Концепції мовної гри як теоретичні засади організації навчально-ігрової діяльності

У статті розглянуто лінгвофілософські й лінгвістичні концепції мовної гри як підґрунтя організації навчально-ігрової діяльності в системі українськомовної освіти. На основі наукового осмислення окреслено зміст понять "гра", "навчально-ігрова діяльність", "мовна гра". Шляхом аналізу наукової літератури й синтезу теоретичних ідей визначено принципи побудови й реалізації навчально-методичної системи, спрямованої на формування мовної особистості школяра в навчально-ігровій діяльності

Fingolimod Alters Tissue Distribution and Cytokine Production of Human and Murine Innate Lymphoid Cells

Sphingosine-1 phosphate receptor 1 (S1PR1) is expressed by lymphocytes and regulates their egress from secondary lymphoid organs. Innate lymphoid cell (ILC) family has been expanded with the discovery of group 1, 2 and 3 ILCs, namely ILC1, ILC2 and ILC3. ILC3 and ILC1 have remarkable similarity to CD4+ helper T cell lineage members Th17 and Th1, respectively, which are important in the pathology of multiple sclerosis (MS). Whether human ILC subsets express S1PR1 or respond to its ligands have not been studied. In this study, we used peripheral blood/cord blood and tonsil lymphocytes as a source of human ILCs. We show that human ILCs express S1PR1 mRNA and protein and migrate toward S1P receptor ligands. Comparison of peripheral blood ILC numbers between fingolimod-receiving and treatment-free MS patients revealed that, in vivo, ILCs respond to fingolimod, an S1PR1 agonist, resulting in ILC-penia in circulation. Similarly, murine ILCs responded to fingolimod by exiting blood and accumulating in the secondary lymph nodes. Importantly, ex vivo exposure of ILC3 and ILC1 to fingolimod or SEW2871, another S1PR1 antagonist, reduced production of ILC3- and ILC1- associated cytokines GM-CSF, IL-22, IL-17, and IFN-γ, respectively. Surprisingly, despite reduced number of lamina propria-resident ILC3s in the long-term fingolimod-treated mice, ILC3-associated IL-22, IL-17A, GM-CSF and antimicrobial peptides were high in the gut compared to controls, suggesting that its long term use may not compromise mucosal barrier function. To our knowledge, this is the first study to investigate the impact of fingolimod on human ILC subsets in vivo and ex vivo, and provides insight into the impact of long term fingolimod use on ILC populations

Towards versatile access networks (Chapter 3)

Compared to its previous generations, the 5th generation (5G) cellular network features an additional type of densification, i.e., a large number of active antennas per access point (AP) can be deployed. This technique is known as massive multipleinput multiple-output (mMIMO) [1]. Meanwhile, multiple-input multiple-output (MIMO) evolution, e.g., in channel state information (CSI) enhancement, and also on the study of a larger number of orthogonal demodulation reference signal (DMRS) ports for MU-MIMO, was one of the Release 18 of 3rd generation partnership project (3GPP Rel-18) work item. This release (3GPP Rel-18) package approval, in the fourth quarter of 2021, marked the start of the 5G Advanced evolution in 3GPP. The other items in 3GPP Rel-18 are to study and add functionality in the areas of network energy savings, coverage, mobility support, multicast broadcast services, and positionin

Architecture landscape

The network architecture evolution journey will carry on in the years ahead, driving a large scale adoption of 5th Generation (5G) and 5G-Advanced use cases with significantly decreased deployment and operational costs, and enabling new and innovative use-case-driven solutions towards 6th Generation (6G) with higher economic and societal values. The goal of this chapter, thus, is to present the envisioned societal impact, use cases and the End-to-End (E2E) 6G architecture. The E2E 6G architecture includes summarization of the various technical enablers as well as the system and functional views of the architecture

Energy efficient radio resource management in a coordinated multi-cell distributed antenna system

As well as the demand for higher data rates goes on, the rising energy costs and environmental concerns have also led researchers to increase energy efficiency in terms of bits-per-Joule. Cooperative communications with low power nodes, switching off under-utilized cells due to low traffic load and energy efficient radio resource management are some of the energy saving methods. It is observed that the conventional energy efficiency expression, which is defined as the ratio of the data rate to the total transmission power, can limit the system throughput significantly. In this paper, we introduce a novel energy efficiency expression which provides a trade-off between sum-rate maximization and total transmission power minimization in the network. A coordinated multi-cell distribut

Functional Outcomes and Long-term Durability of Artificial Urinary Sphincter Application: Review of 56 Patients With Long-term Follow-up

Purpose: To evaluate the long-term outcomes of artificial urinary sphincter (AUS) implantation and to report the complication rates, including mechanical failure, erosion, and infection. Materials and Methods: From June 1990 to May 2011, AUS (AMS 800) implantations were performed in 56 adult males by one surgeon. Various demographic and preoperative variables, surgical variables, and postoperative outcomes, including success and complication rates with a median follow-up of 96 months, were recorded retrospectively. Results: The mean age of the patients at the time of AUS implantation was 61.8 (+/- 14.2) years. During the follow-up period, the total complication rate was 41.1% ( 23 patients). The incidence of complications was significantly lower during the follow-up period after 48 months ( p< 0.05). Kaplan-Meier analysis revealed that 5-and 10-failure-free rates were 50.3% and 45.2%, respectively. Conclusions: Long-term durability and functional outcomes are achievable for the AMS 800, but there are appreciable complication rates for erosion, mechanical failure, and infection of up to 30%

Alterations in Body Uneasiness, Eating Attitudes, and Psychopathology Before and After Cross-Sex Hormonal Treatment in Patients with Female-to-Male Gender Dysphoria

Body dissatisfaction plays an important role in the development of psychiatric problems such as eating disorders as well as gender dysphoria (GD). Cross-sex hormonal treatment (CHT) alleviates the dissatisfaction by making various changes in the body. We examined the alteration of body uneasiness, eating attitudes and behaviors, and psychological symptoms longitudinally in Turkish participants with female-to-male gender dysphoria (FtM GD) after CHT. Thirty-seven participants with FtM GD and 40 female controls were asked to complete the Body Uneasiness Test to explore different areas of body-related psychopathology, the Eating Attitudes Test to assess eating disturbances, and the Symptom Checklist-90 Revised to measure psychological state, both before CHT and after 6months of CHT administration. The baseline mean body weight, BMI scores, body uneasiness scores, and general psychopathological symptoms of participants with FtM GD were significantly higher than female controls, whereas baseline eating attitudes and behaviors were not significantly different. Over time, FtM GD participants' mean body weight and BMI scores increased, body uneasiness and general psychopathological symptoms decreased, and eating attitudes and behaviors had not changed at 24th weeks following CHT administration compared to baseline. CHT may have a positive impact on body uneasiness and general psychopathological symptoms in participants with FtM GD. However, CHT does not have an impact on eating attitudes and behaviors

Burden of Chronic Low Back Pain in the Turkish Population

WOS: 000353480500011Objective: Chronic low back pain (CLBP) is a great economic burden to the society mainly in terms of the large number of the lost work days and disability, and it appears to be growing. The economic burden of LBP in Turkey is not known. This study aims to analyze the health care resource use, work and productivity loss, and health-related economics of CLBP in Turkey. Material and Methods: The study was designed as a multi-centered cross-sectional survey of patients in physical therapy and rehabilitation clinics from eight different regions of Turkey and 662 patients with CLBP over 18 years of age were included. Data on patient sociodemographics, disease-related healthcare resource use during the previous 6 months, inability to work during the last 3 months, Roland Morris Disability Index for the functional status, and psychological health with Beck Depression Scale were collected. Direct costs included medical visits, investigations, medications, hospitalizations, orthopedic aids, and physical therapy. Indirect costs were evaluated mostly with productivity loss. Results: The total annual direct costs for CLBP per patient were estimated at 1080 TL. The indirect costs were estimated at 5511 TL per patient. Direct cost was correlated with disease severity, duration, and age. Indirect cost was higher in women. Conclusion: The indirect costs for CLBP were significantly higher than the direct costs

Distributed MIMO Systems for 6G

This study focuses on Distributed MIMO (D-MIMO) systems and provides a discussion about their role in next generation networks. The paradigm shift to distributed networks offers great potential to address the 6G requirements, through macro diversity. As 6G scenarios and use cases continue to emerge, new challenges are likely to arise that may affect the widespread imp-lementation of D-MIMO. To address those, different deployment options have been proposed for roll-out considerations. They are composed of several sub-components that can be categorized as (i) wireless or wired fronthaul/backhaul, (ii) analog or digital signals, (iii) distributed or centralized processing, and (iv) coherent or non-coherent transmission. To facilitate standardization efforts, we provide 3GPP-aligned terminology for network nodes, multi-point transmission and reception schemes. In order to enable large-scale implementation of D-MIMO systems, it is important to determine the needed amount of distribution, develop practical solutions for high-frequency bands, and ways to convey data that meet the transport requirements. On this regard, we discuss key enablers and present simulation results for D-MIMO systems towards 6G. In particular, we present solutions for D-MIMO networks in dynamic scenarios related to channel estimation and layer-l mobility considering coherent and non-coherent joint transmission, and analog fronthaul implementation using analog-radio-over-fiber that are promising for high (upper mm-Wave and (sub-)THz) carrier frequencies, as well as integrated access and backhaul, network-controlled repeaters, and reconfigurable intelligent surfaces that are possible enablers for cost-efficient network densification at both low (cm-Wave, lower mm-Wave) and high carrier frequencies

A Short Survey of Hyperspectral Remote Sensing and Hyperspectral Remote Sensing Research At TUBITAK UZAY

Hyperspectral remote sensing (HSRS) is becoming more and more attractive. Recent advances in sensor technologies enabled numerous applications of this imaging modality. HSRS research has been conducted at TUBITAK UZAY since 2012. This paper provides a short survey of these research and development activities ranging from hyperspectral remote sensing applications, radiometric correction, geometric correction and denoising to classification and fusion with other modalities of HS data using most recent algorithms