Efficacy and safety of combined use of docetaxelgemcitabine chemotherapy and 5-fluorouracil targeted therapy in the treatment of advanced non-small cell lung cancer

Purpose: To determine the efficacy of combined use of docetaxel-gemcitabine chemotherapy and 5- fluorouracil (5-FU) targeted therapy for the treatment of advanced non-small cell lung cancer (NSCLC). Methods: Eighty advanced NSCLC patients in Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University) (March 2020 - March 2021) were selected and randomly assigned to chemo group (CHEG) and combination group (COMG), with 40 patients per group. All patients received docetaxel-gemcitabine chemotherapy. On the 1st, 8th and 15th day of treatment, docetaxel (20 mg/m2) was injected via intravenous drip. On the 2nd, 9th and 16th day, gemcitabine hydrochloride (1 g/m2) was injected, also via intravenous drip. The dose regimens were repeated once every 28 days. In addition, patients in COMG received 5-FU targeted therapy at a dose of 15 mg/kg body weight, in 5 % glucose solution, via intravenous drip for 5 - 8 h daily for 5 consecutive days. Thereafter, the dose was reduced by half and the drug injected once every other day. Therapeutic efficacy as well as various clinical and biochemical indices were assessed in both groups. Results: Compared with CHEG, COMG had a slightly higher objective remission rate and a higher disease control rate (p < 0.05). After treatment, there was decrease in levels of serum carcinoembryonic antigen (CEA), squamous cell carcinoma (SCC) and cytokeratin 19 fragment antigen 21-1 (CY-FRA21- 1), with lower levels in COMG than in CHEG (p < 0.05). The median survival time was shorter in CHEG than in COMG (p < 0.05). However, no notable differences in the incidence of adverse reactions were observed between the two groups (p > 0.05). Conclusion: Combined use of docetaxel-gemcitabine chemotherapy and 5-FU-targeted therapy downregulates the expressions of serum CEA, SCC and CY-FRA21-1 tumor markers, but significantly prolongs overall survival of patients. Therefore, this therapeutic strategy is safe but should be subjected to further clinical trials prior to application in clinical practice. Keywords: 5-Fluorouracil (5-FU; Advanced non-small cell lung cancer (NSCLC); docetaxel; Gemcitabin

Narrow-line-width UV bursts in the transition region above Sunspots observed by IRIS

Various small-scale structures abound in the solar atmosphere above active regions, playing an important role in the dynamics and evolution therein. We report on a new class of small-scale transition region structures in active regions, characterized by strong emissions but extremely narrow Si IV line profiles as found in observations taken with the Interface Region Imaging Spectrograph (IRIS). Tentatively named as Narrow-line-width UV bursts (NUBs), these structures are located above sunspots and comprise of one or multiple compact bright cores at sub-arcsecond scales. We found six NUBs in two datasets (a raster and a sit-and-stare dataset). Among these, four events are short-living with a duration of $\sim$10 mins while two last for more than 36 mins. All NUBs have Doppler shifts of 15--18 km/s, while the NUB found in sit-and-stare data possesses an additional component at $\sim$50 km/s found only in the C II and Mg II lines. Given that these events are found to play a role in the local dynamics, it is important to further investigate the physical mechanisms that generate these phenomena and their role in the mass transport in sunspots.Comment: 8 pages, 4 figures and 1 table, accepted for publication in ApJ

Parallel-cascade-based mechanisms for heating solar coronal loops: test against observations

The heating of solar coronal loops is at the center of the problem of coronal heating. Given that the origin of the fast solar wind has been tracked down to atmospheric layers with transition region or even chromospheric temperatures, it is worthy attempting to address whether the mechanisms proposed to provide the basal heating of the solar wind apply to coronal loops as well. We extend the loop studies based on a classical parallel-cascade scenario originally proposed in the solar wind context by considering the effects of loop expansion, and perform a parametric study to directly contrast the computed loop densities and electron temperatures with those measured by TRACE and YOHKOH/SXT. This comparison yields that with the wave amplitudes observationally constrained by SUMER measurements, while the computed loops may account for a significant fraction of SXT loops, they seem too hot when compared with TRACE loops. Lowering the wave amplitudes does not solve this discrepancy, introducing magnetic twist will make the comparison even less desirable. We conclude that the nanoflare heating scenario better explains ultraviolet loops, while turbulence-based steady heating mechanisms may be at work in heating a fraction of soft X-ray loops.Comment: 6 pages, 1 figure, to appear in proceedings of AstroNum-201

Plasma parameters and geometry of cool and warm active region loops

How the solar corona is heated to high temperatures remains an unsolved mystery in solar physics. In the present study we analyse observations of 50 whole active-region loops taken with the Extreme-ultraviolet Imaging Spectrometer (EIS) on board the Hinode satellite. Eleven loops were classified as cool (<1 MK) and 39 as warm (1-2 MK) loops. We study their plasma parameters such as densities, temperatures, filling factors, non-thermal velocities and Doppler velocities. We combine spectroscopic analysis with linear force-free magnetic-field extrapolation to derive the three-dimensional structure and positioning of the loops, their lengths and heights as well as the magnetic field strength along the loops. We use density-sensitive line pairs from Fe XII, Fe XIII, Si X and Mg VII ions to obtain electron densities by taking special care of intensity background-subtraction. The emission-measure loci method is used to obtain the loop temperatures. We find that the loops are nearly isothermal along the line-of-sight. Their filling factors are between 8% and 89%. We also compare the observed parameters with the theoretical RTV scaling law. We find that most of the loops are in an overpressure state relative to the RTV predictions. In a followup study, we will report a heating model of a parallel-cascade-based mechanism and will compare the model parameters with the loop plasma and structural parameters derived here.Comment: ApJ, accepted for publicatio

Eruptions from coronal bright points : a spectroscopic view by IRIS of a mini-filament eruption, QSL reconnection, and reconnection-driven outflows

Funding: The authors thank very much the referee for the very important comments and suggestions. MM and TW acknowledge DFG-grant WI3211/8-1. D.H.M. would like to acknowledge STFC for support via the Consolidated Grant SMC1/YST037. Open Access funding provided by the Max Planck Society.Context. Our study investigates a mini-filament eruption associated with cancelling magnetic fluxes. The eruption originates from a small-scale loop complex commonly known as a coronal bright point (CBP). The event is uniquely recorded in both the imaging and spectroscopic data taken with the Interface Region Imaging Spectrograph (IRIS). Aims. The investigation aims to gain a better understanding of the physical processes driving these ubiquitous small-scale eruptions. Methods. We analysed IRIS spectroscopic and slit-jaw imaging observations as well as images taken in the extreme-ultraviolet channels of the Atmospheric Imaging Assembly (AIA) and line-of-sight magnetic-field data from the Helioseismic Magnetic Imager (HMI) on board the Solar Dynamics Observatory. As the observations can only indicate the possible physical processes at play, we also employed a non-linear force-free field (NLFFF) relaxation approach based on the HMI magnetogram time series. This allowed us to further investigate the evolution of the magnetic-field structures involved in the eruption process. Results. We identified a strong small-scale brightening as a micro-flare in a CBP, recorded in emission from chromospheric to flaring plasmas. The mini-eruption is manifested via the ejection of hot (CBP loops) and cool (mini-filament) plasma recorded in both the imaging and spectroscopic data. The micro-flare is preceded by the appearance of an elongated bright feature in the IRIS slit-jaw 1400 Å images, located above the polarity inversion line. The micro-flare starts with an IRIS pixel size brightening and propagates bi-directionally along the elongated feature. We detected, in both the spectral and imaging IRIS data and AIA data, strong flows along and at the edges of the elongated feature; we believe that these represent reconnection outflows. Both edges of the elongated feature that wrap around the edges of the erupting MF evolve into a J-type shape, creating a sigmoid appearance. A quasi-separatrix layer (QSL) is identified in the vicinity of the polarity inversion line by computing the squashing factor, Q, in different horizontal planes of the NLFFF model.  Conclusions. This CBP spectro-imaging study provides further evidence that CBPs represent downscaled active regions and, as such, they may make a significant contribution to the mass and energy balance of the solar atmosphere. They are the sources of all range of typical active-region features, including magnetic reconnection along QSLs, (mini-)filament eruptions, (micro-)flaring, reconnection outflows, etc. The QSL reconnection site has the same spectral appearance as the so-called explosive events identified by strong blue- and red-shifted emission, thus providing an answer to an outstanding question regarding the true nature of this spectral phenomenon.Publisher PDFPeer reviewe

The Prevalence of and Factors Associated With Anxiety and Depression Among Working-Age Adults in Mainland China at the Early Remission Stage of the Coronavirus 2019 Pandemic

Background: The Coronavirus 2019 (COVID-19) outbreak has led to a considerable proportion of adverse psychological symptoms in different subpopulations. This study aimed to investigate the status of anxiety and depression and their associated factors in the adult, working-age population in Mainland China at the early remission stage of the COVID-19 pandemic. Methods: An online study was conducted among 1,863 participants in 29 provinces in Mainland China from March 23 to 31, 2020. Their mental health was evaluated by the generalized anxiety disorder scale (GAD-7) and the patient health questionnaire (PHQ-9). Descriptive analysis, Chi-square, and multiple logistic regressions were applied. Results: About 44.5% of the participants had anxiety, 49.2% had depression, and 37.9% showed a combination of depression and anxiety. Around 83.7% of the participants claimed that the pandemic had a negative impact on their medical needs, which was the primary predictor of mental health, the degree of impact being positively related to the prevalence of anxiety and depression. More chronic diseases, moderate to bad self-rated health, severe perceived infection risk, and younger age group were the common risk factors for anxiety and depression. Having no children, unemployment, and a college-level educational background were associated with higher anxiety prevalence, whereas unmarried participants were correlated with higher depression prevalence. Conclusion: The working-age population showed a relatively high risk of anxiety and depression in Mainland China at the early remission stage of the pandemic. To improve medical services capacity for routine and delayed medical service needs should be a part of policy-makers\u27 priority agenda during this period of crisis

Quality of Life of Adults with Chronic Spinal Cord Injury in Mainland China: A Cross-Sectional Study

Objective: To evaluate the quality of life of patients with chronic spinal cord injury in mainland China. Design: Cross-sectional study. Subjects: A total of 247 adults ≥ 1 year post-SCI in mainland China. Methods: The World Health Organization (WHO) Quality of Life Scale Brief Version (WHOQOL-BREF) and the add-on modules on disability-related QoL (WHOQOL-DIS) were used to assess quality of life. Anxiety/depression was measured using the Zung Self-Rating Anxiety/Depression Scale. Quality of life was compared with that of reference populations from China, Korea, the international field trial (23 countries). Multivariate linear regression was conducted to determine the factors that might be associated with quality of life. Results: The means of the 4 domains of the WHOQOLBREF varied from 11.5 to 13.0. The mean of the 12- item WHOQOL-DIS module was 38.7. The quality of life of the participants as measured by the WHOQOLBREF was 1.1--4.7 points lower than that of the global reference population, while quality of life as measured by the WHOQOL-DIS module was 1.2 points lower than that of the Korean data. Anxiety and depression were negative factors associated with quality of life (p \u3c 0.05). Better community integration was a positive factor for physical quality of life and quality of life as measured by the WHOQOL-DIS module (p \u3c0.01). Conclusion: The quality of life of adults with chronic spinal cord injury in mainland China was lower compared with reference populations. Duration of spinal cord injury, sex, community integration, anxiety, and depression were related to quality of life

Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease

Healthy expansion of adipose tissue is critical for the maintenance of metabolic health, providing an optimized reservoir for energy storage in the form of triacylglycerol-rich lipoproteins. Dysfunctional adipocytes that are unable to efficiently store lipid can result in lipodystrophy and contribute to nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. Leucine-rich repeat containing protein 8a/SWELL1 functionally encodes the volume-regulated anion channel complex in adipocytes, is induced in early obesity, and is required for normal adipocyte expansion during high-fat feeding. Adipose-specific SWELL1 ablation (Adipo KO) leads to insulin resistance and hyperglycemia during caloric excess, both of which are associated with NAFLD. Here, we show that Adipo-KO mice exhibited impaired adipose depot expansion and excess lipolysis when raised on a variety of high-fat diets, resulting in increased diacylglycerides and hepatic steatosis, thereby driving liver injury. Liver lipidomic analysis revealed increases in oleic acid-containing hepatic triacylglycerides and injurious hepatic diacylglyceride species, with reductions in hepatocyte-protective phospholipids and antiinflammatory free fatty acids. Aged Adipo-KO mice developed hepatic steatosis on a regular chow diet, and Adipo-KO male mice developed spontaneous, aggressive hepatocellular carcinomas (HCCs). These data highlight the importance of adipocyte SWELL1 for healthy adipocyte expansion to protect against NAFLD and HCC in the setting of overnutrition and with aging

Effects of a Rehabilitation Program for Individuals with Chronic Spinal Cord Injury in Shanghai, China

Background: Specialized Institution-Based Rehabilitation (SIBR) is the cornerstone of care and treatment for individuals with spinal cord injury, but most people with chronic spinal cord injury (CSCI) living in China have no SIBR experience after acute care hospital discharge. In 2009, an SIBR facility was set up in Shanghai (China) to fill this important gap in care. The purpose of the study was to evaluate the effectiveness of an integrated rehabilitation training program among individuals with CSCI living in Shanghai. Methods: A within-subject pre-posttest design was used to evaluate the SIBR. The sample included 455 individuals ≥1 year post-SCI, who were older than 18 years of age and were enrolled in a rehabilitation center in Shanghai, China, between 2013 and 2019. The data included individuals’ sociodemographic and injury characteristics, and twenty-three indicators were used as outcome measurements to evaluate basic life skills and their applications in family and social life. Multivariate linear regression was conducted to determine which factors might have influenced the effectiveness of the SIBR. Results: All basic life skills and their applications in family and social life were improved, but with variations across socio-demographics. Female individuals with CSCI had better outcomes in basic life skills than did males. In terms of basic life skills and their applications in family and social life, individuals with a low level (thoracic or lumbosacral) of injury achieved more significant functional gains than those with a higher level (cervical). The baseline score was also a relevant factor in functional outcome. Conclusions: Even for individuals with a long SCI history, SIBR training can improve basic life skills and the applications of those skills in family and social life settings