DISSIMILARITY: FEATURES OF WOMAN’S LANGUAGE CAUSED BY ALZHEIMER DISEASE IN ‘THE NOTEBOOK’

Abstrak Studi ini berkaitan dengan perbedaan cara bicara karakter wanita utama di film The Notebook (2004) yang menderita penyakit Alzheimer sehubungan dengan teori ciri bahasa perempuan yang diusulkan oleh Lakoff (1973). Tujuan utamanya adalah membandingkan kemampuan bahasa subjek, Allison Hamilton, sebelum dan setelah ia menderita penyakit Alzheimer. Setelah menganalisis data, dapat ditemukan bahwa hanya ada tujuh ciri yang digunakan oleh kedua Allison muda dan Allison tua di film The Notebook. Namun, apabila dikaitkan dengan kondisi Allison tua yang menderita penyakit Alzheimer, perbedaan dalam bagaimana menerapkan teori Lakoff ini sebagian besar terlihat pada tiga fitur yang dikenal sebagai hedging devices, intensifiers dan 'hypercorrect' grammar. Hal ini terjadi karena Allison cenderung menjadi karakter diri yang ragu dan tidak aman karena lupa akan sejarah hidupnya sendiri dan bahkan tidak mengenal orang-orang di sekelilingnya, terutama yang terdekat, suaminya. Selain itu, lingkungan dan kemampuannya dapat mempengaruhi Allison tua dalam menggunakan fitur bahasa perempuan. Kata Kunci: bahasa wanita, penyakit Alzheimer, kemampuan bahasa, perbedaan.   Abstract This study deals with the speech dissimilarity of main woman character who suffers from Alzheimer’s disease in The Notebook (2004) movie relating to the theory of women’s language features proposed by Lakoff (1973). The main purpose is comparing the language skill of the subject, Allison Hamilton, before and after suffering from Alzheimer’s disease. After examining the data, it can be found that there are only seven features used by both young and old Allison in The Notebook movie. However, if it is related to the condition of old Allison who suffers from Alzheimer’s disease, the differences in how to apply Lakoff’s theory are mostly visible in three features which are known as hedging devices, intensifiers and ‘hypercorrect’ grammar. This occurs because Allison tends to be a self-doubting character who forgets her own history and, even, does not recognize people around her, especially the closest one, her husband. Besides her surroundings and ability may influence old Allison in using the features of women’s language. Keywords: women’s language, Alzheimer’s disease, language skill, dissimilarity. &nbsp

Insersi Gen Lisozim pada Ikan Patin Siam Pangasianodon Hypophthalmus (Sauvage, 1878) untuk Membentuk Galur Tahan Penyakit [Lysozyme Gene Insertion In Striped Catfish Pangasianodon Hypophthalmus (Sauvage, 1878) To Generate Desease Resistence Breeds Line]

Serangan penyakit bakterial pada ikan patin telah banyak merugikan para pembudi daya ikan patin terutama pada seg-men perbenihan hingga ukuran siap tebar. Oleh karena itu diperlukan teknologi yang mampu menghasilkan ikan patin yang tahan penyakit. Berkaitan dengan hal itu, salah satu enzim antimikroba yaitu lisozim yang memainkan peranan penting dalam imunitas bawaan dapat diintroduksikan ke dalam genom ikan. Penelitian ini bertujuan untuk mengevalu-asi keberhasilan insersi gen lisozim ke dalam genom ikan patin siam sebagai galur ikan patin tahan penyakit. Transfer gen dilakukan dengan menggunakan teknik elektroporasi pada spermatozoa ikan patin siam. Elektroporasi dilakukan dengan konstruksi gen lisozim berupa plasmid DNA dosis 100 ^g.ml-1 dengan voltase 125 V. cm-1, panjang kejutan 30 milidetik dengan interval kejutan 0.1 milidetik dan jumlah kejutan lima kali. Spermatozoa hasil elektroporasi digunakan untuk membuahi telur. Pengujian keberhasilan insersi gen lisozim dilakukan pada tahap embrio larva, dan pada benih. Hasil pengujian, baik pada tingkat DNA maupun pada tingkat RNA dari sampel spermatozoa dan larva (whole cell), memperlihatkan hasil yang positif. Individu ikan patin yang membawa gen lisozim dan telah terintegrasi ke dalam ge-nomnya akan digunakan sebagai kandidat dalam pembentukan galur ikan patin tahan penyakit

DISSIMILARITY: FEATURES OF WOMAN’S LANGUAGE CAUSED BY ALZHEIMER DISEASE IN ‘THE NOTEBOOK’

Abstrak Studi ini berkaitan dengan perbedaan cara bicara karakter wanita utama di film The Notebook (2004) yang menderita penyakit Alzheimer sehubungan dengan teori ciri bahasa perempuan yang diusulkan oleh Lakoff (1973). Tujuan utamanya adalah membandingkan kemampuan bahasa subjek, Allison Hamilton, sebelum dan setelah ia menderita penyakit Alzheimer. Setelah menganalisis data, dapat ditemukan bahwa hanya ada tujuh ciri yang digunakan oleh kedua Allison muda dan Allison tua di film The Notebook. Namun, apabila dikaitkan dengan kondisi Allison tua yang menderita penyakit Alzheimer, perbedaan dalam bagaimana menerapkan teori Lakoff ini sebagian besar terlihat pada tiga fitur yang dikenal sebagai hedging devices, intensifiers dan 'hypercorrect' grammar. Hal ini terjadi karena Allison cenderung menjadi karakter diri yang ragu dan tidak aman karena lupa akan sejarah hidupnya sendiri dan bahkan tidak mengenal orang-orang di sekelilingnya, terutama yang terdekat, suaminya. Selain itu, lingkungan dan kemampuannya dapat mempengaruhi Allison tua dalam menggunakan fitur bahasa perempuan. Kata Kunci: bahasa wanita, penyakit Alzheimer, kemampuan bahasa, perbedaan.   Abstract This study deals with the speech dissimilarity of main woman character who suffers from Alzheimer’s disease in The Notebook (2004) movie relating to the theory of women’s language features proposed by Lakoff (1973). The main purpose is comparing the language skill of the subject, Allison Hamilton, before and after suffering from Alzheimer’s disease. After examining the data, it can be found that there are only seven features used by both young and old Allison in The Notebook movie. However, if it is related to the condition of old Allison who suffers from Alzheimer’s disease, the differences in how to apply Lakoff’s theory are mostly visible in three features which are known as hedging devices, intensifiers and ‘hypercorrect’ grammar. This occurs because Allison tends to be a self-doubting character who forgets her own history and, even, does not recognize people around her, especially the closest one, her husband. Besides her surroundings and ability may influence old Allison in using the features of women’s language. Keywords: women’s language, Alzheimer’s disease, language skill, dissimilarity. &nbsp

Development of mathematical cost model for room temperature end-milling of AISI D2 tool steel

In this research paper, reliable mathematical model for estimating the cost of room temperature end-milling of AISI D2 tool steel using TiAlN coated carbide tool inserts is developed. Initially, the different components of machining cost were identified, followed by establishment of equations to determine their values. Then, the required experimental and non-experimental data were collected and the bottom-up approach was adopted for evaluating the cost of machining corresponding to each of fifteen experimental runs. The Response Surface Methodology (RSM) was used to develop the model in which the cost of machining is given as a function of the machining parameters: cutting speed, feed per tooth, and depth of cut, and expressed in RM per cm3. ANOVA output was utilized to check the adequacy of the developed model. The developed model was found to be statistically adequate and this was confirmed by the small prediction errors made by the mode

Development of mathematical cost model for preheated end-milling of AISI D2 tool steel

Mohamed Elhadie1, A. N. Mustafizul Karim1, A. K. M. Nurul Amin1 Department of Manufacturing and Materials Engineering International Islamic University Malaysia, Gombak, Kuala Lumpur 53100, Malaysia M. A. Lajis2 Faculty of Mechanical and Manufacturing Engineering Universiti Tun Hussein Onn Malaysia, Batu Pahat, Johor Bahru 86400, Malaysia Abstract In this research paper, reliable mathematical model for estimating the cost of preheated end-milling of AISI D2 tool steel using TiAlN coated carbide tool inserts is developed. Initially, the different components of machining cost were identified, followed by establishment of equations to determine their values. Then, the required experimental and non-experimental data were collected and the bottom-up approach was adopted for evaluating the cost of machining corresponding to each of fifteen experimental runs. The Response Surface Methodology (RSM) was used to develop the model in which the cost of machining is given as a function of the machining parameters; cutting speed, feed per tooth, and preheating temperature, and expressed in RM per cm3. ANOVA output was utilized to check the adequacy of the developed model. The developed model was found to be statistically adequate and this was confirmed by the small prediction errors made by the model. Keywords: machinin

Pendampingan Sekolah Dasar Negeri 4 Kupang, Jabon dalam Menghadapi New Normal

Kejadian pandemi Corona menyebabkan perubahan seluruh aspek kehidupan di masyarakat termasuk di dunia pendidikan. Pemerintah telah memutuskan adanya kehidupan normal yang mengharuskan setiap orang terbiasa untuk hidup berdampingan dengan wabah virus Corona. Tujuan dari kegiatan ini adalah untuk memberikan bimbingan dan dukungan fasilitas di SDN 4 Kupang, Jabon, Sidoarjo dalam rangka menghadapi kehidupan dunia normal (new normal) akibat adanya pandemi covid 19. Metode yang digunakan adalah Pembimbingan dan pelatihan kepada guru dan siswa. Peserta dari kegiatan ini meliputi guru SDN 4 Kupang (6 Orang) dan seluruh siswa SD N dari kelas 1 sampai kelas 6 yang berjumlah 19 orang. Hasil dari kegiatan ini adalah ditemukan kendala pada sekolah guna menghadapi kehidupan baru diantaranya meliputi kesulitan menyediakan fasilitas pendukung wajib new normal serta kesadaran siswa yang masih rendah untuk berkegiatan sesuai dengan norma kehidupan baru. Luaran dari kegiatan ini adalah terselesaikannya kendala sekolah di dalam menghadapi kehidupan yang normal dan meningkatnya wawasan guru dan siswa wabah covid 19

Observations on the Cerebral Effects of Refractory Intracranial Hypertension After Severe Traumatic Brain Injury

Funder: Woolf Fisher TrustAbstract: Background: Raised intracranial pressure (ICP) is a prominent cause of morbidity and mortality after severe traumatic brain injury (TBI). However, in the clinical setting, little is known about the cerebral physiological response to severe and prolonged increases in ICP. Methods: Thirty-three severe TBI patients from a single center who developed severe refractory intracranial hypertension (ICP > 40 mm Hg for longer than 1 h) with ICP, arterial blood pressure, and brain tissue oxygenation (PBTO2) monitoring (subcohort, n = 9) were selected for retrospective review. Secondary parameters reflecting autoregulation (including pressure reactivity index—PRx, which was available in 24 cases), cerebrospinal compensatory reserve (RAP), and ICP pulse amplitude were calculated. Results: PRx deteriorated from 0.06 ± 0.26 a.u. at baseline levels of ICP to 0.57 ± 0.24 a.u. (p 50 mm Hg). In 4 cases, PRx was impaired (> 0.25 a.u.) before ICP was raised above 25 mm Hg. Concurrently, PBTO2 decreased from 27.3 ± 7.32 mm Hg at baseline ICP to 12.68 ± 7.09 mm Hg at high levels of ICP (p < 0.001). The pulse amplitude of the ICP waveform increased with increasing ICP but showed an ‘upper breakpoint’—whereby further increases in ICP lead to decreases in pulse amplitude—in 6 out of the 33 patients. Discussion: Severe intracranial hypertension after TBI leads to decreased brain oxygenation, impaired pressure reactivity, and changes in the pulse amplitude of ICP. Impaired pressure reactivity may denote increased risk of developing refractory intracranial hypertension in some patients