Long-term effects of acute ischemia and reperfusion injury

Long-term effects of acute ischemia and reperfusion injury. Ischemia reperfusion (I/R) injury plays a major role in delayed graft function and long-term changes after kidney transplantation. By using different therapeutic strategies to prevent I/R injury in rat models of kidney transplantation we studied relationships between inflammatory cell arrival and adhesion molecule expression. In other rat models for acute renal failure we investigated the effect of up-regulation of protective genes such as heme oxygenase-1 (HO-1) on infiltrating cells, showing that infiltrating cells also contribute to beneficial effects. In order to gain more insight into the complex mechanisms of long-term changes after kidney transplantation, we started a protocol biopsy program to study histologic changes 6, 12, and 26 weeks after transplantation. The following article clarifies some of the complex mechanisms contributing to long-term changes caused by I/R injury

"Kirchenzwang" und "Religionsfreiheit" im Lichte des "historischen Moments" : eine zeitgemässe Betrachtung, den baltischen Heimathgenossen zur Verständigung dargeboten

https://www.ester.ee/record=b2074990*es

Bist du getauft?

https://www.ester.ee/record=b1918579*es

Got milk? Breastfeeding and milk analysis of a mother on chronic hemodialysis

Purpose: Women on dialysis rarely become pregnant. However, the overall rate of successful pregnancies is increasing in this patient population and breastfeeding becomes an option for mothers on dialysis. In this study we performed a systematic breast milk composition analysis of a mother on chronic hemodialysis (HD). Methods: Specimens of breast milk and blood were collected in regular intervals before and after HD from a 39-year old woman starting on day 10 postpartum. Samples were analyzed for electrolytes, retention solutes, nutrients and other laboratory measurements. Breast milk samples from low-risk mothers matched for postpartum age were used as controls. Results: Significantly higher levels of creatinine and urea were found in pre-HD breast milk when compared to post-HD. A similar post-dialytic decrease was only found for uric acid but not for any other investigated parameter. Conversely, sodium and chloride were significantly increased in post-HD samples. Compared to controls creatinine and urea were significantly higher in pre-HD samples while the difference remained only significant for post-HD creatinine. Phosphate was significantly lower in pre- and post-HD breast milk when compared to controls, whereas calcium showed no significant differences. In terms of nutrient components glucose levels showed a strong trend for a decrease, whereas protein, triglycerides and cholesterol did not differ. Similarly, no significant differences were found in iron, potassium and magnesium content. Conclusion: To the best of our knowledge this is the first report on a breastfeeding mother on chronic dialysis. Although we found differences in creatinine, urea, sodium, chloride and phosphate, our general analysis showed high similarity of our patient’s breast milk to samples from low-risk control mothers. Significant variations in breast milk composition between pre- and post-HD samples suggest that breastfeeding might be preferably performed after dialysis treatment. In summary, our findings indicate that breastfeeding can be considered a viable option for newborns of mothers on dialysis

De ranula sublinguali : dissertatio inauguralis

http://tartu.ester.ee/record=b1911266~S1*es

Got milk? Breastfeeding and milk analysis of a mother on chronic hemodialysis

Purpose: Women on dialysis rarely become pregnant. However, the overall rate of successful pregnancies is increasing in this patient population and breastfeeding becomes an option for mothers on dialysis. In this study we performed a systematic breast milk composition analysis of a mother on chronic hemodialysis (HD). Methods: Specimens of breast milk and blood were collected in regular intervals before and after HD from a 39-year old woman starting on day 10 postpartum. Samples were analyzed for electrolytes, retention solutes, nutrients and other laboratory measurements. Breast milk samples from low-risk mothers matched for postpartum age were used as controls. Results: Significantly higher levels of creatinine and urea were found in pre-HD breast milk when compared to post-HD. A similar post-dialytic decrease was only found for uric acid but not for any other investigated parameter. Conversely, sodium and chloride were significantly increased in post-HD samples. Compared to controls creatinine and urea were significantly higher in pre-HD samples while the difference remained only significant for post-HD creatinine. Phosphate was significantly lower in pre- and post-HD breast milk when compared to controls, whereas calcium showed no significant differences. In terms of nutrient components glucose levels showed a strong trend for a decrease, whereas protein, triglycerides and cholesterol did not differ. Similarly, no significant differences were found in iron, potassium and magnesium content. Conclusion: To the best of our knowledge this is the first report on a breastfeeding mother on chronic dialysis. Although we found differences in creatinine, urea, sodium, chloride and phosphate, our general analysis showed high similarity of our patient’s breast milk to samples from low-risk control mothers. Significant variations in breast milk composition between pre- and post-HD samples suggest that breastfeeding might be preferably performed after dialysis treatment. In summary, our findings indicate that breastfeeding can be considered a viable option for newborns of mothers on dialysis

Szexuális motiváció nyomai a tetthelyen: kriminálpszichológiától a kriminalisztikáig

In this paper, we examine the question whether criminal psychology can become an auxiliary science of criminalistics in the future. The issue is not trivial, as none of the criminalistic studies. we have examined. pays particular attention to psychology. But in the UK, criminal psychology seems already to be one of the resources of criminalistics. We examine the issue through the presentation of the first results of one of our ongoing research projects. By using a machine-learning approach we show that the motivation for homicide can be predicted with a precision of over 90% based solely on on-site clues. We believe that this, perhaps modest, research result goes beyond itself and raises the possibility that continuation and completion of the research may turn criminal psychology into a resource of criminalistics in Hungary, as well, probably the second time in the world.Jelen tanulmányban azt a kérdést vizsgáljuk meg, hogy a kriminálpszichológia a kriminalisztika segédtudományává válhat-e a jövőben. A kérdés nem triviális, ugyanis egyetlen általunk vizsgált kriminalisztikai tanulmány vagy kézikönyv sem szentel különösebb figyelmet a kriminálpszichológiának, ugyanakkor az Egyesült Királyságban – úgy tűnik – a kriminálpszichológia már ma is a kriminalisztika egyik erőforrása. A kérdést egy folyó kutatási projektünk első eredményeinek bemutatásán keresztül vizsgáljuk meg. Kutatásunk azt mutatja, hogy a mesterséges intelligencia felhasználásával 90% fölötti valószínűséggel azonosítani tudjuk az emberölés motivációját pusztán a helyszíni nyomok alapján. Úgy véljük, hogy ez az önmagában talán szerény kutatási eredmény túlmutat önmagán, és felveti annak lehetőségét, hogy a kutatás folytatása és kiteljesítése talán Magyarországon is a kriminalisztika erőforrásává változtathatja a kriminálpszichológiát, a világon valószínűleg másodjára