The handbook for standardised field and laboratory measurements in terrestrial climate-change experiments and observational studies

Climate change is a worldwide threat to biodiversity and ecosystem structure, functioning, and services. To understand the underlying drivers and mechanisms, and to predict the consequences for nature and people, we urgently need better understanding of the direction and magnitude of climate‐change impacts across the soil–plant–atmosphere continuum. An increasing number of climate‐change studies is creating new opportunities for meaningful and high‐quality generalisations and improved process understanding. However, significant challenges exist related to data availability and/or compatibility across studies, compromising opportunities for data re‐use, synthesis, and upscaling. Many of these challenges relate to a lack of an established “best practice” for measuring key impacts and responses. This restrains our current understanding of complex processes and mechanisms in terrestrial ecosystems related to climate change

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

An Indication of Anisotropy in Arrival Directions of Ultra-high-energy Cosmic Rays through Comparison to the Flux Pattern of Extragalactic Gamma-Ray Sources

A new analysis of the data set from the Pierre Auger Observatory provides evidence for anisotropy in the arrival directions of ultra-high-energy cosmic rays on an intermediate angular scale, which is indicative of excess arrivals from strong, nearby sources. The data consist of 5514 events above 20 EeV with zenith angles up to 80 degrees. recorded before 2017 April 30. Sky models have been created for two distinct populations of extragalactic gamma-ray emitters: active galactic nuclei from the second catalog of hard Fermi-LAT sources (2FHL) and starburst galaxies from a sample that was examined with Fermi-LAT. Flux-limited samples, which include all types of galaxies from the Swift-BAT and 2MASS surveys, have been investigated for comparison. The sky model of cosmic-ray density constructed using each catalog has two free parameters, the fraction of events correlating with astrophysical objects, and an angular scale characterizing the clustering of cosmic rays around extragalactic sources. A maximum-likelihood ratio test is used to evaluate the best values of these parameters and to quantify the strength of each model by contrast with isotropy. It is found that the starburst model fits the data better than the hypothesis of isotropy with a statistical significance of 4.0 sigma, the highest value of the test statistic being for energies above 39 EeV. The three alternative models are favored against isotropy with 2.7 sigma-3.2 sigma significance. The origin of the indicated deviation from isotropy is examined and prospects for more sensitive future studies are discussed

Modulation of potassium channels in isolated rabbit aortic myocytes

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Developmental sensitivity to temporal grouping effects in short-term memory.

Four experiments investigate developmental changes in the effect of providing time-based cues to lists for immediate recall. Data both provide a context for adult research and have implications for children’s memory processes. Sets of letters (Experiments 1-3) or numbers (Experiment 4) were presented to children with either regular inter-item temporal intervals (ungrouped lists) or pauses to segment sets (grouped lists). Experiment 1 indicated a developmental shift between 4 and 8 years of age, with an increasing recall bene"t from temporal group structure for visually presented "xed-length lists. Experiment 2 confirmed the developmental shift with visual presentation using a span procedure, with sensitivity to temporal grouping becoming apparent by the age of 8 years. Experiments 3 and 4 revealed a similar developmental pattern with a span procedure using auditory stimuli. In summary, children capitalise on pauses in visual and auditory material at approximately the same age. There was no evidence that auditory presentation induces a fundamentally different grouping process or precocious strategy use, contrary to some previous accounts. Data are most consistent with the argument that grouping is a relatively late-developing, strategic process

Children's cultural background knowledge and story telling performance

Contains fulltext : 62989.pdf (publisher's version ) (Closed access)The cultural context in which a child is raised influences her cognitive system and language behavior. In this paper, we explored the influence of cultural back ground knowledge on story telling performance of two groups of children living in the Netherlands: (1) bilingual ethnic minority children from immigrant families of Islamic background(2) monolingual Dutch children. Using a within-subject design, all children retold, continued, and finished three story beginnings: One story dealt with a topic related to the ethnic minority children's cultural background(Ramadan), one story dealt with a topic related to the Dutch children's cultural background(Carnival), and one story dealt with a topic both groups of children were familiar with (playing at the schoolyard). All children spoke in Dutch, which implies that the ethnic minority children performed all tasks in a language other than their family language, whereas the Dutch children performed the same tasks in their native language. It appeared that both quantitative and qualitative characteristics of the stories were influenced by the children's cultural background knowledge. Measurements of story length showed that ethnic minority children's Ramadan stories were longer than their Carnival stories, whereas Dutch children's Carnival stories were longer than their Ramadan stories. Likewise, the ethnic minority children's Ramadan stories containedmore connective ties(as indexed by the number of conjunctions used) than their Carnival stories, whereas the reverse pattern was observed in Dutch children. These findings indicate that cultural familiarity with a topic influences story telling performance in terms of story length and coherence.21 p