a prospective study, which was carried out on 96 infants with a mean age of 7.74 ±3.72 months who were admitted to Children Welfare Teaching Hospital in Medical City-Baghdad with bronchiolitis during the period from 1st October 2006 to the 15th March 2007. They are divided into two groups: group one 46 cases (oxygen saturation (SaO2<90) and group two, 50 cases (SaO2≥90).Complete history taken from care taker and full examination done for each patient. A portable oximeter was used to measure oxygen saturation. Results: Forty nine (51%) of patients were males and 47 were females (49%), with male to female ratio of 1.04:1. The mean age was (7.745±3.7) months. The mean oxygen saturation was (90%), with a median of (84.7%) and a range of (76%-89%) in group one (SaO2<90), while it was (95.32%) with a range of (90%-99%) in group two (SaO2≥90). Conclusions: Reduced ability to feed, sleep disturbances, hypotonia and clinical signs as suprasternal retractions, continuous nasal flaring, tachypnea, grunting, head nodding and cyanosis appeared to be statistically highly significant in this study as predictors of severe hypoxemia. Combinations of signs and symptoms that showed statistically significant association with severe hypoxemia were: grunting or head nodding, cyanosis or head nodding, tachypnea or sleep disturbance, tachypnea or suprasternal retractions, and tachypnea or head nodding (p.value <0.0001) for all mentioned combinations, So we recommend to use these combinations of signs and symptoms as significant predictors of severe hypoxemia especially when pulse oximetry is not available

Antibacterial Activity of Small Molecules Which Eradicate Methicillin-Resistant Staphylococcus aureus Persisters

The serious challenge posed by multidrug-resistant bacterial infections with concomitant treatment failure and high mortality rates presents an urgent threat to the global health. We herein report the discovery of a new class of potent antimicrobial compounds that are highly effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The compounds were efficiently synthesized in one-pot employing a cascade of Groebke-Blackburn-Bienayme and aza-Michael addition reactions. Phenotypic screening of the pilot library against various bacterial species including methicillin-sensitive and MRSA strains, has identified potent chemotypes with minimal inhibitory concentrations (MIC) of 3.125-6.25 mu g/ml. The most potent compounds were fast-acting at eradicating exponentially growing MRSA, with killing achieved after 30 min of exposure to the compounds. They were also able to kill MRSA persister cells which are tolerant to most available medications. Microscopic analysis using fluorescence microscope and atomic force microscope indicate that these compounds lead to disruption of bacterial cell envelopes. Most notably, bacterial resistance toward these compounds was not observed after 20 serial passages in stark contrast to the significant resistance developed rapidly upon exposure to a clinically relevant antibiotic. Furthermore, the compounds did not induce significant hemolysis to human red blood cells. In vivo safety studies revealed a high safety profile of these motifs. These small molecules hold a promise for further studies and development as new antibacterial agents against MRSA infections.This work was supported by the generous grants from the IsDB-Transformers Fund and the Research Funding Department, University of Sharjah, UAE (CoV19-0306)

Twice-daily insulin glargine for patients with uncontrolled type 2 diabetes mellitus.

Insulin glargine is recombinant human insulin analog that is commonly used in patients with type 2 diabetes as well as those with type 1 diabetes. Pharmacokinetic and pharmacodynamics studies of insulin glargine had shown that it has an onset of action that ranged from 1.2 to 1.8 h while its duration of action is 18 to 26 h. Because of its long duration of action insulin glargine is usually prescribed once daily. However, several reports have shown that the administration of insulin glargine once daily is not enough to achieve adequate glucose control in some patients requiring a twice daily dosing. The first report on using insulin glargine twice daily was published shortly after its availability. It described a patient with type 1 diabetes who had consistently elevated bedtime glucose values on once daily insulin glargine administered in the evening. There was significant improvement in glucose values after changing the frequency of insulin glargine to twice daily as a split dose every 12 h. Albright and colleagues found that twice daily glargine therapy was required in patients with type 1 diabetes who developed morning hypoglycemia and/or afternoon hyperglycemia while on once daily therapy; the twice daily regimen was associated with a significant reduction in HbA1c levels compared to patients who were on once daily therapy

Home cancer care research: a bibliometric and visualization analysis (1990-2021)

Home cancer care research (HCCR) has accelerated, as considerable attention has been placed on reducing cancer-related health costs and enhancing cancer patients' quality of life. Understanding the current status of HCCR can help guide future research and support informed decision-making about new home cancer care (HCC) programs. However, most current studies mainly detail the research status of certain components, while failing to explore the knowledge domain of this research field as a whole, thereby limiting the overall understanding of home cancer care. We carried out bibliometric and visualization analyses of Scopus-indexed papers related to home cancer care published between 1990-2021, and used VOSviewer scientometric software to investigate the status and provide a structural overview of the knowledge domain of HCCR (social, intellectual, and conceptual structures). Our findings demonstrate that over the last three decades, the research on home cancer care has been increasing, with a constantly expanding stream of new papers built on a solid knowledge base and applied to a wide range of research themes

The Association between Zinc and Copper and Cardiometabolic Risk Factors in Adults

Cardiometabolic risk (CMR) factors increase the likelihood of developing cardiovascular diseases (CVD). In Qatar, 24% of the total deaths are attributed to CVDs. Several nutritional disturbances have been linked to high risk of CVD. Many studies have discussed the effects of zinc (Zn) and copper (Cu) on CMR factors; however, evidence has been controversial. This investigated the association between CMR factors and the status of Zn, Cu, and Zn/Cu ratio. A total of 575 Qatari adults (?18 years) were obtained from Qatar Biobank. Plasma levels of Zn and Cu were determined using inductively coupled plasma mass spectrometry (ICP-MS). Anthropometric data and CMR factors were determined using standard methods. Adjusted associations between minerals and CMR were estimated by logistic regression. The associations' strength was tested using partial correlation. Zn was not strongly correlated (p-value?0.01) or significantly associated with CMR factors and metabolic syndrome (MetS). Cu levels correlated positively with body mass index (BMI) (0.23; p?0.001), pulse rate (PR) (0.18; p?0.001), total cholesterol (0.13; p=0.01), and high-density lipoproteins (HDL) (0.27; p?0.001); and negatively with diastolic blood pressure (DBP) (?0.13; p=0.01). High Cu significantly decreased the risk of MetS (0.121; p?0.001). Furthermore, Zn/Cu ratio positively correlated with waist circumference (0.13; p=0.01), systolic blood pressure (0.13; p?0.01), and DBP (0.14; p?0.01); and negatively with BMI (?0.19; p?0.001), PR (?0.17; p?0.001), and HDL (?0.27; p?0.001). High Zn/Cu ratio increased the prevalence of low HDL (4.508; p?0.001) and MetS (5.570; p?0.01). These findings suggest that high Cu levels are associated with a protective effect on DBP, HDL, and MetS and that high plasma Zn/Cu ratio is associated with the risk of low HDL and MetS. We recommend future studies to focus on minerals status among abdominally obese and prediabetic subjects because of the probable link between low serum Zn and Cu and insulin resistance and CVD

S. Cheema et al .

Objectives Oral health is a crucial determinant of quality of life. We aimed to determine oral health condition and factors associated with poor oral status in the adult national population of Qatar. Methods We used data from the World Health Organization supported STEPS (STEPwise approach to Surveillance) Survey conducted by the Supreme Council of Health, Qatar in 2012. A total of 2,496 Qataris (1,053 men, 1,443 women) answered the national survey. The Rao-Scott Chi-Square test was used to analyze oral health characteristics and multinomial logistic regression to assess risk factors. Results The self-perceived oral status of approximately 40 percent of respondents was either "average" or "poor" rather than "good." Poor oral status was more often reported by women (OR = 1.93; 95%CI = 1.30-2.80), by older (OR = 3.38; 95%CI = 1.59-7.19) and less educated respondents (OR = 3.58; 95%CI = 2.15-5.96). Other risk groups included people with diabetes (OR = 1.87; 95%CI = 1.24-2.81), smokeless tobacco users (OR = 3.90; 95%CI = 1.75-8.68), or ever tobacco users (OR = 1.66; 95%CI = 1.03-2.67). Oral health status appeared to be independent of diet, BMI status, and history of hypertension. Difficulties and behaviors related to oral health were more frequently reported by women than by men. These included pain (P < 0.001), difficulty chewing (P < 0.001), and discomfort over appearance of teeth (P < 0.001). Participants used toothbrushes, toothpicks, dental floss, and miswak to maintain oral hygiene. Conclusion Our results provide evidence that oral health remains a public health concern in Qatar

Shear behavior of steel fiber reinforced concrete using full-field displacements from digital image correlation

Reinforced concrete beams with discrete hooked-end steel fibers at 0.5% volume fraction are tested with a shear span to depth (a/d) ratio equal to 1.8. Digital image correlation (DIC) technique was used to obtain the full-filed displacements from the beam. The formation and propagation of a shear crack which directly influences the load response and the peak load in the load response of the beam is monitored using the displacement information available from DIC. There is a continuous increase in slip across the crack faces with increasing load, which produces an increase in the crack opening. The dilatant behavior indicated by the proportion of crack opening to slip displacement obtained from the control and the SFRC beams is identical. Failure in control beams is brittle and was produced by the opening of dominant shear crack within the shear span. At the peak load, the shear crack pattern in fiber reinforced concrete is identical to the crack pattern in the control beam. The fiber reinforced concrete beams exhibit post peak load carrying capacity with continued slip of the dominant shear crack. The crack bridging stress provided by the fibers results in a significant increase shear transfer across the crack which provides significant post-peak load carrying capacity with increasing slip of the shear crack