Generation Rx Initiative

IMPACT. 1: Partnering with the Cardinal Health Foundation, the program has created educational resources aimed at specific populations that are available to the public for free. These kits provide presentations, handouts, activities, and other related materials. -- 2. Its original community-based toolkit has been used in every state in the country. Toolkits have also been developed for youth, teens, college students, and seniors. Nearly half of the 127 Schools of Pharmacy in the U.S. now have an active Generation Rx Program.OSU PARTNERS: College of Pharmacy; College of Social Work; Counseling and Consultation; Services; OSU Extension; Office of Student WellnessCOMMUNITY PARTNERS: Cardinal Health Foundation; Drug Free Action Alliance; National Council on Patient Information and Education; Ohio Department of Health; Ohio Department of Alcohol and Drug Addiction Services; American Pharmacists Association; - Academy of Student Pharmacists; (APhA-ASP); The BACCHUS Network; InterACT; NOPE Task Force; Ohio Pharmacists Association; WOSU@COSI; Other colleges and universitiesPRIMARY CONTACT: Kenneth M. Hale ([email protected]); Nicole Cartwright Kwiek ([email protected])Unintentional drug poisoning is now the leading cause of accidental death in the country. On average, four people in Ohio and 100 across the U.S. die from these drug overdoses each day. The Generation Rx Initiative was created by the College of Pharmacy in 2007 to address this serious public health problem

Generation Rx Initiative

IMPACT. 1: Partnering with the Cardinal Health Foundation, the program has created educational resources aimed at specific populations that are available to the public for free. These toolkits provide presentations, handouts, activities, and other related materials. -- 2. The original community-based toolkit has been used in every state in the country. Additional toolkits have also been developed for youth, teens, college students, and seniors. A new elementary toolkit entitled "Medication Safety Patrol" debuted in the spring of 2014.OSU PARTNERS: College of Pharmacy; College of Social Work; Counseling and Consultation Services; OSU Extension; Office of Student WellnessCOMMUNITY PARTNERS: Cardinal Health Foundation; Drug Free Action Alliance; National Council on Patient Information and Education; Ohio Department of Health; Ohio Department of Alcohol and Drug Addiction Services; American Pharmacists Association - Academy of Student Pharmacists (APhA-ASP); The BACCHUS Network; InterACT; NOPE Task Force; Ohio Pharmacists Association; WOSU@COSI; Other colleges and universitiesPRIMARY CONTACT: Kenneth M. Hale ([email protected]); Nicole Cartwright Kwiek ([email protected])Unintentional drug poisoning is now the leading cause of accidental death in the country. On average, five people in Ohio and 100 across the U.S. die from these drug overdoses each day. The Generation Rx Initiative was created by the College of Pharmacy in 2007 to address this serious public health problem of prescription drug misuse and abuse

Quantum Monte Carlo calculations of neutron-alpha scattering

We describe a new method to treat low-energy scattering problems in few-nucleon systems, and we apply it to the five-body case of neutron-alpha scattering. The method allows precise calculations of low-lying resonances and their widths. We find that a good three-nucleon interaction is crucial to obtain an accurate description of neutron-alpha scattering.Comment: 4 pages, 2 figures, submitted to Physical Review Letter

The Essential Amino Acid Content of Cottonseed, Peanut and Soybean Products.

12 p

Methods for reproductive tract scoring as a tool for improving sow productivity

Improving sow lifetime productivity (SLP) is essential for maximizing farm profitability. Study objectives were to determine the accuracy for different vulva scoring methods in a commercial production system and to assess whether gilt reproductive tract scoring (evaluated by vulva width; VW) prior to puberty could serve as useful gilt selection criteria. To accomplish this objective, 958 prepubertal replacement gilts in a commercial system were evaluated at approximately 15 weeks of age. Gilt body weight was recorded in addition to four different methods to evaluate VW. Methods for VW assessment included digital caliper measurement (mm), visual evaluation and scoring by trained farm personnel (Farm Score; FS), and two methods using scoring tools (Vulva Score Method A and B; VSA and VSB, respectively) specifically calibrated from the VW distribution measured on gilts from previous studies. The VSA and FS methods assigned gilts to one of three categories (S, M, L and 1, 2, 3, respectively) whereas VSB classified gilts vulvas using a five-point scoring system (1 to 5). At 15-wk of age, a low proportion of variability in vulva size (27.8 ± 0.1 mm) could be explained by BW (62.2 ± 0.2 kg; R2 = 0.05). All three scoring methods were effective in categorizing gilts based upon VW, as the measured VW size within methods differed by score (P \u3c 0.01). The proportion of gilts achieving their first parity increased with score for VSA (64.7, 73.2, and 84.4%; P = 0.02), VSB (66.0, 71.7, 79.2, 76.4, and 84.2%; P = 0.02), and FS (67.2, 75.0, and 88.8%; P = 0.03), but VSA, VSB, and FS did not influence percentage of gilts achieving their second parity (P = 0.32, 0.29, and 0.30, respectively). Litter performance of gilts scored as M or L using VSA improved with an increased total born over two parities compared to those scored as S (23.96 vs. 26.38 pigs; P \u3c 0.01) as well as born alive (21.13 vs. 23.05 pigs; P \u3c 0.05). Results were similar for VSB, where scores 2-5 had greater total born (23.97 vs. 26.33 pigs; P \u3c 0.01) and born alive (21.11 vs. 23.02 pigs; P \u3c 0.05) through two parities compared to gilts scored 1. Using the FS method, total born pigs tended to be increased (P = 0.06) through two parities for gilts having a 2 or 3 vulva score compared to those scored as a 1. Collectively, assessing VW at approximately 15 wk of age may identify sows with improved productivity through two parities as breeding herd females

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

ABSTRACT While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS-CoV) accessory ORFs (deletion of ORF3, -4a, -4b, and -5 [dORF3-5]) has major implications for viral replication and pathogenesis. Importantly, attenuation of the dORF3-5 mutant is primarily driven by dysregulated host responses, including disrupted cell processes, augmented interferon (IFN) pathway activation, and robust inflammation. In vitro replication attenuation also extends to in vivo models, allowing use of dORF3-5 as a live attenuated vaccine platform. Finally, examination of ORF5 implicates a partial role in modulation of NF-κB-mediated inflammation. Together, the results demonstrate the importance of MERS-CoV accessory ORFs for pathogenesis and highlight them as potential targets for surveillance and therapeutic treatments moving forward. IMPORTANCE The initial emergence and periodic outbreaks of MERS-CoV highlight a continuing threat posed by zoonotic pathogens to global public health. In these studies, mutant virus generation demonstrates the necessity of accessory ORFs in regard to MERS-CoV infection and pathogenesis. With this in mind, accessory ORF functions can be targeted for both therapeutic and vaccine treatments in response to MERS-CoV and related group 2C coronaviruses. In addition, disruption of accessory ORFs in parallel may offer a rapid response platform to attenuation of future emergent strains based on both SARS- and MERS-CoV accessory ORF mutants

1962: Abilene Christian College Bible Lectures - Full Text

THE RESTORATION PRINCIPLE” Being the Abilene Christian College Annual Bible Lectures 1962 Price: $3.95 Published by ABILENE CHRISTIAN COLLEGE STUDENTS EXCHANGE ACC Station Abilene, Texa

The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development

Type I diabetes is caused by loss of insulin-secreting beta cells. To identify novel, pharmacologically-targetable histone-modifying proteins that enhance beta cell production from pancreatic progenitors, we performed a screen for histone modifications induced by signal transduction pathways at key pancreatic genes. The screen led us to investigate the temporal dynamics of ser-28 phosphorylated histone H3 (H3S28ph) and its upstream kinases, MSK1 and MSK2 (MSK1/2). H3S28ph and MSK1/2 were enriched at the key endocrine and acinar promoters in E12.5 multipotent pancreatic progenitors. Pharmacological inhibition of MSK1/2 in embryonic pancreatic explants promoted the specification of endocrine fates, including the beta-cell lineage, while depleting acinar fates. Germline knockout of both Msk isoforms caused enhancement of alpha cells and a reduction in acinar differentiation, while monoallelic loss of Msk1 promoted beta cell mass. Our screen of chromatin state dynamics can be applied to other developmental contexts to reveal new pathways and approaches to modulate cell fates

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin