569 research outputs found

    Discussions on the Environmental Strategies of SMEs

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    Environmental issues have become the focal point of society. However, China enterprises have not paid enough attention to environmental issues, especially those of SMEs. In this paper, it points out that environmental issues of SMEs are imperative. By analyzing the restrictive factors, we puts forward four environment strategies based on internal capability and the pollution degree of the enterprises and analyze each strategy in details

    An Empirical Research on the Impact of E-commerce Enterprise Reputation on Online Consumer Behavior: A Case Study of B2C Websites

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    As a means of non-price competition, the reputation of enterprises is valued by e-commerce enterprises. From the perspective of consumers, this paper divides corporate reputation into five elements. Corporate reputation will affect consumer behavior. Based on the trust to the enterprise, consumers show satisfaction to the products and services of the enterprise and customer loyalty behavior. Therefore, the paper constructs a theoretical analysis model, and uses data analysis and data processing to verify the relationship between e-commerce enterprise reputation and consumer behavior, and then puts forward relevant suggestions

    State Estimation for Discrete-Time Fuzzy Cellular Neural Networks with Mixed Time Delays

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    This paper is concerned with the exponential state estimation problem for a class of discrete-time fuzzy cellular neural networks with mixed time delays. The main purpose is to estimate the neuron states through available output measurements such that the dynamics of the estimation error is globally exponentially stable. By constructing a novel Lyapunov-Krasovskii functional which contains a triple summation term, some sufficient conditions are derived to guarantee the existence of the state estimator. The linear matrix inequality approach is employed for the first time to deal with the fuzzy cellular neural networks in the discrete-time case. Compared with the present conditions in the form of M-matrix, the results obtained in this paper are less conservative and can be checked readily by the MATLAB toolbox. Finally, some numerical examples are given to demonstrate the effectiveness of the proposed results

    Development and Validation of a Predictive Model for the Prognosis of Complications of Supracondylar Fractures of The Humerus in Children

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    Objective: Informing patient consultations and healthcare choices, clinical predictive models can offer patients tailored projections of the outcome. The most frequent elbow fractures in children are supracondylar humerus fractures, and clinical prediction models were still largely underutilized in these cases. By developing and verifying a prediction model to lower the risk of postoperative problems in children with supracondylar humerus fractures, this research sought to evaluate independent risk variables connected with the incidence of complications of supracondylar humerus fractures in children. Methods: We retrospectively studied 411 children with supracondylar humerus fractures treated surgically at our hospital from 2015 to 2019, and explored the independent risk factors affecting the prognosis of supracondylar humerus fractures in children in the study group using univariate and multifactorial Cox regression analysis, respectively. In addition, a prediction model based on the independent factors was constructed, a nomogram was made and data from the two cohorts were used to verify the feasibility and reliability of the model and visualize the data. Results: Height, older than eight years, weight, nerve damage, fracture type and with joystick technology of the child as independent risk factors influenced the prognosis of pediatric supracondylar humerus fractures in the modeling constructed by the training cohort, respectively. The results of the validation cohort were further screened for older than eight years, nerve injury and fracture type as independent prognostic factors. Conclusions: We were able to construct a predictive model based on a large genuine data sample, and clinical characteristics in this model could be used as independent predictors for reducing the occurrence of postoperative complications in supracondylar fractures. Combining basic vital signs and clinical risk factors into a simple and clear nomogram was more likely to result in the best treatment plan

    Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice

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    The prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically increased globally during recent decades. Intake of n-3 polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3), is believed to be beneficial to the development of NAFLD. However, little information is available with regard to the effect of flaxseed oil rich in α-linolenic acid (ALA, C18:3n-3), a plant-derived n-3 PUFA, in improving NAFLD. This study was to gain the effect of flaxseed oil on NAFLD and further investigate the underlying mechanisms. Apolipoprotein-E knockout (apoE-KO) mice were given a normal chow diet, a western-type high-fat and high-cholesterol diet (WTD), or a WTD diet containing 10% flaxseed oil (WTD + FO) for 12 weeks. Our data showed that consumption of flaxseed oil significantly improved WTD-induced NAFLD, as well as ameliorated impaired lipid homeostasis, attenuated oxidative stress, and inhibited inflammation. These data were associated with the modification effects on expression levels of genes involved in de novo fat synthesis (SREBP-1c, ACC), triacylglycerol catabolism (PPARα, CPT1A, and ACOX1), inflammation (NF-κB, IL-6, TNF-α, and MCP-1), and oxidative stress (ROS, MDA, GSH, and SOD)

    Linking Biochemical Pathways and Networks to Adverse Drug Reactions

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    Sequence Analysis of Alginate-Derived Oligosaccharides by Negative-Ion Electrospray Tandem Mass Spectrometry

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    Negative-ion electrospray tandem mass spectrometry (ES-MS/MS) with collision-induced dissociation (CID) is attempted for sequence determination of alginate oligosaccharides, derived from polyanionic alginic acid, polymannuronate, and polyguluronate by partial depolymerization using either alginate lyase or mild acid hydrolysis. Sixteen homo- and hetero-oligomeric fragments were obtained after fractionation by gel-filtration and strong anion exchange high performance liquid chromatography. The product-ion spectra of these alginate oligosaccharides were dominated by intense B-, C-, Y-, and Z-type ions together with 0,2A- and 2,5A-ions of lower intensities. Internal mannuronate residues (M) produce weak but specific decarboxylated Zint-ions (Zint − 44 Da; int: denotes internal), which can be used for distinction of M and a guluronate residue (G) at an internal position. A reducing terminal M or G, although neither gives rise to a specific ion, can be identified by differences in the intensity ratio of fragment ions of the reducing terminal residue [2,5Ared]/[0,4Ared] (red: denotes reducing terminal)
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