Extraction of pharmacokinetic evidence of drug-drug interactions from the literature

Drug-drug interaction (DDI) is a major cause of morbidity and mortality and a subject of intense scientific interest. Biomedical literature mining can aid DDI research by extracting evidence for large numbers of potential interactions from published literature and clinical databases. Though DDI is investigated in domains ranging in scale from intracellular biochemistry to human populations, literature mining has not been used to extract specific types of experimental evidence, which are reported differently for distinct experimental goals. We focus on pharmacokinetic evidence for DDI, essential for identifying causal mechanisms of putative interactions and as input for further pharmacological and pharmacoepidemiology investigations. We used manually curated corpora of PubMed abstracts and annotated sentences to evaluate the efficacy of literature mining on two tasks: first, identifying PubMed abstracts containing pharmacokinetic evidence of DDIs; second, extracting sentences containing such evidence from abstracts. We implemented a text mining pipeline and evaluated it using several linear classifiers and a variety of feature transforms. The most important textual features in the abstract and sentence classification tasks were analyzed. We also investigated the performance benefits of using features derived from PubMed metadata fields, various publicly available named entity recognizers, and pharmacokinetic dictionaries. Several classifiers performed very well in distinguishing relevant and irrelevant abstracts (reaching F10.93, MCC0.74, iAUC0.99) and sentences (F10.76, MCC0.65, iAUC0.83). We found that word bigram features were important for achieving optimal classifier performance and that features derived from Medical Subject Headings (MeSH) terms significantly improved abstract classification. We also found that some drug-related named entity recognition tools and dictionaries led to slight but significant improvements, especially in classification of evidence sentences. Based on our thorough analysis of classifiers and feature transforms and the high classification performance achieved, we demonstrate that literature mining can aid DDI discovery by supporting automatic extraction of specific types of experimental evidence.National Institutes of Health, National Library of Medicine Program, grant 01LM011945-01 "BLR: Evidence-based Drug-Interaction Discovery: In-Vivo, In-Vitro and Clinical," a grant from the Indiana University Collaborative Research Program 2013, "Drug-Drug Interaction Prediction from Large-scale Mining of Literature and Patient Records," as well as a grant from the joint program between the Fundação Luso-Americana para o Desenvolvimento (Portugal) and National Science Foundation (USA), 2012-2014, "Network Mining For Gene Regulation And Biochemical Signaling.

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Participation and empowerment : determining the healthcare organization's success

Introduction : An organization performs well with proper management methods. Participation is a process involving cooperation and collaboration within all levels of individuals, groups or community for the purpose of organization improvement. Empowerment brings the organization further by delegation of power and responsibilities to others for better result. Methodology : This is a systematic review on various publications, articles and studies based on the findings and researches conducted by experts and scholars involved with participation and empowerment of organisations Results : Participation and empowerment are crucial in every organization including healthcare. Its success depends on factors such as proper planning, mutual understanding, regular training and continuous education. They contribute towards better outcome in goal setting, decision making, problem solving and organizational development. There are also various levels of empowerment and participation depending on the type of activities, organisation’s performance and level of authority. Conclusion : The prerequisite for an organisation’s success is dependent upon holistic participation and appropriate empowerment. The benefits gained from these measures are indeed invaluable. It creates sense of ownership, increases motivation and satisfaction, optimizing resources, promote innovations, enhancing quality and improving efficiency

Prevalence of attention deficit hyperactivity disorder in schoolchildren in the city of Salvador, Bahia, Brazil Prevalência do transtorno de déficit de atenção e hiperatividade em escolares na cidade do Salvador, Bahia, Brasil

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is the most common neuropsychiatric disorder of infancy and one of the most prevalent chronic diseases found in schoolchildren. OBJECTIVE: To evaluate the prevalence of ADHD in schoolchildren through the use of a questionnaire responded by school-teachers. METHOD: A total of 774 children enrolled in the public and private school systems were evaluated. The diagnostic instrument used was a Teacher ADHD scale. RESULTS: Results showed that 6.7% of children were considered highly likely to have the disorder. Of the more severe cases of ADHD, the hyperactive-impulsive subtype was more frequently identified in girls, while the inattentive subtype was more prevalent among boys. CONCLUSION: The symptoms of attention deficit in hyperactive children may be underestimated by teachers since the symptoms of hyperactivity are more noticeable and disruptive.<br>INTRODUÇÃO: O transtorno de déficit de atenção e hiperatividade (TDAH) é o distúrbio neuropsiquiátrico mais comum na infância, estando, também, entre as doenças crônicas mais prevalentes em crianças escolares. OBJETIVO: Estimar a prevalência do TDAH em escolares através de inquérito com professores. MÉTODO: Foram avaliadas 774 crianças, matriculados na rede pública e privada de ensino. O instrumento diagnóstico utilizado foi a Escala de TDAH versão para professores. RESULTADOS: Estimou-se que 6,7% das crianças apresentavam alta probabilidade de apresentar o distúrbio. Dentre os casos mais severos de TDAH o subtipo hiperativo-impulsivo foi mais prevalente nos escolares do sexo feminino, enquanto o subtipo desatento foi mais prevalente entre as crianças do sexo masculino. CONCLUSÃO: Os sintomas do déficit de atenção em crianças hiperativas podem ser subestimados pelos professores visto que os sintomas da hiperatividade são mais disruptivos e visíveis

Força de preensão manual de atletas tenistas avaliada por diferentes recomendações de teste

A avaliação da força de preensão manual (FPM) em tenistas competitivos deve ser realizada devido à assimetria que o jogador pode desenvolver. Para avaliar a FPM, profissionais utilizam dois protocolos diferentes (das Sociedades Americana e Europeia). Os objetivos deste estudo foram comparar a FPM usando a técnica do European Test of Physical Fitness Handbook (Eurofit) e da American Society of Hand Therapists (ASHT), bem como verificar a FPM entre o lado dominante/contralateral e comparar a FPM entre as idades em atletas de tênis da categoria infanto-juvenil. Participaram do estudo 137 tenistas do gênero masculino e 45 do feminino, todos com idade entre oito e 18 anos. Para avaliar a FPM, segundo as recomendações da Eurofit e ASHT, foi utilizado um dinamômetro manual (Jamar). Nenhum dos sujeitos avaliados apresentava qualquer lesão que pudesse comprometer o teste. Os resultados mostram que não há diferença na FPM entre os posicionamentos recomendados pela Eurofit e ASHT para medir a FPM independente do gênero. A curva sigmoide foi a que melhor se adequou para regressão da FPM e idade em ambos os gêneros sendo que para o masculino a FPM tem maior inclinação aos 11 anos, já para o feminino a maior inclinação é aos 10 anos. Além disso, a partir dos 14 anos, o lado dominante dos atletas masculinos apresentou maior FPM que o lado não dominante; contudo, essa assimetria não ocorreu no feminino em qualquer idade até os 18 anos