1,193 research outputs found
WHAM Observations of H-alpha Emission from High Velocity Clouds in the M, A, and C Complexes
The first observations of the recently completed Wisconsin H-Alpha Mapper
(WHAM) facility include a study of emission lines from high velocity clouds in
the M, A, and C complexes, with most of the observations on the M I cloud. We
present results including clear detections of H-alpha emission from all three
complexes with intensities ranging from 0.06 R to 0.20 R. In every observed
direction where there is significant high velocity H I gas seen in the 21 cm
line we have found associated ionized hydrogen emitting the H-alpha line. The
velocities of the H-alpha and 21 cm emission are well correlated in every case
except one, but the intensities are not correlated. There is some evidence that
the ionized gas producing the H-alpha emission envelopes the 21 cm emitting
neutral gas but the H-alpha "halo", if present, is not large. If the H-alpha
emission arises from the photoionization of the H I clouds, then the implied
Lyman continuum flux F_{LC} at the location of the clouds ranges from 1.3 to
4.2 x 10^5 photons cm^{-2} s^{-1}. If, on the other hand, the ionization is due
to a shock arising from the collision of the high-velocity gas with an ambient
medium in the halo, then the density of the pre-shocked gas can be constrained.
We have also detected the [S II] 6716 angstrom line from the M I cloud and have
evidence that the [S II] to H-alpha ratio varies with location on the cloud.Comment: 32 pages, 18 figures, to appear in ApJ (Sept. 10, 1998
Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach
AIMS/HYPOTHESIS: Twin and family studies have shown the importance of genetic factors influencing fasting and 2 h glucose and insulin levels. However, the genetics of the physiological response to a glucose load has not been thoroughly investigated. METHODS: We studied 580 monozygotic and 1,937 dizygotic British female twins from the Twins UK Registry. The effects of genetic and environmental factors on fasting and 2 h glucose and insulin levels were estimated using univariate genetic modelling. Bivariate model fitting was used to investigate the glucose and insulin responses to a glucose load, i.e. an OGTT. RESULTS: The genetic effect on fasting and 2 h glucose and insulin levels ranged between 40% and 56% after adjustment for age and BMI. Exposure to a glucose load resulted in the emergence of novel genetic effects on 2 h glucose independent of the fasting level, accounting for about 55% of its heritability. For 2 h insulin, the effect of the same genes that already influenced fasting insulin was amplified by about 30%. CONCLUSIONS/INTERPRETATION: Exposure to a glucose challenge uncovers new genetic variance for glucose and amplifies the effects of genes that already influence the fasting insulin level. Finding the genes acting on 2 h glucose independently of fasting glucose may offer new aetiological insight into the risk of cardiovascular events and death from all causes
Distribution and Kinematics of O VI in the Galactic Halo
FUSE spectra of 100 extragalactic objects are analyzed to obtain measures of
O VI absorption along paths through the Milky Way thick disk/halo. Strong O VI
absorption over the approximate velocity range from -100 to 100 km/s reveals a
widespread but highly irregular distribution of thick disk O VI, implying the
existence of substantial amounts of hot gas with T ~ 3x10^5 K in the Milky Way
halo. Large irregularities in the distribution of the absorbing gas are found
to be similar over angular scales extending from less than one to 180 degrees,
indicating a considerable amount of small and large scale structure in the gas.
The overall distribution of Galactic O VI is not well described by a
symmetrical plane-parallel layer of patchy O VI absorption. The simplest
departure from such a model that provides a reasonable fit to the observations
is a plane-parallel patchy absorbing layer with a scale height of 2.3 kpc, and
a 0.25 dex excess of O VI in the northern Galactic polar region. The O VI
absorption has a Doppler parameter b = 30 to 99 km/s, with an average value of
60 km/s . Thermal broadening alone cannot explain the large observed profile
widths. The average O VI absorption velocities toward high latitude objects
range from -46 to 82 km/s, with a sample average of 0 km/s and a standard
deviation of 21 km/s. O VI associated with the thick disk moves both toward and
away from the plane with roughly equal frequency. A combination of models
involving the radiative cooling of hot fountain gas, the cooling of supernova
bubbles in the halo, and the turbulent mixing of warm and hot halo gases is
required to explain the presence of O VI and other highly ionized atoms found
in the halo. (abbreviated)Comment: 70 pages, single-spaced, PDF format. Bound copies of this manuscript
and two accompanying articles are available upon request. Submitted to ApJ
Dual-Frequency Observations of 140 Compact, Flat-Spectrum Active Galactic Nuclei for Scintillation-Induced Variability
The 4.9 GHz Micro-Arcsecond Scintillation-Induced Variability (MASIV) Survey
detected a drop in Interstellar Scintillation (ISS) for sources at redshifts z
> 2, indicating an apparent increase in angular diameter or a decrease in flux
density of the most compact components of these sources, relative to their
extended emission. This can result from intrinsic source size effects or
scatter broadening in the Intergalactic Medium (IGM), in excess of the expected
(1+z)^0.5 angular diameter scaling of brightness temperature limited sources
due to cosmological expansion. We report here 4.9 GHz and 8.4 GHz observations
and data analysis for a sample of 140 compact, flat-spectrum sources which may
allow us to determine the origin of this angular diameter-redshift relation by
exploiting their different wavelength dependences. In addition to using ISS as
a cosmological probe, the observations provide additional insight into source
morphologies and the characteristics of ISS. As in the MASIV Survey, the
variability of the sources is found to be significantly correlated with
line-of-sight H-alpha intensities, confirming its link with ISS. For 25
sources, time delays of about 0.15 to 3 days are observed between the
scintillation patterns at both frequencies, interpreted as being caused by a
shift in core positions when probed at different optical depths. Significant
correlation is found between ISS amplitudes and source spectral index; in
particular, a large drop in ISS amplitudes is observed at spectral indices of <
-0.4 confirming that steep spectrum sources scintillate less. We detect a
weakened redshift dependence of ISS at 8.4 GHz over that at 4.9 GHz, with the
mean variance at 4-day timescales reduced by a factor of 1.8 in the z > 2
sources relative to the z < 2 sources, as opposed to the factor of 3 decrease
observed at 4.9 GHz. This suggests scatter broadening in the IGM.Comment: 30 pages, 14 figures, accepted for publication in the Astronomical
Journa
Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group
Congenital nephrotic syndrome (CNS) is a heterogeneous group of disorders characterized by nephrotic-range proteinuria, hypoalbuminaemia and oedema, which manifest in utero or during the first 3 months of life. The main cause of CNS is genetic defects in podocytes; however, it can also be caused, in rare cases, by congenital infections or maternal allo-immune disease. Management of CNS is very challenging because patients are prone to severe complications, such as haemodynamic compromise, infections, thromboses, impaired growth and kidney failure. In this consensus statement, experts from the European Reference Network for Kidney Diseases (ERKNet) and the European Society for Paediatric Nephrology (ESPN) summarize the current evidence and present recommendations for the management of CNS, including the use of renin–angiotensin system inhibitors, diuretics, anticoagulation and infection prophylaxis. Therapeutic management should be adapted to the clinical severity of the condition with the aim of maintaining intravascular euvolaemia and adequate nutrition, while preventing complications and preserving central and peripheral vessels. We do not recommend performing routine early nephrectomies but suggest that they are considered in patients with severe complications despite optimal conservative treatment, and before transplantation in patients with persisting nephrotic syndrome and/or a WT1-dominant pathogenic variant
The extragalactic background and its fluctuations in the far-infrared wavelengths
A Cosmic Far-InfraRed Background (CFIRB) has long been predicted that would
traces the intial phases of galaxy formation. It has been first detected by
Puget et al.(1996) using COBE data and has been later confirmed by several
recent studies (Fixsen et al. 1998, Hauser et al. 1998, Lagache et al. 1999).
We will present a new determination of the CFIRB that uses for the first time,
in addition to COBE data, two independent gas tracers: the HI survey of
Leiden/Dwingeloo (hartmann, 1998) and the WHAM H survey (Reynolds et
al 1998). We will see that the CFIRB above 100 micron is now very well
constrained. The next step is to see if we can detect its fluctuations. To
search for the CFIRB fluctuations, we have used the FIRBACK observations.
FIRBACK is a deep cosmological survey conducted at 170 micron with ISOPHOT
(Dole et al., 2000). We show that the emission of unresolved extra-galactic
sources clearly dominates, at arcminute scales, the background fluctuations in
the lowest galactic emission regions. This is the first detection of the CFIRB
fluctuations.Comment: To appear in "ISO Surveys of a Dusty Universe", Workshop at Ringberg
Castle, November 8 - 12, 199
Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus
© 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Friedreich ataxia (FRDA) is caused by a homozygous GAA repeat expansion mutation within intron 1 of the FXN gene, which induces epigenetic changes and FXN gene silencing. Bisulfite sequencing studies have identified 5-methylcytosine (5 mC) DNA methylation as one of the epigenetic changes that may be involved in this process. However, analysis of samples by bisulfite sequencing is a time-consuming procedure. In addition, it has recently been shown that 5-hydroxymethylcytosine (5 hmC) is also present in mammalian DNA, and bisulfite sequencing cannot distinguish between 5 hmC and 5 mC.The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number 242193/EFACTS (CS), the Wellcome Trust [089757] (SA) and Ataxia UK (RMP) to MAP
Neutron Scattering study of Sr_2Cu_3O_4Cl_2
We report a neutron scattering study on the tetragonal compound
Sr_2Cu_3O_4Cl_2, which has two-dimensional (2D) interpenetrating Cu_I and
Cu_{II} subsystems, each forming a S=1/2 square lattice quantum Heisenberg
antiferromagnet (SLQHA). The mean-field ground state is degenerate, since the
inter-subsystem interactions are geometrically frustrated. Magnetic neutron
scattering experiments show that quantum fluctuations lift the degeneracy and
cause a 2D Ising ordering of the Cu_{II} subsystem. Due to quantum fluctuations
a dramatic increase of the Cu_I out-of-plane spin-wave gap is also observed.
The temperature dependence and the dispersion of the spin-wave energy are
quantitatively explained by spin-wave calculations which include quantum
fluctuations explicitly. The values for the nearest-neighbor superexchange
interactions between the Cu_I and Cu_{II} ions and between the Cu_{II} ions are
determined experimentally to be J_{I-II} = -10(2)meV and J_{II}= 10.5(5)meV,
respectively. Due to its small exchange interaction, J_{II}, the 2D dispersion
of the Cu_{II} SLQHA can be measured over the whole Brillouin zone with thermal
neutrons, and a novel dispersion at the zone boundary, predicted by theory, is
confirmed. The instantaneous magnetic correlation length of the Cu_{II} SLQHA
is obtained up to a very high temperature, T/J_{II}\approx 0.75. This result is
compared with several theoretical predictions as well as recent experiments on
the S=1/2 SLQHA.Comment: Figures and equations are rearrange
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