Urban fiscal austerity, infrastructure provision and the struggle for regional transit in 'Motor City'

Studies suggest that urban fiscal crises trigger the institutional separation of strategic services from general purpose municipal functions. Traditional reformists have highlighted the economic benefits of regional approaches. Global austerity has created fiscal problems for central cities and suburbs alike, transforming the motives for regional solutions. This paper examines how the City of Detroit engineered a new regional arrangement with the surrounding suburbs to raise debt for the delivery of mass transit infrastructure. It represents a dual 'spatial fix' in the form of (i) a 'state territorial fix' providing fiscally stressed municipalities access to municipal bond markets and (ii) a 'speculative spatial fix' that benefits the Detroit growth coalition by linking regional mass transit to the prospect of land-use intensification. © The Author 2014

Radiation environment and shielding for early manned Mars missions

The problem of shielding a crew during early manned Mars missions is discussed. Requirements for shielding are presented in the context of current astronaut exposure limits, natural ionizing radiation sources, and shielding inherent in a particular Mars vehicle configuration. An estimated range for shielding weight is presented based on the worst solar flare dose, mission duration, and inherent vehicle shielding

A Bayesian Approach to Graphical Record Linkage and De-duplication

We propose an unsupervised approach for linking records across arbitrarily many files, while simultaneously detecting duplicate records within files. Our key innovation involves the representation of the pattern of links between records as a bipartite graph, in which records are directly linked to latent true individuals, and only indirectly linked to other records. This flexible representation of the linkage structure naturally allows us to estimate the attributes of the unique observable people in the population, calculate transitive linkage probabilities across records (and represent this visually), and propagate the uncertainty of record linkage into later analyses. Our method makes it particularly easy to integrate record linkage with post-processing procedures such as logistic regression, capture-recapture, etc. Our linkage structure lends itself to an efficient, linear-time, hybrid Markov chain Monte Carlo algorithm, which overcomes many obstacles encountered by previously record linkage approaches, despite the high-dimensional parameter space. We illustrate our method using longitudinal data from the National Long Term Care Survey and with data from the Italian Survey on Household and Wealth, where we assess the accuracy of our method and show it to be better in terms of error rates and empirical scalability than other approaches in the literature.Comment: 39 pages, 8 figures, 8 tables. Longer version of arXiv:1403.0211, In press, Journal of the American Statistical Association: Theory and Methods (2015

Desynchronization of pathological low-frequency brain activity by the hypnotic drug zolpidem.

Reports of the beneficial effects of the hypnotic imidazopyridine, zolpidem, described in persistent vegetative state^1, 2^ have been replicated recently in brain-injured and cognitively impaired patients^3-7^. Previous single photon emission computed tomography (SPECT) studies have suggested that sub-sedative doses of zolpidem increased regional cerebral perfusion in affected areas^5, 8^, implying enhanced neuronal metabolic activity; which has led to speculation that zolpidem 'reawakens' functionally dormant cortex. However, a neuronal mechanism by which this hypnotic drug affords benefits to brain injured patients has yet to be demonstrated. Here, we report the action of sub-sedative doses of zolpidem on neuronal network oscillatory activity in human brain, measured using pharmaco-magnetoencephalography (pharmaco-MEG). Study participant JP suffered a stroke in 1996, causing major damage to the left hemisphere that impaired aspects of both motor and cognitive function. Pharmaco-MEG analyses revealed robust and persistent pathological theta (4-10Hz) and beta (15-30Hz) oscillations within the lesion penumbra and surrounding cortex. Administration of zolpidem (5mg) reduced the power of pathological theta and beta oscillations in all regions of the lesioned hemisphere. This desynchronizing effect correlated well with zolpidem uptake (occurring approximately 40 minutes after acute administration) and was coincident with marked improvements in cognitive and motor function. Control experiments revealed no effect of placebo, while a structurally unrelated hypnotic, zopiclone, administered at a comparable dose (3.5mg) elicited widespread increases in cortical oscillatory power in the beta (15-30Hz) band without functional improvement. These results suggest that in JP, specific motor and cognitive impairments are related to increased low-frequency oscillatory neuronal network activity. Zolpidem is unique amongst hypnotic drugs in its ability to desynchronize such pathological low-frequency activity, thereby restoring cognitive function

Using Bayesian Variable Selection Methods to Choose Style Factors in Global Stock Return Models

This paper applies Bayesian variable selection methods from the statistics literature to give guidance in the decision to include/omit factors in a global (linear factor) stock return model. Once one has accounted for country and sector, it is possible to see which style or styles best explains current asset returns. The study suggests that global style is not an important component once country and sector have been accounted for.

High-Field Functional Imaging of Pitch Processing in Auditory Cortex of the Cat.

The perception of pitch is a widely studied and hotly debated topic in human hearing. Many of these studies combine functional imaging techniques with stimuli designed to disambiguate the percept of pitch from frequency information present in the stimulus. While useful in identifying potential pitch centres in cortex, the existence of truly pitch-responsive neurons requires single neuron-level measures that can only be undertaken in animal models. While a number of animals have been shown to be sensitive to pitch, few studies have addressed the location of cortical generators of pitch percepts in non-human models. The current study uses high-field functional magnetic resonance imaging (fMRI) of the feline brain in an attempt to identify regions of cortex that show increased activity in response to pitch-evoking stimuli. Cats were presented with iterated rippled noise (IRN) stimuli, narrowband noise stimuli with the same spectral profile but no perceivable pitch, and a processed IRN stimulus in which phase components were randomized to preserve slowly changing modulations in the absence of pitch (IRNo). Pitch-related activity was not observed to occur in either primary auditory cortex (A1) or the anterior auditory field (AAF) which comprise the core auditory cortex in cats. Rather, cortical areas surrounding the posterior ectosylvian sulcus responded preferentially to the IRN stimulus when compared to narrowband noise, with group analyses revealing bilateral activity centred in the posterior auditory field (PAF). This study demonstrates that fMRI is useful for identifying pitch-related processing in cat cortex, and identifies cortical areas that warrant further investigation. Moreover, we have taken the first steps in identifying a useful animal model for the study of pitch perception

Early respiratory viral infections in infants with cystic fibrosis

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Background Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. Methods Infants with CF identified by newborn screening were enrolled prior to 4 months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5 months of life. Results Seventy infants were enrolled, mean age 3.1 ± 0.8 months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0–10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. Conclusions Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF

Choosing Management Information Systems as a Major: Understanding the smiFactors for MIS

Given declining management information systems (MIS) enrollments at our university, we seek to understand our students‘ selection of a major. Prior studies have found that students choose a major based on a number of factors, with subject matter interest consistently being most important. We contribute to the literature by developing a deeper understanding of what is meant by subject matter interest, which we refer to as smiFactors, for MIS as a major and career. Based on a qualitative analysis of open-ended survey questions completed by undergraduate business students, we confirm a number of smiFactors for MIS gleaned from recent studies and identify three new ones. We also relate our findings to broad categories of vocational interests. Of the newly identified smiFactors, one—linking business and technology—is unique to MIS, whereas the other two—practical application of course work and daily variety—apply to MIS as well as other majors and careers. Our findings provide a more complete foundation for helping students make an informed choice of MIS as a major. We use our findings and an extension of the Theory of Planned Behavior (TPB) to identify four types of intervention for increasing MIS enrollments