478 research outputs found

    Rock Evaluation for Engineered Facilities

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    The need for comprehensive information on the characteristics and behavior of earth materials has been recognized for many years, perhaps for as long as significant construction has taken place in and on the surface of the earth. In recent years, however, the magnitude and complexity of engineered construction has greatly increased, resulting in a corresponding increase in the need for information on the engineering properties of soil and rock materials, Direct testing of soil and rock can be utilized to furnish necessary information. However, both field and laboratory testing can be extremely expensive, particularly where testing must include applications of stress to large masses of earth material, For this reason, significant technical and economic advantages can be realized through the development of indirect or short-cut methods for obtaining indications of the properties and characteristics of geologic materials. Some years ago the value of topographic maps, aerial photographs, pedologic descriptions, and geological surveys in characterizing soil materials was realized. To make this information useful for engineering studies, a serious effort was initiated to obtain data on the engineering properties of various soil groups and associations established on the basis of geological and pedological surveys. The correlation of performance data with information on areal distribution and location furnished by geologic and pedologic works has proven extremely valuable in the planning and construction of facilities in and on soil. In recent years, the size and importance of structures and facilities designed by engineers and architects has greatly increased. This has produced an increased interest in the rock materials underlying surficial soil layers. A clear need has arisen for a program to provide an engineering evaluation of rock materials for the purposes of location, design, construction, and maintenance of engineered facilities. However, a serious gap exists in the association of engineering characteristics with rock units identified on the basis of geological classifications, Therefore, there is a need for the development of a comprehensive evaluation program which permits utilization of existing data and which aids in the procurement of necessary information on engineering characteristics of rock

    Engineering Data System for Bedrock Occurrences and Properties

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    The initial work plan included the development of a classification system based on index tests. An investigation of previous works in classification of rock on the basis of index tests showed that a variety of classification systems utilizing many different index tests had been developed. However, this survey showed that no generally applicable system had been developed and that little communication had been established between field investigators, facility designers, and those in charge of construction and maintenance of facilities. Therefore, the initial plan for work was modified to include the development of a comprehensive methodology for evaluation of rock. The development of such an evaluation schema was to include the establishment of an information bank to provide access to collected data by any interested individual. The first step in the development of this rock evaluation program was a survey of the categories of information that have been collected concerning geologic materials, particularly rock strata. On the basis of this investigation of existing data, a method was devised to collect, categorize, and present more extensive data on rock materials. The general schema for the evaluation program was then developed. At the present time, a research effort is continuing to test and verify the validity of the evaluation program which has been developed. A final step in this effort will be a full implementation of the rock evaluation program for project planning in Kentucky

    Child Well-being in the Pacific Rim

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    This study extends previous efforts to compare the well-being of children using multi-dimensional indicators derived from sample survey and administrative series to thirteen countries in the Pacific Rim. The framework for the analysis of child well-being is to organise 46 indicators into 21 components and organise the components into 6 domains: material situation, health, education, subjective well-being, living environment, as well as risk and safety. Overall, Japan, Singapore and Taiwan have the highest child well-being and Thailand, Indonesia and the Philippines the lowest. However, there are substantial variations between the domains. Japan and Korea perform best on the material well-being of children and also do well on health and education but they have the lowest subjective well-being among their children by some margin. There is a relationship between child well-being and GDP per capita but children in China have higher well-being than you would expect given their GDP and children in Australia have lower well-being. The analysis is constrained by missing data particularly that the Health Behaviour of School-Aged Children Survey is not undertaken in any of these countries

    Phenotype-specific association of the TGFBR3 locus with nonsyndromic cryptorchidism

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    PURPOSE: Based on a genome-wide association study of testicular dysgenesis syndrome showing a possible association with TGFBR3, we analyzed data from a larger, phenotypically restricted cryptorchidism population for potential replication of this signal. MATERIALS AND METHODS: We excluded samples based on strict quality control criteria, leaving 844 cases and 2,718 controls of European ancestry that were analyzed in 2 separate groups based on genotyping platform (ie Illumina® HumanHap550, version 1 or 3, or Human610-Quad, version 1 BeadChip in group 1 and Human OmniExpress 12, version 1 BeadChip platform in group 2). Analyses included genotype imputation at the TGFBR3 locus, association analysis of imputed data with correction for population substructure, subsequent meta-analysis of data for groups 1 and 2, and selective genotyping of independent cases (330) and controls (324) for replication. We also measured Tgfbr3 mRNA levels and performed TGFBR3/betaglycan immunostaining in rat fetal gubernaculum. RESULTS: We identified suggestive (p ≤ 1× 10(-4)) association of markers in/near TGFBR3, including rs9661103 (OR 1.40; 95% CI 1.20, 1.64; p = 2.71 × 10(-5)) and rs10782968 (OR 1.58; 95% CI 1.26, 1.98; p = 9.36 × 10(-5)) in groups 1 and 2, respectively. In subgroup analyses we observed strongest association of rs17576372 (OR 1.42; 95% CI 1.24, 1.60; p = 1.67 × 10(-4)) with proximal and rs11165059 (OR 1.32; 95% CI 1.15, 1.38; p = 9.42 × 10(-4)) with distal testis position, signals in strong linkage disequilibrium with rs9661103 and rs10782968, respectively. Association of the prior genome-wide association study signal (rs12082710) was marginal (OR 1.13; 95% CI 0.99, 1.28; p = 0.09 for group 1), and we were unable to replicate signals in our independent cohort. Tgfbr3/betaglycan was differentially expressed in wild-type and cryptorchid rat fetal gubernaculum. CONCLUSIONS: These data suggest complex or phenotype specific association of cryptorchidism with TGFBR3 and the gubernaculum as a potential target of TGFβ signaling

    Impact of Gravel Dredging Operations on Surface Water Quality in Streams in the Upper Cumberland Basin

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    This is a report to the USEPA, Kentucky Division of Water and the Kentucky Water Resources Research Institute, focused on the biologic and morphological impacts of gravel mining in the upper Cumberland basin

    Chronic Stress, Sense of Belonging, and Depression Among Survivors of Traumatic Brain Injury

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    To test whether chronic stress, interpersonal relatedness, and cognitive burden could explain depression after traumatic brain injury (TBI). Design : A nonprobability sample of 75 mild-to-moderately injured TBI survivors and their significant others, were recruited from five TBI day-rehabilitation programs. All participants were within 2 years of the date of injury and were living in the community. Methods : During face-to-face interviews, demographic information, and estimates of brain injury severity were obtained and participants completed a cognitive battery of tests of directed attention and short-term memory, responses to the Perceived Stress Scale, Interpersonal Relatedness Inventory, Sense of Belonging Instrument, Neurobehavioral Functioning Inventory, and Center for Epidemiological Studies Depression Scale;. Findings : Chronic stress was significantly and positively related to post-TBI depression. Depression and postinjury sense of belonging were negatively related. Social support and results from the cognitive battery did not explain depression. Conclusions : Postinjury chronic stress and sense of belonging were strong predictors of post-injury depression and are variables amenable to interventions by nurses in community health, neurological centers, or rehabilitation clinics. Future studies are needed to examine how these variables change over time during the recovery process.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72593/1/j.1547-5069.2002.00221.x.pd

    Selecting and Certifying a Landing Site for Moonrise in South Pole-Aitken Basin

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    MoonRise is a New Frontiers mission concept to land in the South Pole-Aitken (SPA) basin, collect samples, and return the samples to Earth for detailed mineral, chemical, petrologic, geochronologic, and physical properties analyses to address science questions relevant to the early evolution of the Solar System and the Moon. Science associated with this mission concept is described elsewhere; here we discuss selection of sites within SPA to address science objectives using recent scientific studies (orbital spectroscopy, gravity, topography), and the use of new data (LRO) to certify safe landing sites for a robotic sample return mission such as MoonRise

    Apparent quality-of-life in nations : how long and happy people live

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    Quality-of-life in nations can be measured by how long and happy people live. This is assessed by combining data on life expectancy drawn from civil registration with survey data on subjective enjoyment of life as a whole. This measure of 'apparent' quality-of-life is a good alternative to current indexes of 'assumed' quality-of-life such as the Human Development Index. Data are available for 67 nations in the 1990s. The number of Happy-Life-Years varies considerably across nations. Switzerland is at the top with 63.0 years and Moldavia at the bottom with 20.5 years. China is in the middle with an average of 46.7. Happy lifetime has risen considerably in advanced nations over the last decade. People live longer and happier in nations characterised by economic affluence, freedom and justice. Together these three societal qualities explain 66% of the cross-national variance in Happy-Life-Years. Income equality and generous social security do not appear to be required for a long and happy life

    Upregulation of the Oct3/4 network in basal breast cancer is associated with its metastatic potential and shows tissue dependent variability

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    Adaptive plasticity of Breast Cancer stem cells (BCSCs) is strongly correlated with cancer progression and resistance, leading to a poor prognosis. In this study, we report the expression profile of several pioneer transcription factors of th
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