XMM-Newton and VLT observations of the isolated neutron star 1E 1207.4-5209

In August 2002, XMM-Newton devoted two full orbits to the observation of 1E 1207.4-5209, making this isolated neutron star the most deeply scrutinized galactic target of the mission. Thanks to the high throughput of the EPIC instrument, ~360,000 photons were collected from the source, allowing for a very sensitive study of the temporal and spectral behaviour of this object. The spectral data, both time-averaged and phase-resolved, yield one compelling interpretation of the observed features: cyclotron absorption from one fundamental (~0.7 keV) and three harmonics, at ~1.4, ~2.1 and ~2.8 keV. Possible physical consequences are discussed, also on the basis of the obvious phase variations of the features' shapes and depths. We also present deep VLT optical data which we have used to search for a counterpart, with negative results down to ~27.Comment: 25 pages, 9 postscript figures. Accepted for publication in Astronomy & Astrophysic

Lithographed spectrometers for tomographic line mapping of the Epoch of Reionization

The Tomographic Ionized carbon Mapping Experiment (TIME) is a multi-phased experiment that will topographically map [CII] emission from the Epoch of Reionization. We are developing lithographed spectrometers that couple to TES bolometers in anticipation of the second generation instrument. Our design intentionally mirrors many features of the parallel SuperSpec project, inductively coupling power from a trunk-line microstrip onto half-wave resonators. The resonators couple to a rat-race hybrids that feeds TES bolometers. Our 25 channel prototype shows spectrally positioned lines roughly matching design with a receiver optical efficiency of 15-20%, a level that is dominated by loss in components outside the spectrometer

The isolated neutron star X-ray pulsars RX J0420.0–5022 and RX J0806.4–4123 : new X-ray and optical observations

We report on the analysis of new X-ray data obtained with XMM-Newton and Chandra from two ROSAT-discovered X-ray dim isolated neutron stars (XDINs). RX J0806.4−4123 was observed with XMM-Newton in April 2003, 2.5 years after the first observation. The EPIC-pn data confirm that this object is an X-ray pulsar with 11.371 s neutron star spin period. The X-ray spectrum is consistent with absorbed black-body emission with a temperature kT = 96 eV and N H = 4 × 10 19 cm −2 without significant changes between the two observations. Four XMM-Newton observations of RX J0420.0−5022 between December 2002 and July 2003 did not confirm the 22.7 s pulsations originally indicated in ROSAT data, but clearly reveal a 3.453 s period. A fit to the X-ray spectrum using an absorbed black-body model yields kT = 45 eV, the lowest value found from the small group of XDINs and N H = 1.0 × 10 20 cm −2. Including a broad absorption line improves the quality of the spectral fits considerably for both objects and may indicate the presence of absorption features similar to those reported from RBS1223, RX J1605.3+3249 and RX J0720.4−3125. For both targets we derive accurate X-ray positions from the Chandra data and present an optical counterpart candidate for RX J0420.0−5022 with B = 26.6 ± 0.3 mag from VLT imaging

Galaxy evolution: black hole feedback in the luminous quasar PDS 456

The evolution of galaxies is connected to the growth of supermassive black holes in their centers. During the quasar phase, a huge luminosity is released as matter falls onto the black hole, and radiation-driven winds can transfer most of this energy back to the host galaxy. Over five different epochs, we detected the signatures of a nearly spherical stream of highly ionized gas in the broadband x-ray spectra of the luminous quasar PDS 456. This persistent wind is expelled at relativistic speeds from the inner accretion disk, and its wide aperture suggests an effective coupling with the ambient gas. The outflow's kinetic power larger than 10(46) ergs per second is enough to provide the feedback required by models of black hole and host galaxy coevolution

Resource Modelling: The Missing Piece of the HTA Jigsaw?

Within health technology assessment (HTA), cost-effectiveness analysis and budget impact analyses have been broadly accepted as important components of decision making. However, whilst they address efficiency and affordability, the issue of implementation and feasibility has been largely ignored. HTA commonly takes place within a deliberative framework that captures issues of implementation and feasibility in a qualitative manner. We argue that only through a formal quantitative assessment of resource constraints can these issues be fully addressed. This paper argues the need for resource modelling to be considered explicitly in HTA. First, economic evaluation and budget impact models are described along with their limitations in evaluating feasibility. Next, resource modelling is defined and its usefulness is described along with examples of resource modelling from the literature. Then, the important issues that need to be considered when undertaking resource modelling are described before setting out recommendations for the use of resource modelling in HTA

Annual research review: Digital health interventions for children and young people with mental health problems: a systematic and meta-review

Digital health interventions (DHIs), including computer-assisted therapy, smartphone apps and wearable technologies, are heralded as having enormous potential to improve uptake and accessibility, efficiency, clinical effectiveness and personalisation of mental health interventions. It is generally assumed that DHIs will be preferred by children and young people (CYP) given their ubiquitous digital activity. However, it remains uncertain whether: DHIs for CYP are clinically and cost-effective, CYP prefer DHIs to traditional services, DHIs widen access and how they should be evaluated and adopted by mental health services. This review evaluates the evidence-base for DHIs and considers the key research questions and approaches to evaluation and implementation. We conducted a meta-review of scoping, narrative, systematic or meta-analytical reviews investigating the effectiveness of DHIs for mental health problems in CYP. We also updated a systematic review of randomised controlled trials (RCTs) of DHIs for CYP published in the last 3 years. Twenty-one reviews were included in the meta-review. The findings provide some support for the clinical benefit of DHIs, particularly computerised cognitive behavioural therapy (cCBT), for depression and anxiety in adolescents and young adults. The systematic review identified 30 new RCTs evaluating DHIs for attention deficit/hyperactivity disorder (ADHD), autism, anxiety, depression, psychosis, eating disorders and PTSD. The benefits of DHIs in managing ADHD, autism, psychosis and eating disorders are uncertain, and evidence is lacking regarding the cost-effectiveness of DHIs. Key methodological limitations make it difficult to draw definitive conclusions from existing clinical trials of DHIs. Issues include variable uptake and engagement with DHIs, lack of an agreed typology/taxonomy for DHIs, small sample sizes, lack of blinded outcome assessment, combining different comparators, short-term follow-up and poor specification of the level of human support. Research and practice recommendations are presented that address the key research questions and methodological issues for the evaluation and clinical implementation of DHIs for CYP

Streptococcus pyogenes colonization in children aged 24-59 months in The Gambia: Impact of Live Attenuated Influenza Vaccine and associated serological responses

BACKGROUND: Immunity to Streptococcus pyogenes in high burden settings is poorly understood. We explored S. pyogenes nasopharyngeal colonization after intranasal live attenuated influenza vaccine (LAIV) among Gambian children aged 24-59 months, and resulting serological response to 7 antigens. METHODS: A post-hoc analysis was performed in 320 children randomized to receive LAIV at baseline (LAIV group) or not (control). S. pyogenes colonization was determined by quantitative Polymerase Chain Reaction (qPCR) on nasopharyngeal swabs from baseline (D0), day 7 (D7) and day 21 (D21). Anti-streptococcal IgG was quantified, including a subset with paired serum pre/post S. pyogenes acquisition. RESULTS: The point prevalence of S. pyogenes colonization ranged from 7-13%. In children negative at D0, S. pyogenes was detected at D7 or D21 in 18% of LAIV group and 11% of control group participants (p=0.12). The odds ratio (OR) for colonization over time was significantly increased in the LAIV group (D21 vs D0 OR 3.18, p=0.003) but not in the control group (OR 0.86, p=0.79). The highest IgG increases following asymptomatic colonization were seen for M1 and SpyCEP proteins. CONCLUSIONS: Asymptomatic S. pyogenes colonization appears modestly increased by LAIV, and may be immunologically significant. LAIV could be used to study influenza-S. pyogenes interactions