Prevalence and characteristics of spontaneous tinnitus in 11 year old children

Objective: To estimate the prevalence of spontaneous tinnitus in 11-year-old children. Design: A prospective UK population-based study. Study sample: A total of 7092 children from the Avon longitudinal study of parents and children (ALSPAC) who attended the hearing session at age 11 years and answered questions about tinnitus. Results: We estimated the prevalence of any spontaneous tinnitus as 28.1% (95% CI 27.1, 29.2%), and the prevalence of ‘clinically significant’ tinnitus as 3.1% (95% CI 2.7, 3.5%). Children were less likely to have clinically significant tinnitus if the tinnitus was ‘soft’ rather than ‘loud’ and if continuous rather than intermittent. Clinical significance was more likely if the tinnitus occurred more than once a week. Neither pitch nor length of history were important determinants of clinical significance. Small increases in mean hearing threshold (of up to 2.3 dB HL) were associated with clinically significant tinnitus. Conclusions: Although the prevalence of any tinnitus in 11-year-old children appears high, the small proportion in which this was found to be clinically significant implies that this does not necessarily indicate a large unmet clinical demand. We would expect approximately one child per class of 30 to have clinically significant tinnitus which is, by definition, problematic

NGC 4340: Double Bar + Fossil Nuclear Ring

NGC 4340 is a double-barred SB0 galaxy in the Virgo cluster (Wozniak et al. 1995). Here, we present evidence that this galaxy also posseses a luminous stellar nuclear ring of relatively old stars with little or no gas. The ring lies just outside the inner bar, at the probable inner inner Lindblad resonance (IILR) of the outer bar. Careful inspection of the isophotes and unsharp masks shows that the two bars are slightly misaligned, which suggests they may be independently rotating.Comment: 1 Page, 1 figure, kluwer.cls needed to complile (included in tar file) Poster presented at the Granada Euroconference (May, 2000): The Evolution of Galaxies. I- Observational clue

Association of SNPs in LCP1 and CTIF with hearing in 11 year old children:findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium

BACKGROUND: The genetic basis of hearing loss in humans is relatively poorly understood. In recent years, experimental approaches including laboratory studies of early onset hearing loss in inbred mouse strains, or proteomic analyses of hair cells or hair bundles, have suggested new candidate molecules involved in hearing function. However, the relevance of these genes/gene products to hearing function in humans remains unknown. We investigated whether single nucleotide polymorphisms (SNPs) in the human orthologues of genes of interest arising from the above-mentioned studies correlate with hearing function in children. METHODS: 577 SNPs from 13 genes were each analysed by linear regression against averaged high (3, 4 and 8 kHz) or low frequency (0.5, 1 and 2 kHz) audiometry data from 4970 children in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth-cohort at age eleven years. Genes found to contain SNPs with low p-values were then investigated in 3417 adults in the G-EAR study of hearing. RESULTS: Genotypic data were available in ALSPAC for a total of 577 SNPs from 13 genes of interest. Two SNPs approached sample-wide significance (pre-specified at p = 0.00014): rs12959910 in CBP80/20-dependent translation initiation factor (CTIF) for averaged high frequency hearing (p = 0.00079, β = 0.61 dB per minor allele); and rs10492452 in L-plastin (LCP1) for averaged low frequency hearing (p = 0.00056, β = 0.45 dB). For low frequencies, rs9567638 in LCP1 also enhanced hearing in females (p = 0.0011, β = -1.76 dB; males p = 0.23, β = 0.61 dB, likelihood-ratio test p = 0.006). SNPs in LCP1 and CTIF were then examined against low and high frequency hearing data for adults in G-EAR. Although the ALSPAC results were not replicated, a SNP in LCP1, rs17601960, is in strong LD with rs9967638, and was associated with enhanced low frequency hearing in adult females in G-EAR (p = 0.00084). CONCLUSIONS: There was evidence to suggest that multiple SNPs in CTIF may contribute a small detrimental effect to hearing, and that a sex-specific locus in LCP1 is protective of hearing. No individual SNPs reached sample-wide significance in both ALSPAC and G-EAR. This is the first report of a possible association between LCP1 and hearing function

Breast Cancer Fatalism: The Role of Women\u27s Perceptions of the Health Care System

Cancer fatalism, which can be understood as the belief that cancer is a death sentence, has been found to be a deterrent to preventive cancer screening participation. This study examines factors associated with breast cancer fatalism among women. We analyzed data from a 2003 survey of women 40 years of age. The survey collected information about respondents\u27 knowledge and attitudes regarding breast health. Analyses compared the characteristics of women who reported and those who did not report a fatalistic attitude. Women with a fatalistic attitude were more likely to be African American, to have a family history of breast cancer, to rate their quality of care as fair or poor, to believe that not much could be done to prevent breast cancer, to believe that breast cancer could not be cured if found early, and to believe that treatment could be worse than the disease

Full-field stimulus threshold testing:a scoping review of current practice

The full-field stimulus threshold (FST) is a psychophysical measure of whole-field retinal light sensitivity. It can assess residual visual function in patients with severe retinal disease and is increasingly being adopted as an endpoint in clinical trials. FST applications in routine ophthalmology clinics are also growing, but as yet there is no formalised standard guidance for measuring FST. This scoping review explored current variability in FST conduct and reporting, with an aim to inform further evidence synthesis and consensus guidance. A comprehensive electronic search and review of the literature was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR) checklist. Key source, participant, methodology and outcomes data from 85 included sources were qualitatively and quantitatively compared and summarised. Data from 85 sources highlight how the variability and insufficient reporting of FST methodology, including parameters such as units of flash luminance, colour, duration, test strategy and dark adaptation, can hinder comparison and interpretation of clinical significance across centres. The review also highlights an unmet need for paediatric-specific considerations for test optimisation. Further evidence synthesis, empirical research or structured panel consultation may be required to establish coherent standardised guidance on FST methodology and context or condition dependent modifications. Consistent reporting of core elements, most crucially the flash luminance equivalence to 0 dB reference level is a first step. The development of criteria for quality assurance, calibration and age-appropriate reference data generation may further strengthen rigour of measurement

A qualitative investigation of decision making during help-seeking for adult hearing loss

Objective: The Any Qualified Provider framework in the National Health Service has changed the way adult audiology services are offered in England. Under the new rules, patients are being offered a choice in geographical location and audiology provider. This study aimed to explore how choices in treatment are presented and to identify what information patients need when they are seeking help with hearing loss. Design: This study adopted qualitative methods of ethnographic observations and focus group interviews to identify information needed prior to, and during, help-seeking. Observational data and focus group data were analysed using the constant comparison method of grounded theory. Study sample: Participants were recruited from a community Health and Social Care Trust in the west of England. This service incorporates both an Audiology and a Hearing Therapy service. Twenty seven participants were involved in focus groups or interviews. Results: Participants receive little information beyond the detail of hearing aids. Participants report little information that was not directly related to uptake of hearing aids. Conclusions: Participant preferences were not explored and limited information resulted in decisions that were clinician-led. The gaps in information reflect previous data on clinician communication and highlight the need for consistent information on a range of interventions to manage hearing loss

PERSPECTIVES Development of interventions for language impairment: Why universal grammar may be harmful (Commentary on Ambridge, Pine, and Lieven)

Although theories of specific language impairment grounded in universal grammar (UG ) have advanced the description of SLI considerably, they provide limited utility as far as treatment is concerned. Because UG assumes deficits in language principles and parameter setting, remediation of the difficulty is not possible; rather, reliance on compensatory mechanisms is recommended. Compensatory mechanisms rely on the same learning principles as are adopted by theorists that adopt a more emergentist view. Thus, we agree with Ambridge, Pine, and Lieven that a UG-based approach is redundant and recommend focusing efforts on identifying and strengthening treatment strategies associated with general learning principles instead

Ecological Drought: Accounting for the Non-Human Impacts of Water Shortage in the Upper Missouri Headwaters Basin, Montana, USA

Water laws and drought plans are used to prioritize and allocate scarce water resources. Both have historically been human-centric, failing to account for non-human water needs. In this paper, we examine the development of instream flow legislation and the evolution of drought planning to highlight the growing concern for the non-human impacts of water scarcity. Utilizing a new framework for ecological drought, we analyzed five watershed-scale drought plans in southwestern Montana, USA to understand if, and how, the ecological impacts of drought are currently being assessed. We found that while these plans do account for some ecological impacts, it is primarily through the narrow lens of impacts to fish as measured by water temperature and streamflow. The latter is typically based on the same ecological principles used to determine instream flow requirements. We also found that other resource plans in the same watersheds (e.g., Watershed Restoration Plans, Bureau of Land Management (BLM) Watershed Assessments or United States Forest Service (USFS) Forest Plans) identify a broader range of ecological drought risks. Given limited resources and the potential for mutual benefits and synergies, we suggest greater integration between various planning processes could result in a more holistic consideration of water needs and uses across the landscape