Beyond crime: justice and sustainability in the classroom and community

Criminology and criminal justice are not perhaps the most immediately obvious disciplinary hosts for embedding ESD. Yet, specific theoretical approaches (critical criminology, green criminology, zemiology and public criminology) within them illustrate clear overlaps with the sustainable development agenda. Perhaps the most explicit connections between criminology and sustainability are made via the concept of justice. Agyeman and colleagues (2003: 3) note how “justice and sustainability are intimately linked and mutually interdependent, certainly at the problem level and increasingly at the solution level.” Issues of inequality and injustice (and crucially, ways of addressing them) can be linked to the four areas of environmental, social, economic and cultural sustainability (UNESCO, 2005). The paper reflects on how such considerations have been introduced into criminology and criminal Justice curriculum by way of a new and innovative module ‘Criminology for a Just Society’. The pedagogical approach adopted is explicitly interdisciplinary and student-centred. The learning, teaching and assessment strategies of the module were developed in close collaboration with the students, facilitating a strong sense of commitment and ownership. Service learning through volunteering placements and assessment embedding critical reflection and knowledge exchange have helped facilitate transformational learning for all involved. The paper reflects on the student and staff experiences from the first year of ‘Criminology for a Just Society’, focusing on the benefits and challenges of learning beyond familiar disciplinary and classroom contexts, and the more enriched and connected understanding of criminology and sustainability developed as a result

NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease

The NMDA receptor is a Ca 2+-permeant glutamate receptor which plays key roles in health and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A and 2B are predominant in the forebrain. Moreover, the relative contribution of 2A vs. 2B is controlled both developmentally and in an activity-dependent manner. The GluN2 subtype influences the biophysical properties of the receptor through difference in their N-terminal extracellular domain and transmembrane regions, but they also have large cytoplasmic Carboxyl (C)-terminal domains (CTDs) which have diverged substantially during evolution. While the CTD identity does not influence NMDAR subunit specific channel properties, it determines the nature of CTD-associated signalling molecules and has been implicated in mediating the control of subunit composition (2A vs. 2B) at the synapse. Historically, much of the research into the differential function of GluN2 CTDs has been conducted in vitro by over-expressing mutant subunits, but more recently, the generation of knock-in (KI) mouse models have allowed CTD function to be probed in vivo and in ex vivo systems without heterologous expression of GluN2 mutants. In some instances, findings involving KI mice have been in disagreement with models that were proposed based on earlier approaches. This review will examine the current research with the aim of addressing these controversies and how methodology may contribute to differences between studies. We will also discuss the outstanding questions regarding the role of GluN2 CTD sequences in regulating NMDAR subunit composition, as well as their relevance to neurodegenerative disease and neurodevelopmental disorders. </p

UKAIRO: internet-scale bandwidth detouring

The performance of content distribution on the Internet is crucial for many services. While popular content can be delivered efficiently to users by caching it using content delivery networks, the distribution of less popular content is often constrained by the bandwidth of the Internet path between the content server and the client. Neither can influence the selected path and therefore clients may have to download content along a path that is congested or has limited capacity. We describe UKAIRO, a system that reduces Internet download times by using detour paths with higher TCP throughput. UKAIRO first discovers detour paths among an overlay network of potential detour hosts and then transparently diverts HTTP connections via these hosts to improve the throughput of clients downloading from content servers. Our evaluation shows that by performing infrequent bandwidth measurements between 50 randomly selected PlanetLab hosts, UKAIRO can identify and exploit potential detour paths that increase the median bandwidth to public Internet web servers by up to 80%

Neurofilament Light in CSF and Plasma Is a Marker of Neuronal Damage in HTLV-1-Associated Myelopathy and Correlates With Neuroinflammation

BACKGROUND AND OBJECTIVES: To evaluate the usefulness of CSF and plasma neurofilament light (Nf-L) as a biomarker for human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy (HAM). METHODS: Nf-L, CXCL10, and neopterin were measured by ELISA in 83 CSF samples obtained from 49 individuals living with HTLV-1/2. Plasma Nf-L was also measured by single molecule array. Results were correlated with duration of disease, age, mobility, CSF cell counts, CSF protein, and HTLV-1 proviral load. RESULTS: Nf-L was detected in all CSF samples (median [range] = 575 [791.8-2,349] pg/mL) and positively correlated with markers of inflammation (CXCL10 (r = 0.733), neopterin (r = 0.499), cell count (r = 0.403), and protein levels (r = 0.693) in CSF; p < 0.0015). There was an inverse correlation between Nf-L and duration of disease (r = -0.584, p < 0.0001). Wheelchair-dependent patients had high concentrations of markers of inflammation and neuronal damage. Concentrations of CXCL10, neopterin, and Nf-L remained elevated in follow-up samples (mean follow-up 5.2 years). Nf-L in plasma correlated with concentration of Nf-L, neopterin, CXCL10, and protein in CSF. CONCLUSIONS: Nf-L in plasma and CSF has potential to be used as a biomarker of disease activity in HAM. Neuronal damage seems to be more intense early in disease but persists long term. Wheelchair-dependent patients have ongoing neuroinflammation

A review of mission planning systems

A general definition of Mission Planning is given. The definition covers the full scope of an end-to-end mission planning system. Noting the mission-specific nature of most mission planning systems, a classification of autonomous spacecraft missions is made into Observatory, Survey, multi-instrument science, and Telecommunications missions. The mission planning approach for one mission in each category is examined critically. The following missions were chosen: ISO (Infrared Space Observatory); ERS-1 (European Remote Sensing Satellite); and Eureca (European Retrievable Carrier). The paper gives a summary of lessons learned from these missions suggesting improvements in areas such as requirements analysis, testing, user interfacing, rules, and constraints handling. The paper will also examine commonalities in functions, which could constitute a basis for identification of generic mission planning support tools

Purely gravito-magnetic vacuum space-times

It is shown that there are no vacuum space-times (with or without cosmological constant) for which the Weyl-tensor is purely gravito-magnetic with respect to a normal and timelike congruence of observers.Comment: 4 page

Intensive care utilisation and outcomes after high-risk surgery in Scotland: a population based cohort study.

Chief Scientist’s Office Scotland (grant no. CHZ/821/4)

A mixed methods comparative evaluation of a low cost otoscope (Arclight) with a traditional device in twenty-one clinicians

According to the World Health Organisation estimate, the global burden of illness from chronic ear infection affects about 4% of the world population (up to 330 million) with ear discharge and 60% of whom (up to 200 million) suffer from significant hearing impairment.1 Alarmingly, over 90% of the burden of chronic ear infections is borne by low‐ and middle‐income countries (LMICs).PostprintPeer reviewe