Paralysis over Palestine: Questions of Strategy

This essay by a prominent Israeli activist grows out of concern that advocacy efforts in support of the Palestinian cause have remained stuck at the protest-informational stage of combating disparate manifestations of the occupation. What is needed, the author argues, is a strategy to mobilize the vast range of civil society groups -- Palestinian, Israeli, and international -- to forge an effective lobbying and advocacy force that can lend the Palestinian leadership public support and a measure of parity with Israel. Intended as a starting point for debate, the essay explores the possibilities of a "middle range" strategy that would articulate the essential "red line" elements crucial to any just and sustainable settlement, provide a coordinated strategy of advocacy, and explore a range of "endgames," including a regional approach to resolving the conflict if the "two-state solution" is found to be impossible because of irreversible "facts on the ground.

How Do Homebuyers Value Different Types of Green Space?

It is important to understand tradeoffs in preferences for natural and constructed green space in semi-arid urban areas because these lands compete for scarce water resources. We perform a hedonic study using high resolution, remotely-sensed vegetation indices and house sales records. We find that homebuyers in the study area prefer greener lots, greener neighborhoods, and greener nearby riparian corridors, and they pay premiums for proximity to green space amenities. The findings have fundamental implications for the efficient allocation of limited water supplies between different types of green space and for native vegetation conservation in semi-arid metropolitan areas.hedonic model, locally weighted regression, spatial, open space, golf course, park, riparian, Consumer/Household Economics, Land Economics/Use,

Untangling the Nuisance Knot

Commentators have long characterized the law of nuisance as a muddled and confusing doctrine, limited to deciding a few landuse disputes not already resolved by zoning. In 1992, interest in the doctrine was renewed when the U.S. Supreme Court in Lucas v. South Carolina Coastal Council declared nuisance the key to the difficult question of when legislation amounted to an uncompensated taking of real property. It has thus become important to understand both the nuisance doctrine and the confusion surrounding its application. In this article, the author locates the source of the confusion in three problems stemming from the strict liability standard by which landuse disputes were originally governed in the English common law of nuisance. First, the application of nuisance doctrine to the landuse disputes inevitably accompanying the economic transformation of American society from agriculture to industry called for a modification, though not an abandonment, of strict liability. Second, bench and bar tangled over whether the remnants of strict liability in nuisance could moderate some of the negligence doctrines that weighed most heavily on tort plaintiffs. Third, attempts by the drafters of the Restatement (First and Second) of Torts to rationalize the doctrine with a single rule applicable to the law of both accidents and landuse disputes failed. Understanding these three forces may help both judge and practitioner discover a principled understanding of this newly-relevant area of law as they use nuisance to assess takings claims under Lucas

Age-related differences of microRNA-21 in leukocytes and its association with physical performance

INTRODUCTION: Several studies suggest chronic inflammation as an underlying biological mechanism for the decline in physical performance of elderly (Cesari et al., 2004; Tiainen et al., 2010). Moreover, it has been shown that habitual exercise ameliorates the higher proinflammatory gene expression in leukocytes of elderly (Gano et al., 2011). Within the last years several microRNAs (short, non-coding RNAs) have been demonstrated to regulate gene expression also in the context of exercise immunology (Wessner et al., 2010). Interestingly, some of these microRNAs (miRs) such as miR-21 and miR-146 are involved in pathways important for ageing as well as inflammatory processes (Olivieri et al. 2012). Therefore, the main aims of the current study were (1) to investigate whether miR-21 and miR-146 levels in leukocytes are affected by age and (2) to correlate performance levels of elderly to miR gene expression levels. METHODS: Healthy young (n=7, age: 25.28 ± 2.3 years) and old (n=25, age: 83.40 ± 5.63 years) females participated in the study. After an overnight fast, leukocytes were isolated from heparinized blood using BD Vacutainer CPT tubes. miR-21 and miR146 gene expression in leukocytes was determined by quantitative RT-PCR using miScript Primer Assays (Qiagen, Hilden, Germany). Additonally, leukocyte numbers and inflammatory markers (hs-CRP, hs-IL6, IL1-ra) were quantified. In order to relate potential inflammtaory markers to the fitness level of the elderly, several functional tests were performed (handgrip, 6min walking test, chair-rise test, isokinetic measurement of knee extension and flexion). Differences between groups were detected by unpaired t-tests. Correlations between markers were characterized using Pearson correlation coefficients. RESULTS: Interestingly, miR-21 expression in leukocytes was significantly enhanced in the elderly (+55.1%, p=0.036) while miR-146a levels were not affected by age (p=0.492). However, miR-21 correlated signifantly with hs-CRP levels (r=0.352; p=0.033), we did not detect any associations between miR-21 expression and performance parameters of the elderly: Handgrip (r=0.533; p=0.121), 6-min Walking Test (r=0.231; p=0.220), Chair Rise (r=0.336; p=0.070), Peak Torque knee extension (r=0.589; p=0.105) as well as flexion (r=0.203; p=0.291). CONCLUSION: In conclusion these preliminary results show that miR-21 seems to be enhanced with age but not influenced by fitness level of the elderly. Gene targets of miR-21 have been identified in the TGF-β signaling pathway. Therefore, next steps would be to associate the changes in miR-21with its potential targets to further elucidate its role in the ageing process

Non-Destructive Thickness Uniformity Measurement of Photosensitive Gelatin Film

Volume phase holographic gratings (VPHG’s) depend on dichromate gelatin of which uniform thickness is vital. The photosensitive nature of the film makes current thin film measurement devices not viable for production means. This project attempts to create a non-destructive measurement of photosensitive gelatin film used in VPHG production. Application of thin film interference at chosen wavelengths enable analysis of uniformity by comparison between the thin film inference patterns at different wavelengths. An initial proof of concept was established and a path towards a production ready device is outlined