2,667 research outputs found
De invloed van kleur en licht op de stationsbeleving:Kleur en licht op het perron: Twee virtuele experimenten
Uit diverse onderzoeken blijkt dat kleuren en licht onze emoties en ons gedrag beïnvloeden. In dit paper worden de resultaten gepresenteerd van onderzoek naar de gecombineerde effecten van 5 verschillende kleuren en 2 verschillende lichtsterktes voor station Leiden. Uit twee experimenten in een virtueel station Leiden blijkt dat kleur en licht onbewust worden waargenomen, maar dat de combinatie van kleur en licht wel significante effecten heeft op een aantal affectieve aspecten en op de wachttijdbeleving. Significante verschillen zijn gevonden voor reacties op kleur en licht tussen mannen en vrouwen, tussen gehaaste (must)reizigers en ontspannen (lust)reizigers en tussen een drukke omgeving en een rustige omgeving. Verder blijkt dat de meeste reizigers de wachttijd op het perron ruim overschatten, wat aansluit bij resultaten uit eerder veldwerk. Ook blijkt dat bij een gedimde verlichting de tijd sneller lijkt te verstrijken dan bij een hoog lichtniveau. Uit het tweede experiment blijkt dat lustreizigers meer open staan voor prikkels uit de omgeving dan mustreizigers. Zij prefereren vooral warme kleuren in combinatie met gedimde verlichting en schatten de wachttijd korter in dan bij het gebruik van koele kleuren en een hoger verlichtingsniveau. De waardering van het wachten en hoe nuttig reizigers de wachttijd vinden, bepalen zowel de attitude van het perron als het oordeel over het perron. Uit het tweede experiment blijkt verder dat de wachttijdbeleving erg dicht bij de basisemoties pleasure, arousal en dominance liggen. Voor de stationsomgeving blijken gevoelens, of emoties die worden opgeroepen door de wachttijd, aan deze basisemoties te kunnen worden toegevoegd
Flux flow resistivity and vortex viscosity of high-Tc films
The flux flow regime of high-T samples of different normal state
resistivities is studied in the temperature range where the sign of the Hall
effect is reversed. The scaling of the vortex viscosity with normal state
resistivity is consistent with the Bardeen-Stephen theory. Estimates of the
influence of possible mechanisms suggested for the sign reversal of the Hall
effect are also given.Comment: 3 pages. 4 figures upon reques
Electrostatics of Vortices in Type II Superconductors
In a type II superconductor the gap variation in the core of a vortex line
induces a local charge modulation. Accounting for metallic screening, we
determine the line charge of individual vortices and calculate the electric
field distribution in the half space above a field penetrated superconductor.
The resulting field is that of an atomic size dipole , is the Bohr radius, acting
on a force microscope in the pico to femto Newton range.Comment: 9 pages, late
Focusing by blocking: repeatedly generating central density peaks in self-propelled particle systems by exploiting diffusive processes
Over the past few years the displacement statistics of self-propelled
particles has been intensely studied, revealing their long-time diffusive
behavior. Here, we demonstrate that a concerted combination of boundary
conditions and switching on and off the self-propelling drive can generate and
afterwards arbitrarily often restore a non-stationary centered peak in their
spatial distribution. This corresponds to a partial reversibility of their
statistical behavior, in opposition to the above-mentioned long-time diffusive
nature. Interestingly, it is a diffusive process that mediates and makes
possible this procedure. It should be straightforward to verify our predictions
in a real experimental system.Comment: 6 pages, 6 figure
Somatostatin analogues for receptor targeted photodynamic therapy
Photodynamic therapy (PDT) is an established treatment modality, used mainly for anticancer therapy that relies on the interaction of photosensitizer, light and oxygen. For the treatment of pathologies in certain anatomical sites, improved targeting of the photosensitizer is necessary to prevent damage to healthy tissue. We report on a novel dual approach of targeted PDT (vascular and cellular targeting) utilizing the expression of neuropeptide somatostatin receptor (sst2) on tumor and neovascular-endothelial cells. We synthesized two conjugates containing the somatostatin analogue [Tyr3]-octreotate and Chlorin e6 (Ce6): Ce6-K3-[Tyr3]-octreotate (1) and Ce6-[Tyr3]-octreotate-K3-[Tyr3]-octreotate (2). Investigation of the uptake and photodynamic activity of conjugates in-vitro in human erythroleukemic K562 cells showed that conjugation of [Tyr3]-octreotate with Ce6 in conjugate 1 enhances uptake (by a factor 2) in cells over-expressing sst2 compared to wild-type cells. Co-treatment with excess free Octreotide abrogated the phototoxicity of conjugate 1 indicative of a specific sst2-mediated effect. In contrast conjugate 2 showed no receptor-mediated effect due to its high hydrophobicity. When compared with un-conjugated Ce6, the PDT activity of conjugate 1 was lower. However, it showed higher photostability which may compensate for its lower phototoxicity. Intra-vital fluorescence pharmacokinetic studies of conjugate 1 in rat skin-fold observation chambers transplanted with sst2+ AR42J acinar pancreas tumors showed significantly different uptake profiles compared to free Ce6. Co-treatment with free Octreotide significantly reduced conjugate uptake in tumor tissue (by a factor 4) as well as in the chamber neo-vasculature. These results show that conjugate 1 might have potential as an in-vivo sst2 targeting photosensitizer conjugate
Quantized Roentgen Effect in Bose-Einstein Condensates
A classical dielectric moving in a charged capacitor can create a magnetic
field (Roentgen effect). A quantum dielectric, however, will not produce a
magnetization, except at vortices. The magnetic field outside the quantum
dielectric appears as the field of quantized monopoles
International course on water and water management in the Philippines: 4 January - 31 January 2017
Since 2011, the Faculty of Social Sciences (FSW) and the Institute of Environmental Sciences (CML) of Leiden University, in cooperation with Isabela State University and the Mabuwaya Foundation in the Philippines organize an annual month–long international, interdisciplinary course on sustainable development, water issues and water management in the Cagayan River basin in Northeast Luzon in the Philippines. Thirty students participate in this course, 15 through Leiden University and 15 through Isabela State University. The students are enrolled in different studies, encompassing social, natural and applied sciences. The annual report contains background information, all student reports and the online blog that the students maintained during the course.Environmental BiologyGlobal Challenges (FSW
Colocalization of ANCA-antigens and fibrinoid necrosis in ANCA-associated vasculitis
Colocalization of ANCA-antigens and fibrinoid necrosis in ANCA-associated vasculitis. A variety of antineutrophil cytoplasmic auto-antibodies (ANCAs) are known to be associated with small vessel vasculitides such as Wegener's granulomatosis and microscopic polyangiitis. To visualize colocalization patterns of the fibrinoid necrotic lesions and ANCA-antigens more accurately, we have developed a double staining technique in which an immunohistochemical staining is followed by a histological staining. Instead of using sequential biopsy slides of histologically and immunohistochemically stained sections, which may lead to an underestimation of the number and size of the lesions, our technique permits the visualization of the colocalized patterns of fibrinoid necrosis with an ANCA-antigen in a single slide. The double staining procedure is presented in this Technical Note
Chiral three-nucleon forces and bound excited states in neutron-rich oxygen isotopes
We study the spectra of neutron-rich oxygen isotopes based on chiral two- and
three-nucleon interactions. First, we benchmark our many-body approach by
comparing ground-state energies to coupled-cluster results for the same
two-nucleon interaction, with overall good agreement. We then calculate bound
excited states in 21,22,23O, focusing on the role of three-nucleon forces, in
the standard sd shell and an extended sdf7/2p3/2 valence space. Chiral
three-nucleon forces provide important one- and two-body contributions between
valence neutrons. We find that both these contributions and an extended valence
space are necessary to reproduce key signatures of novel shell evolution, such
as the N = 14 magic number and the low-lying states in 21O and 23O, which are
too compressed with two-nucleon interactions only. For the extended space
calculations, this presents first work based on nuclear forces without
adjustments. Future work is needed and open questions are discussed.Comment: 6 pages, 4 figures, published versio
- …