Design of a Spherical Fuel Element for a Gas Cooled Fast Reactor

A study is done to develop a fuel cycle for a Gas Cooled Fast Reactor (GCFR). The design goals are: highly efficient use of (depleted) uranium, application of Pu recycled from LWR discharge as fissile material, high temperature output, and simplicity of design. The design focuses on spherical TRISO-like fuel elements, a homogeneous core at startup, providing for easy fuel fabrication, and self-breeding capability with a flat keff with burnup. Nitride fuel (15N > 99%) has been selected because of it's favourable thermal conductivity, high Heavy Metal density and compatability with PUREX reprocessing. Two core concepts have been studied: one with coated particles embedded inside fuel pebbles, and one with coated particles cooled directly by helium. The result is that a flat keff can be achieved for a long period of time, using coated particles cooled directly, with a homogeneous core at startup, with a closed fuel cycle and a simple refueling and reprocessing scheme

Droge duinvegetatie zeer zuinig met water

Over de gevolgen van droogte voor de soortensamenstelling en de verdamping van grondwateronafhankelijke duinvegetaties is heel weinig bekend. Op basis van verkennend onderzoek verwachten we dat meer droogte in de zomer leidt tot een toename van het aandeel mossen en kale grond. Daardoor daalt de verdamping en neemt de winderosie toe. Klimaatverandering zou zo gunstig kunnen uitpakken voor zowel de noodzakelijke dynamiek in het duin, als voor de aanvulling van de ondergrond met neerslagwate

Ondergrondse schimmeloorlog stuurt de ontwikkeling van een plantengemeenschap in de duinen

Plant science

TERRA-Dunes: natuurherstel in de duinen met bodemtransplantaties

Environmental Biolog

Impact of employee motivation on passenger satisfaction levels – A case study in the state of Karnataka (India)

Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

Ultra-thin corrugated metamaterial film as large-area transmission dynode

Large-area transmission dynodes were fabricated by depositing an ultra-thin continuous film on a silicon wafer with a 3-dimensional pattern. After removing the silicon, a corrugated membrane with enhanced mechanical properties was formed. Mechanical materials, such as this corrugated membrane, are engineered to improve its strength and robustness, which allows it to span a larger surface in comparison to flat membranes while the film thickness remains constant. The ultra-thin film consists of three layers (Al$_2$O$_3$ /TiN/Al$_2$O$_3$) and is deposited by atomic layer deposition (ALD). The encapsulated TiN layer provides in-plane conductivity, which is needed to sustain secondary electron emission. Two types of corrugated membranes were fabricated: a hexagonal honeycomb and an octagonal pattern. The latter was designed to match the square pitch of a CMOS pixel chip. The transmission secondary electron yield was determined with a collector-based method using a scanning electron microscope. The highest transmission electron yield was measured on a membrane with an octagonal pattern. A yield of 2.15 was achieved for 3.15 keV incident electrons for an Al$_2$O$_3$ /TiN/Al$_2$O$_3$ tri-layer film with layer thicknesses of 10/5/15 nm. The variation in yield across the surface of the corrugated membrane was determined by constructing a yield map. The active surface for transmission secondary electron emission is near 100%, i.e. a primary electron generates transmission secondary electrons regardless of the point of impact on the corrugated membrane

TNF- α augments intratumoural concentrations of doxorubicin in TNF- α -based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects

We have shown previously that isolated limb perfusion (ILP) in sarcoma-bearing rats results in high response rates when melphalan is used in combination with tumour necrosis factor alpha (TNF-α). This is in line with observations in patients. Here we show that ILP with doxorubicin in combination with TNF-α has comparable effects in two different rat sarcoma tumour models. The addition of TNF-α exhibits a synergistic anti-tumour effect, resulting in regression of the tumour in 54% and 100% of the cases for the BN175-fibrosarcoma and the ROS-1 osteosarcoma respectively. The combination is shown to be mandatory for optimal tumour response. The effect of high dose TNF-α on the activity of cytotoxic agents in ILP is still unclear. We investigated possible modes by which TNF-α could modulate the activity of doxorubicin. In both tumour models increased accumulation of doxorubicin in tumour tissue was found: 3.1-fold in the BN175 and 1.8-fold in the ROS-1 sarcoma after ILP with doxorubicin combined with TNF-α in comparison with an ILP with doxorubicin alone. This increase in local drug concentration may explain the synergistic anti-tumour responses after ILP with the combination. In vitro TNF-α fails to augment drug uptake in tumour cells or to increase cytotoxicity of the drug. These findings make it unlikely that TNF-α directly modulates the activity of doxorubicin in vivo. As TNF-α by itself has no or only minimal effect on tumour growth, an increase in local concentrations of chemotherapeutic drugs might well be the main mechanism for the synergistic anti-tumour effects. © 2000 Cancer Research Campaig

Hydroxychloroquine decreases human MSC-derived osteoblast differentiation and mineralization in vitro

We recently showed that patients with primary Sjögren Syndrome (pSS) have significantly higher bone mineral density (BMD) compared to healthy controls. The majority of those patients (69%) was using hydroxychloroquine (HCQ), which may have favourable effects on BMD. To study the direct effects of HCQ on human MSC-derived osteoblast activity. Osteoblasts were cultured from human mesenchymal stromal cells (hMSCs). Cultures were treated with different HCQ doses (control, 1 and 5 µg/ml). Alkaline phosphatase activity and calcium measurements were performed to evaluate osteoblast differentiation and activity, respectively. Detailed microarray analysis was performed in 5 µg/ml HCQ-treated cells and controls followed by qPCR validation. Additional cultures were performed using the cholesterol synthesis inhibitor simvastatin (SIM) to evaluate a potential mechanism of action. We showed that HCQ inhibits both MSC-derived osteoblast differentiation and mineralization in vitro. Microarray analysis and additional PCR validation reveale