Effects of Juvenile Idiopathic Arthritis on Kinematics and Kinetics of the Lower Extremities Call for Consequences in Physical Activities Recommendations

Juvenile idiopathic arthritis (JIA) patients (n = 36) with symmetrical polyarticular joint involvement of the lower extremities and healthy controls (n = 20) were compared concerning differences in kinematic, kinetic, and spatio-temporal parameters with 3D gait analysis. The aims of this study were to quantify the differences in gait between JIA patients and healthy controls and to provide data for more detailed sport activities recommendations. JIA-patients showed reduced walking speed and step length, strongly anterior tilted pelvis, reduced maximum hip extension, reduced knee extension during single support phase and reduced plantar flexion in push off. Additionally the roll-off procedure of the foot was slightly decelerated. The reduced push off motion in the ankle was confirmed by lower peaks in ankle moment and power. The gait of JIA-patients can be explained as a crouch-like gait with hyperflexion in hip and knee joints and less plantar flexion in the ankle. A preventive mobility workout would be recommendable to reduce these restrictions in the future. Advisable are sports with emphasis on extension in hip, knee, and ankle plantar flexion

Low-lying GT(+) strength in Co-64 studied via the Ni-64(d,He-2)Co-64 reaction

The Ni-64(d,He-2)Co-64 reaction was studied at the AGOR cyclotron of KVI, Groningen, with the Big-Bite Spectrometer and the EuroSuperNova detector using a 171-MeV deuteron beam. An energy resolution of about 110 keV was achieved. In addition to the J(pi) = 1(+) ground state, several other 1(+) states could be identified in Co-64 and the strengths of the corresponding Gamow-Teller transitions were determined. The obtained strength distribution was compared with theoretical predictions and former (n,p) experimental results and displayed a good agreement. Due to the good energy resolution, detailed spectroscopic information was obtained, which supplements the data base needed for network calculations for supernova scenarios

A tomographic study of the classical nova RR Pic

We present the results of spectrophotometric observations of the old nova RR Pic performed in two spectral ranges, one centered in the Ha line and other covering Hb and Hg spectral lines. From the Hb radial velocity study we found a primary radial semi-amplitude of K1 = 37(1) km/s and a systemic velocity of g = 1.8(2) km/s. With this new values a mass diagram is constructed, constraining the possible mass intervals for the system. The possible orbital inclination range was restricted using the fact that RR Pic presents shallow eclipses. A secondary mass range below the limit of a main sequence star filling its Roche lobe indicate an evolved companion. We also calculated the Ha, Hb, Hg, HeI 6678 and HeII 4686 Doppler tomograms. The most conspicuous differences are found between the HeI and HeII tomograms, the former has a ring shape, while the second is filled at low velocities, suggesting that the low velocity emission is not coming from the accretion disk. Radial emissivity profiles for these lines were also derived.Comment: 8 pages, 8 figures, accepted to appear in PAS

Differentiation of irradiation and cetuximab induced skin reactions in patients with locally advanced head and neck cancer undergoing radioimmunotherapy: the HICARE protocol (Head and neck cancer: ImmunoChemo and Radiotherapy with Erbitux) – a multicenter phase IV trial

BACKGROUND: In order to improve the clinical outcome of patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN) not being capable to receive platinum-based chemoradiation, radiotherapy can be intensified by addition of cetuximab, a monoclonal antibody that blocks the epidermal growth factor receptor (EGFR). The radioimmunotherapy with cetuximab is a feasible treatment option showing a favourable toxicity profile. The most frequent side effect of radiotherapy is radiation dermatitis, the most common side effect of treatment with cetuximab is acneiform rash. Incidence and severity of these frequent, often overlapping and sometimes limiting skin reactions, however, are not well explored. A clinical and molecular differentiation between radiogenic skin reactions and skin reactions caused by cetuximab which may correlate with outcome, have never been described before. METHODS/DESIGN: The HICARE study is a national, multicenter, prospective phase IV study exploring the different types of skin reactions that occur in patients with LASCCHN undergoing radioimmun(chemo)therapy with the EGFR inhibitor cetuximab. 500 patients with LASCCHN will be enrolled in 40 participating sites in Germany. Primary endpoint is the rate of radiation dermatitis NCI CTCAE grade 3 and 4 (v. 4.02). Radioimmunotherapy will be applied according to SmPC, i.e. cetuximab will be administered as loading dose and then weekly during the radiotherapy. Irradiation will be applied as intensity-modulated radiation therapy (IMRT) or 3D-dimensional radiation therapy. DISCUSSION: The HICARE trial is expected to be one of the largest trials ever conducted in head and neck cancer patients. The goal of the HICARE trial is to differentiate skin reactions caused by radiation from those caused by the monoclonal antibody cetuximab, to evaluate the incidence and severity of these skin reactions and to correlate them with outcome parameters. Besides, the translational research program will help to identify and confirm novel peripheral blood based molecular predictors and surrogates for treatment response and resistance. TRIAL REGISTRATION: Clinical Trial Identifier, NCT01553032 (clinicaltrials.gov) EudraCT number: 2010-019748-3

The Impact of Vulvar Lichen Sclerosus on Sexual Dysfunction

Background: Lichen sclerosus (LS) is a chronic inflammatory condition that is known to arise on the vulva. Many women with LS report vulvar pain, often affecting a patient's quality of life. In this study, the sexual function of LS patients, with and without pain, was compared to control populations. Materials and Methods: A case-control study to examine the relationship between LS and sexual dysfunction was conducted. A total of 335 women presenting to the gynecology clinic were included in the study: 197 women with biopsy confirmed LS were compared to two control groups (95 asymptomatic women were ?healthy? controls and 43 women had vulvovaginal candidiasis) on self-reported current health complaints, medical and surgical history and current symptoms such as pain and itching, type and frequency of sexual activity, and satisfaction with sexual activity. Results: Women with LS reported less frequent sexual activity than healthy controls (p=0.007) and Candida controls (p=0.04). Currently sexually active women with LS were significantly less likely to report vaginal intercourse (71.6%) than healthy controls (89.0%, p=0.003) or Candida controls (100%, p=0.0003), even though similar proportions of all three groups reported that vaginal intercourse was important. Satisfaction towards the quality of current sexual activity was significantly lower among women with LS compared with both the healthy and Candida control groups. 23.7% of women with LS reported that sexual activity was rarely or never satisfactory as compared with 0% of healthy controls (p<0.0001) and 6.5% of Candida controls (p=0.03). Conclusion: Women with LS have less frequent sexual activity and less satisfying sexual activity when compared with controls.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140128/1/jwh.2014.4805.pd

Dwarf Nova Oscillations and Quasi-Periodic Oscillations in Cataclysmic Variables: III. A New Kind of Dwarf Nova Oscillation, and Further Examples of the Similarities to X-Ray Binaries

We present measurements of the periods of Dwarf Nova Oscillations (DNOs) and Quasi-Periodic Oscillations (QPOs) in Cataclysmic Variable stars (CVs), many culled from published literature, but also others newly observed (in VZ Pyx, CR Boo, OY Car, Z Cha, AQ Eri, TU Men, HX Peg, CN Ori, V893 Sco, WX Hyi and EC2117-54). These provide data for 26 systems. We show that in general P_QPO ~ 15 P_DNO and that the correlation for CVs extends by three orders of magnitude lower in frequency the similar relationship found for X-Ray binaries. In addition, we have found that there is a second type of DNO, previously overlooked, which have periods ~ 4 times those of the regular DNOs (As well as those mined from publications, we have observed them in VW Hyi, OY Car, AQ Eri, V803 Cen, CR Boo, VZ Pyx, HX Peg and EC2117-54). Often both types of DNO coexist. Unlike the standard DNOs, the periods of the new type, which we refer to as longer period DNOs (lpDNOs), are relatively insensitive to accretion luminosity and can even appear in quiescence of dwarf novae. We interpret them as magnetically channelled accretion onto the differentially rotating main body of the white dwarf primary, rather than onto a rapidly slipping equatorial belt as in the case of the standard DNOs. This is supported by published measurements of v sin(i) for some of the primaries. Some similarities of the DNOs, lpDNOs and QPOs in CVs to the three types of QPO in X-Ray binaries (burst pulsation, high and low frequency QPOs) are noted.Comment: 19 pages, 30 figures. To appear in MNRA

Interparticle interactions:Energy potentials, energy transfer, and nanoscale mechanical motion in response to optical radiation

In the interactions between particles of material with slightly different electronic levels, unusually large shifts in the pair potential can result from photoexcitation, and on subsequent electronic excitation transfer. To elicit these phenomena, it is necessary to understand the fundamental differences between a variety of optical properties deriving from dispersion interactions, and processes such as resonance energy transfer that occur under laser irradiance. This helps dispel some confusion in the recent literature. By developing and interpreting the theory at a deeper level, one can anticipate that in suitable systems, light absorption and energy transfer will be accompanied by significant displacements in interparticle separation, leading to nanoscale mechanical motion

Swift J1753.5-0127: The Black Hole Candidate with the shortest orbital period

We present time-resolved photometry of the optical counterpart to the black hole candidate Swift J1753.5-0127, which has remained in the low/hard X-ray state and bright at optical/IR wavelengths since its discovery in 2005. At the time of our observations Swift J1753.5-0127 does not show a decay trend but remains stable at R=16.45 with a night to night variability of ~0.05 mag. The R-band light curves, taken from 2007 June 3 to August 31, are not sinusoidal, but exhibit a complex morphology with remarkable changes in shape and amplitude. The best period determination is 3.2443+-0.0010 hours. This photometric period is likely a superhump period, slightly larger than the orbital period. Therefore, Swift J1753.5-0127 is the black hole candidate with the shortest orbital period observed to date. Our estimation of the distance is comparable to values previously published and likely places Swift J1753.5-0127 in the Galactic halo.Comment: Accepted for publication in Ap