Aspects of the monastic patronage of the English and French royal houses 1130-1270.

PhDThis study takes as its theme the relationship of the English and French kings and the religious orders, c.1130-1270, Patronage in general is a field relatively neglected in the rich literature on the monastic life, and royal patronage has never before been traced over a broad period for both France and England. The chief concern here is with royal favour shown towards the various orders of monks and friars, in the foundations and donations made by the kings. This is put in the context of monastic patronage set in a wider field, and of the charters and pensions which are part of its formal expression. The monastic foundations and the general pattern of royal donations to different orders are discussed in some detail in the core of the work; the material is divided roughly according to the reigns of the kings. Evidence from chronicles and the physical remains of buildings is drawn upon as well as collections of charters and royal financial documents. The personalities and attitudes of the monarchs towards the religious hierarchy, the way in which monastic patronage reflects their political interests, and the contrasts between English and French patterns of patronage are all analysed, and the development of the royal monastic mausoleum in Western Europe is discussed as a special case of monastic patronage. A comparison is attempted of royal and non-royal foundations based on a statistical analysis. The siting and architectural style of royal monasteries, the political implications of monastic patronage, and the extent to which royal patronage affected religious orders are also examined; finally there is a brief treatment of royal patronage after c.1270. Transcripts of imprinted charters and photographs of royal monasteries are included as pièces justificatives

High frequency environmental DNA metabarcoding provides rapid and effective monitoring of fish community dynamics

Long‐term monitoring is critical to measure the response of biodiversity patterns and processes to human‐mediated environmental pressures. This is particularly pertinent in freshwaters, where recent estimates indicated a third of all fish species are threatened with extinction, making ongoing biomonitoring essential for conservation management. High frequency annual monitoring is critical for identifying temporal changes in fish community composition; however, traditional survey methods are typically less practical over such timeframes. While environmental (e)DNA measurement represents a potentially powerful tool for monitoring temporal community dynamics, studies are lacking. To address this deficit, we generated a high frequency time‐series dataset of entire fish communities using eDNA metabarcoding, to directly assess the repeatability and sensitivity of this method for detecting annual population trends. We targeted two differing environments (freshwater vs. intertidal) within the Thames catchment, UK, where detailed historical records from traditional monitoring were available for comparison. To test how robust eDNA data is for inferring the known community, we applied a hierarchical, nested design encompassing short and longer‐term variation in eDNA data. Our analyses showed that irrespective of environment, eDNA metabarcoding represented known seasonal shifts in fish communities, where increased relative read abundance of eDNA coincided with known migratory and spawning events, including those of the critically endangered native species Anguilla anguilla (European eel). eDNA species detections across a single year included over 75% of species recorded in a ca. 30‐year historical dataset, highlighting the power of eDNA for species detection. Our findings provide greater insight into the utility of eDNA metabarcoding for recovering temporal trends in fish communities from dynamic freshwater systems and insight into the potential best sampling strategy for future eDNA surveys

A systematic review of selected interventions to reduce juvenile re-offending. Technical Report.

What do we want to know? Persistent juvenile re-offending remains an area of concern for public policy, due to the social, economic and health impacts of such offending on victims and offenders. A large proportion of criminal offences are committed by repeat offenders. The broad purpose of this systematic review was to review the research evidence on a selected range of interventions to reduce re-offending by juveniles to try and identify more effective interventions. What did we find and what are the implications? When compared to standard diversion (caution and monitoring) there was consistent evidence of reductions in re-offending from the following intervention: Pre-sentencing diversion with personal skills training and reparation The intervention included: - personal skills training/ counselling about anger management, personal responsibility and decision making. - some form of reparation to the community/ victim of crime. - family involvement. When compared to standard residential placement there was consistent evidence of reductions in re-offending from the following intervention: • Community based family residential placement for female juvenile offenders The intervention included: - residential placement for six months to a year in small group supportive ‘family type’ environment. - personal skills training/counselling which is about anger management, personal responsibility and decision making. - monitoring and use of appropriate incentives and sanctions. Promising effects The following interventions were classified as having promising positive effects with limited or inconsistent evidence: • ‘Teen Courts’ compared to other diversion • Community based family residential placements compared to standard residential placements for male juvenile offenders Insufficient evidence There was insufficient evidence identified to assess the impact of the following interventions: • Secure incarceration compared to community sentence • Psycho-dynamic counselling compared to normal court interventions • Pre-sentence diversions compared to court community sentence • Multi-component diversion for persistent offenders (comparison not clear) • Multi-component diversion for mixed groups of offence severity (comparison not clear) • Supported transition from secure incarceration to community compared to no or limited support • Probation plus sports counselling compared to probation only • Violence re-education programme compared to court imposed community service What are the implications? The results suggest that those interventions where there is consistent evidence of beneficial effect could be priorities for possible implementation accompanied by rigorous evaluation in the UK context as the evidence on the effects of this intervention in this review all came from the USA. The ‘promising’ interventions could be considered priorities for further rigorous evaluation. How did we get these results? The review was undertaken in a number of stages. The first stage consisted of identifying all studies that met the review inclusion criteria published between 1998 and 2007. Descriptive information about these studies was collected and used as a ‘map’ of research in the field of interventions to reduce juvenile re-offending. At this point there were 94 studies included the map. A further round of coding was undertaken to help identify sub-groups of studies. The results of this coding were discussed with the steering group and a decision was made at that point to focus on a number of subgroups for the in-depth review. At this stage detailed data extraction was undertaken to assess the quality of the studies and facilitate synthesis of the findings of the selected studies in order to provide answers to the review questions

Shared neural processes support semantic control and action understanding

Executive-semantic control and action understanding appear to recruit overlapping brain regions but existing evidence from neuroimaging meta-analyses and neuropsychology lacks spatial precision; we therefore manipulated difficulty and feature type (visual vs. action) in a single fMRI study. Harder judgements recruited an executive-semantic network encompassing medial and inferior frontal regions (including LIFG) and posterior temporal cortex (including pMTG). These regions partially overlapped with brain areas involved in action but not visual judgements. In LIFG, the peak responses to action and difficulty were spatially identical across participants, while these responses were overlapping yet spatially distinct in posterior temporal cortex. We propose that the co-activation of LIFG and pMTG allows the flexible retrieval of semantic information, appropriate to the current context; this might be necessary both for semantic control and understanding actions. Feature selection in difficult trials also recruited ventral occipital-temporal areas, not implicated in action understanding

Shared neural processes support semantic control and action understanding

Executive-semantic control and action understanding appear to recruit overlapping brain regions but existing evidence from neuroimaging meta-analyses and neuropsychology lacks spatial precision; we therefore manipulated difficulty and feature type (visual vs. action) in a single fMRI study. Harder judgements recruited an executive-semantic network encompassing medial and inferior frontal regions (including LIFG) and posterior temporal cortex (including pMTG). These regions partially overlapped with brain areas involved in action but not visual judgements. In LIFG, the peak responses to action and difficulty were spatially identical across participants, while these responses were overlapping yet spatially distinct in posterior temporal cortex. We propose that the co-activation of LIFG and pMTG allows the flexible retrieval of semantic information, appropriate to the current context; this might be necessary both for semantic control and understanding actions. Feature selection in difficult trials also recruited ventral occipital-temporal areas, not implicated in action understanding

Opening doors to nature: Bringing calm and raising aspirations of vulnerable young people through nature-based intervention

This qualitative study explores the experiences of YMCA residents who participated in a nature-based intervention designed to support wellbeing run by Derbyshire Wildlife Trust and YMCA Derbyshire. The intervention ran over 9 weeks and involved taking groups of residents off site for a range of outdoor activities from allotment gardening to nature conservation in various outdoor environments.  After the intervention took place semi-structured interviews, which explored the personal journeys of 8 residents who had participated in the intervention, were conducted. An IPA analysis of the interviews identified three superordinate themes: building social relationships, developing skills and developing feelings of self-worth and managing emotions through nature. It is argued that the intervention enabled the residents to feel part of a supportive community which enabled a positive shift in identity. Furthermore, the programme helped residents manage their emotions, supporting their mental health and promoting a general sense of wellbeing. This is especially important, given that members of the intervention have a history of mental health issues and often come from a background of higher socio-economic deprivation, where opportunities for social cohesion and nature connectedness are scarce. N/

Control the source: Source memory for semantic, spatial and self-related items in patients with LIFG lesions.

Patients with multimodal semantic deficits following stroke ('semantic aphasia') have largely intact knowledge, yet difficulty controlling conceptual retrieval to suit the circumstances. Although conceptual representations are thought to be largely distinct from episodic representations of recent events, controlled retrieval processes may overlap across semantic and episodic memory domains. We investigated this possibility by examining item familiarity and source memory for recent events in semantic aphasia following infarcts affecting left inferior frontal gyrus. We tested the hypothesis that the nature of impairment in episodic judgements reflects the need for control over retrieval: item familiarity might be relatively intact, given it is driven by strong cues (re-presentation of the item), while source recollection might be more impaired since this task involves resolving competition between several potential sources. This pattern was observed most strongly when the degree of competition between sources was higher, i.e., when non-meaningful sources had similar perceptual features, and existing knowledge was incongruent with the source. In contrast, when (i) spatial location acted as a strong cue for retrieval; (ii) existing knowledge was congruent with episodic memory and (iii) distinctiveness of sources was increased by means of self-referential processing, source memory reached normal levels. These findings confirm the association between deregulated control of semantic and episodic memory in patients with semantic aphasia and delineate circumstances that ameliorate or aggravate these deficits

Representing Representation : Integration between the Temporal Lobe and the Posterior Cingulate Influences the Content and Form of Spontaneous Thought

When not engaged in the moment, we often spontaneously represent people, places and events that are not present in the environment. Although this capacity has been linked to the default mode network (DMN), it remains unclear how interactions between the nodes of this network give rise to particular mental experiences during spontaneous thought. One hypothesis is that the core of the DMN integrates information from medial and lateral temporal lobe memory systems, which represent different aspects of knowledge. Individual differences in the connectivity between temporal lobe regions and the default mode network core would then predict differences in the content and form of people's spontaneous thoughts. This study tested this hypothesis by examining the relationship between seed-based functional connectivity and the contents of spontaneous thought recorded in a laboratory study several days later. Variations in connectivity from both medial and lateral temporal lobe regions was associated with different patterns of spontaneous thought and these effects converged on an overlapping region in the posterior cingulate cortex. We propose that the posterior core of the DMN acts as a representational hub that integrates information represented in medial and lateral temporal lobe and this process is important in determining the content and form of spontaneous thought

When comprehension elicits incomprehension: Deterioration of semantic categorisation in the absence of stimulus repetition

Repetition improves retrieval from memory; however, under some circumstances, it can also impair performance. Separate literatures have investigated this phenomenon, including studies showing subjective loss of meaning following “semantic satiation”, slowed naming and categorisation when semantically-related items are repeated, and semantic “access deficits” in aphasia. Such effects have been variously explained in terms of habituation of repeatedly-accessed representations, increased interference from strongly activated competitors, and longer-term weight changes reflecting the suppression of non-targets on earlier trials (i.e., retrieval-induced forgetting). While studies of semantic satiation involve massed repetition of individual items, competition and weight changes at the conceptual level should elicit declining comprehension for non-repeated items: this pattern has been demonstrated for picture naming but effects in categorisation are less clear. We developed a paced serial semantic task (PSST), in which participants identified category members amongst distracters. Performance in healthy young adults deteriorated with ongoing retrieval for non-repeated words belonging to functional categories (e.g., picnic), taxonomic categories (e.g., animal) and feature-based categories (e.g., colour red – “tomato”, “post box”). This decline was greatest at fast presentation speeds (when there was less time to overcome competition/inhibition), and for strongly-associated targets (which may have accrued more inhibition to facilitate earlier target categorisation). Deteriorating performance was also seen across words and pictures, consistent with a conceptual locus. We observed a release from deteriorating categorisation following a switch to a new category, demonstrating that this was not a general effect of time on task. Patients with semantic aphasia, who have deficient semantic control, maintained their performance throughout the categories, unlike younger adults: this finding is hard to reconcile with accounts of declining performance that propose a build-up of competition, since the patients should have had greater difficulty resolving such competition. These results instead suggest that declining performance on our goal-driven categorisation task was linked to the use of a controlled retrieval strategy by healthy young adults. Patients may not have inhibited related non-target knowledge to facilitate initial categorisation like younger volunteers, and consequently they were less vulnerable to declining comprehension in this paradigm. Together, these results demonstrate circumstances which produce declines in continuous categorisation in healthy adults

Pathway-centric analysis of microbial metabolic potential and expression along nutrient and energy gradients in the western Atlantic Ocean

© The Author(s), 2022. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Cavaco, M. A., Bhatia, M. P., Hawley, A. K., Torres-Beltran, M., Johnson, W. M., Longnecker, K., Konwar, K., Kujawinski, E. B., & Hallam, S. J. Pathway-centric analysis of microbial metabolic potential and expression along nutrient and energy gradients in the western Atlantic Ocean. Frontiers in Marine Science, 9, (2022): 867310, https://doi.org/10.3389/fmars.2022.867310.Microbial communities play integral roles in driving nutrient and energy transformations in the ocean, collectively contributing to fundamental biogeochemical cycles. Although it is well known that these communities are stratified within the water column, there remains limited knowledge of how metabolic pathways are distributed and expressed. Here, we investigate pathway distribution and expression patterns from surface (5 m) to deep dark ocean (4000 m) at three stations along a 2765 km transect in the western South Atlantic Ocean. This study is based on new data, consisting of 43 samples for 16S rRNA gene sequencing, 20 samples for metagenomics and 19 samples for metatranscriptomics. Consistent with previous observations, we observed vertical zonation of microbial community structure largely partitioned between light and dark ocean waters. The metabolic pathways inferred from genomic sequence information and gene expression stratified with depth. For example, expression of photosynthetic pathways increased in sunlit waters. Conversely, expression of pathways related to carbon conversion processes, particularly those involving recalcitrant and organic carbon degradation pathways (i.e., oxidation of formaldehyde) increased in dark ocean waters. We also observed correlations between indicator taxa for specific depths with the selective expression of metabolic pathways. For example, SAR202, prevalent in deep waters, was strongly correlated with expression of the methanol oxidation pathway. From a biogeographic perspective, microbial communities along the transect encoded similar metabolic potential with some latitudinal stratification in gene expression. For example, at a station influenced by input from the Amazon River, expression of pathways related to oxidative stress was increased. Finally, when pairing distinct correlations between specific particulate metabolites (e.g., DMSP, AMP and MTA) and both the taxonomic microbial community and metatranscriptomic pathways across depth and space, we were able to observe how changes in the marine metabolite pool may be influenced by microbial function and vice versa. Taken together, these results indicate that marine microbial communities encode a core repertoire of widely distributed metabolic pathways that are differentially regulated along nutrient and energy gradients. Such pathway distribution patterns are consistent with robustness in microbial food webs and indicate a high degree of functional redundancy.This work was funded by the NSF Division of Ocean Sciences (Grant no. OCE-1154320 to EK and KL) and a small (“Microbial controls on marine organic carbon cycling”) and large (“Marine microbial communities from the Southern Atlantic Ocean transect to study dissolved organic matter and carbon cycling”) community sequencing grants from the Joint Genome Institute (US Department of Energy, Walnut Creek, CA) to SH and MB. MB was supported by an NSERC post-doctoral fellowship and a CIFAR Global Scholars fellowship. MC was supported by a Campus Alberta Innovates Program (CAIP) chair to MB