182 research outputs found
New Measurement of the 2S Hyperfine Interval in Atomic Hydrogen
An optical measurement of the 2S hyperfine interval in atomic hydrogen using
two-photon spectroscopy of the 1S-2S transition gives a value of 177 556
834.3(6.7) Hz. The uncertainty is
2.4 times smaller than achieved by our group in 2003 and more than 4 times
smaller than for any independent radio-frequency measurement. The specific
combination of the 2S and 1S hyperfine intervals predicted by QED theory
Hz is in good
agreement with the value of 48 923(54) Hz obtained from this experiment.Comment: 4 pages, 4 figure
New Limits to the Drift of Fundamental Constants from Laboratory Measurements
We have remeasured the absolute - transition frequency in atomic hydrogen. A comparison with the result of the previous
measurement performed in 1999 sets a limit of Hz for the drift of
with respect to the ground state hyperfine splitting in Cs. Combining this result with the recently published
optical transition frequency in Hg against and a
microwave Rb and Cs clock comparison, we deduce separate limits
on yr and the
fractional time variation of the ratio of Rb and Cs nuclear magnetic moments
equal to
yr. The latter provides information on the temporal behavior of the
constant of strong interaction.Comment: 4 pages, 3 figures, LaTe
Optical Clocks in Space
The performance of optical clocks has strongly progressed in recent years,
and accuracies and instabilities of 1 part in 10^18 are expected in the near
future. The operation of optical clocks in space provides new scientific and
technological opportunities. In particular, an earth-orbiting satellite
containing an ensemble of optical clocks would allow a precision measurement of
the gravitational redshift, navigation with improved precision, mapping of the
earth's gravitational potential by relativistic geodesy, and comparisons
between ground clocks.Comment: Proc. III International Conference on Particle and Fundamental
Physics in Space (SpacePart06), Beijing 19 - 21 April 2006, to appear in
Nucl. Phys.
F-18-fluorodeoxyglucose positron emission tomography-computed tomography for the diagnosis of Takayasu's arteritis in stroke: a case report
TĂ©cnicas de utilização de dicionĂĄrio como material didĂĄtico na aula de LE para fins especĂficos
Yersinia pestis Lineages in Mongolia
BACKGROUND: Whole genome sequencing allowed the development of a number of high resolution sequence based typing tools for Yersinia (Y.) pestis. The application of these methods on isolates from most known foci worldwide and in particular from China and the Former Soviet Union has dramatically improved our understanding of the population structure of this species. In the current view, Y. pestis including the non or moderate human pathogen Y. pestis subspecies microtus emerged from Yersinia pseudotuberculosis about 2,600 to 28,600 years ago in central Asia. The majority of central Asia natural foci have been investigated. However these investigations included only few strains from Mongolia. METHODOLOGY/PRINCIPAL FINDINGS: Clustered Regularly Interspaced Short Prokaryotic Repeats (CRISPR) analysis and Multiple-locus variable number of tandem repeats (VNTR) analysis (MLVA) with 25 loci was performed on 100 Y. pestis strains, isolated from 37 sampling areas in Mongolia. The resulting data were compared with previously published data from more than 500 plague strains, 130 of which had also been previously genotyped by single nucleotide polymorphism (SNP) analysis. The comparison revealed six main clusters including the three microtus biovars Ulegeica, Altaica, and Xilingolensis. The largest cluster comprises 78 isolates, with unique and new genotypes seen so far in Mongolia only. Typing of selected isolates by key SNPs was used to robustly assign the corresponding clusters to previously defined SNP branches. CONCLUSIONS/SIGNIFICANCE: We show that Mongolia hosts the most recent microtus clade (Ulegeica). Interestingly no representatives of the ancestral Y. pestis subspecies pestis nodes previously identified in North-western China were identified in this study. This observation suggests that the subsequent evolution steps within Y. pestis pestis did not occur in Mongolia. Rather, Mongolia was most likely re-colonized by more recent clades coming back from China contemporary of the black death pandemic, or more recently in the past 600 years
123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations
Reduced uptake of 123I- metaiodobenzylguanidine (MIBG) on cardiac gammagraphy and impaired odor identification are markers of neurodegenerative diseases with Lewy bodies (LB) as a pathological hallmark, such as idiopathic Parkinsonâs disease (IPD). LRRK2 patients present with a clinical syndrome indistinguishable from IPD, but LB have not been found in some cases. Patients with such mutations could behave differently than patients with IPD with respect to MIBG cardiac uptake and olfaction. We studied 14 LRRK2 patients, 14 IPD patients matched by age, gender, disease duration and severity, and 13 age and gender matched control subjects. Olfaction was analyzed through the University of Pennsylvania Smell Identification Test (UPSIT). MIBG cardiac uptake was evaluated through the H/M ratio. The late H/M was 1.44 ± 0.31 for LRRK2 patients, 1.19 ± 0.15 for PD patients, and 1.67 ± 0.16 for control subjects. LRRK2 patients presented lower but not statistically significant MIBG cardiac uptake than controls (p = 0.08) and significant higher uptake than PD patients (p = 0.04). UPSIT mean scores were 21.5 ± 7.3 for LRRK2 patients, 18.7 ± 6.2 for IPD patients and 29.7 ± 5.7 for control subjects. UPSIT score was lower in both LRRK2 and PD than in controls. In LRRK2 patients a positive correlation was found between myocardial MIBG uptake and UPSIT scores, (R = 0.801, p < 0.001). In LRRK2 patients, MIBG cardiac uptake was less impaired than in PD; a positive correlation between MIBG cardiac uptake and UPSIT scores was observed. As MIBG cardiac reduced uptake and impaired odor identification are markers of LB pathology, this findings may represent neuropathological heterogeneity among LRRK2 patients
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