Flow through a lattice of airfoils with cascade angle of 30{112}0{115}

Thesis (M.A.)--Boston University, 1947. This item was digitized by the Internet Archive

Physiologic Acclimation of Southern Appalachian Red Spruce to Simulated Climatic Warming

Global air temperatures are predicted to rise 1° to 4.5°C by the year 2100 and perhaps greater at high latitudes. In order to correctly identify the effects of climate change on tree species, the present thesis is an assessment of the sensitivity, response and acclimation potential of southern Appalachian red spruce (Picea rubens Sarg.) to the impact of warming. This objective was approached through examinations of synthesis (instantaneous and short-term acclimation rates of photosynthesis and respiration) as well as investment (biomass accumulation and partitioning, growth rate, and carbohydrate allocation) of carbon assimilates. Red spruce from two southern Appalachian provenances were germinated and grown in two separate growth chambers set at day/night temperatures of 19.9/12.9°C and 23.9/16.9°C (means of 17° and 21°C). At weeks 8, 12 and 16 after germination, concurrent analyses of carbon gas exchange and biomass accumulation were conducted. Seedlings grown at 21ºC had low photosynthetic rates at week 8, but fully acclimated by week 16 to rates equal to seedlings grown at 17ºC. Daytime dark respiration and Q10 values remained near equal throughout the study duration and showed minimal dependence on treatment temperature. Despite equivalent carbon assimilation, seedlings grown at the low temperature had significantly lower whole plant mass at every measurement date. Throughout the study duration, plants grown at 17ºC allocated more mass to roots, while seedlings in our elevated temperature partitioned more to foliage. Relative growth rate was 154% greater for plants grown at 21ºC than for plants at 17ºC. As supply of photosynthate surpassed growth demand for seedlings grown at low temperature conditions, these seedlings had higher concentrations of starch in both roots and shoots. We conclude that carbon assimilation in southern Appalachian red spruce has the potential for physiological acclimation to temperature. As the cool adapted spruce seedlings performed better at 21ºC rather than at 17ºC, as displayed by increased growth rate and dry mass accumulation, we question the temperature limitations of the deciduous-boreal ecotone as it relates to this species. Interspecific variations to warmer temperatures leading to modifications in interspecific competition may be a greater determinate of a displacement of this ecotone

Patient and community nurse perspectives on recruitment to a randomized controlled trial of urinary catheter washout solutions

Aims To provide evidence around the acceptability of a proposed randomised controlled trial (RCT) of catheter washout solutions. Design: A sample of senior community nursing staff (n=7) were interviewed and four focus groups with a sample of community nurses were conducted. Eleven semi-structured face-to-face interviews were undertaken with patients using a long-term catheter. Methods: An in-depth qualitative study using a phenomenological approach was employed. This approach was suitable to explore the lived experiences of subjects and gain their viewpoints and experiences. Results: Nurse participants raised concerns regarding the removal of treatment or increased risk of infection in relation to which arm of the trial patients were randomised to. There was concern that patients could get used to the increased contact with nursing staff. Six patients who agreed to participate cited personal benefit, benefiting others, and a sense of indifference. Four patients were unsure about taking part and one declined

Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus

The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein. However, the connection between p53 and the dynein motor protein complex has not been established. Here, we show that hsp90.binding immunophilins link p53.hsp90 complexes to dynein and that prevention of that linkage in vivo inhibits the nuclear movement of p53. First, we show that p53.hsp90 heterocomplexes from DLD-1 human colon cancer cells contain an immunophilin (FKBP52, CyP-40, or PP5) as well as dynein. p53.hsp90.immunophilin.dynein complexes can be formed by incubating immunopurified p53 with rabbit reticulocyte lysate, and we show by peptide competition that the immunophilins link via their tetratricopeptide repeat domains to p53-bound hsp90 and by means of their PPIase domains to the dynein complex. The linkage of immunophilins to the dynein motor is indirect by means of the dynamitin component of the dynein-associated dynactin complex, and we show that purified FKBP52 binds directly by means of its PPIase domain to purified dynamitin. By using a temperature-sensitive mutant of p53 where cytoplasmic-nuclear movement occurs by shift to permissive temperature, we show that p53 movement is impeded when p53 binding to hsp90 is inhibited by the hsp90 inhibitor radicicol. Also, nuclear movement of p53 is inhibited when immunophilin binding to dynein is competed for by expression of a PPIase domain fragment in the same manner as when dynein linkage to cargo is dissociated by expression of dynamitin. This is the first demonstration of the linkage between an hsp90-chaperoned transcription factor and the system for its retrograde movement to the nucleus both in vitro and in vivo.Fil: Galigniana, Mario Daniel. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Harrell, Jennifer M.. University of Michigan; Estados UnidosFil: O´Hagen, Heather M.. University of Michigan; Estados UnidosFil: Ljungman, Mats. University of Michigan; Estados UnidosFil: Pratt, William B.. University of Michigan; Estados Unido

Pipe inspection and repair system

A multi-module pipe inspection and repair device. The device includes a base module, a camera module, a sensor module, an MFL module, a brush module, a patch set/test module, and a marker module. Each of the modules may be interconnected to construct one of an inspection device, a preparation device, a marking device, and a repair device

Psychometric properties of the Arabic version of the international consultation on incontinence questionnaire on long-term catheter quality of life

Aim To translate the International Consultation on Incontinence Questionnaire (ICIQ) Long-Term Catheter Quality of Life (LTCqol) questionnaire (ICIQ-LTCqol) questionnaire from English to Arabic and evaluate its psychometric properties. Background Currently, no tool for Arabic speaking patients is available to measure the quality of life in patients using long-term urinary catheters. Design Translation and psychometric assessment of questionnaire. Methods The internal consistency and construct validity of the translated Arabic version of the ICIQ-LTCqol were evaluated in a convenience sample of 141 participants recruited from a hospital in Egypt from April to September 2017. Test-retest reliability was assessed for a sample of 15 participants who completed this version at two-time points. Construct validity was assessed by factor analysis. Results The translated Arabic version of the ICIQ-LTCqol showed satisfactory test-retest reliability and internal consistency, with Cronbach’s α = 0·75. Confirmatory factor analysis confirmed the same two factors (‘catheter function’ and ‘lifestyle’) structure as found in the English version of the tool supporting the construct validity of the translated questionnaire. Conclusion This original and significant study allows, for the first time, researchers and clinicians working with Arabic speaking patients, the opportunity to evaluate the quality of life in long-term urinary catheter users

Month-Timescale Optical Variability in the M87 Jet

A previously inconspicuous knot in the M87 jet has undergone a dramatic outburst and now exceeds the nucleus in optical and X-ray luminosity. Monitoring of M87 with the Hubble Space Telescope and Chandra X-ray Observatory during 2002-2003, has found month-timescale optical variability in both the nucleus and HST-1, a knot in the jet 0.82'' from the nucleus. We discuss the behavior of the variability timescales as well as spectral energy distribution of both components. In the nucleus, we see nearly energy-independent variability behavior. Knot HST-1, however, displays weak energy dependence in both X-ray and optical bands, but with nearly comparable rise/decay timescales at 220 nm and 0.5 keV. The flaring region of HST-1 appears stationary over eight months of monitoring. We consider various emission models to explain the variability of both components. The flares we see are similar to those seen in blazars, albeit on longer timescales, and so could, if viewed at smaller angles, explain the extreme variability properties of those objects.Comment: 4 pages, 3 figures, ApJ Lett., in pres