857 research outputs found
Dynamics of metal clusters in rare gas clusters
We investigate the dynamics of Na clusters embedded in Ar matrices. We use a
hierarchical approach, accounting microscopically for the cluster's degrees of
freedom and more coarsely for the matrix. The dynamical polarizability of the
Ar atoms and the strong Pauli-repulsion exerted by the Ar-electrons are taken
into account. We discuss the impact of the matrix on the cluster gross
properties and on its optical response. We then consider a realistic case of
irradiation by a moderately intense laser and discuss the impact of the matrix
on the hindrance of the explosion, as well as a possible pump probe scenario
for analyzing dynamical responses.Comment: Proceedings of the 30th International Workshop on Condensed Matter
Theories, Dresden, June 05 - 10, 2006, World Scientific. 3 figure
Digitoxin metabolism by rat liver microsomes.
Background: Malnutrition among hospitalized patients increases length of stay (LOS) and carries extra hospitalization costs.
Objective: To review the impact of malnutrition on hospital LOS and costs in Europe.
Methods: PubMed and Google Scholar search. All articles from January 2004 until November 2014 were identified. Reference lists of relevant articles were also manually searched.
Results: Ten studies on LOS and nine studies on costs were reviewed. The methods used to assess
malnutrition and to calculate costs differed considerably between studies. Malnutrition led to an
increased LOS ranging from 2.4 to 7.2 days. Among hospitalized patients, malnutrition led to an additional individual cost ranging between 1640 V and 5829 V. At the national level, the costs of malnutrition ranged between 32.8 million V and 1.2 billion V. Expressed as percentage of national health expenditures, the values ranged between 2.1% and 10%.
Conclusions: In Europe, malnutrition leads to an increase in LOS and in hospital costs, both at the individual and the national level. Standardization of methods and results reported is needed to adequately
compare results between countries.
© 2015 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights
reserved
Quantitative Assessment of Robotic Swarm Coverage
This paper studies a generally applicable, sensitive, and intuitive error
metric for the assessment of robotic swarm density controller performance.
Inspired by vortex blob numerical methods, it overcomes the shortcomings of a
common strategy based on discretization, and unifies other continuous notions
of coverage. We present two benchmarks against which to compare the error
metric value of a given swarm configuration: non-trivial bounds on the error
metric, and the probability density function of the error metric when robot
positions are sampled at random from the target swarm distribution. We give
rigorous results that this probability density function of the error metric
obeys a central limit theorem, allowing for more efficient numerical
approximation. For both of these benchmarks, we present supporting theory,
computation methodology, examples, and MATLAB implementation code.Comment: Proceedings of the 15th International Conference on Informatics in
Control, Automation and Robotics (ICINCO), Porto, Portugal, 29--31 July 2018.
11 pages, 4 figure
The effects of swing-leg retraction on running performance: analysis, simulation, and experiment
Using simple running models, researchers have argued that swing-leg retraction can improve running robot performance. In this paper, we investigate whether this holds for a more realistic simulation model validated against a physical running robot. We find that swing-leg retraction can improve stability and disturbance rejection. Alternatively, swing-leg retraction can simultaneously reduce touchdown forces, slipping likelihood, and impact energy losses. Surprisingly, swing-leg retraction barely affected net energetic efficiency. The retraction rates at which these effects are the greatest are strongly model-dependent, suggesting that robot designers cannot always rely on simplified models to accurately predict such complex behaviors
Chronic Chagas disease: from basics to laboratory medicine
Chagas disease, caused by Trypanosoma cruzi infection, is ranked as the most serious parasitic disease in Latin America and has huge potential to become a worldwide problem, due to increasing migration, and international tourism, as well as infectant transfer by blood contact and transfusion, intrauterine transfer, and organ transplantation. Nearly 30% of chronically-infected patients become symptomatic, often with a latency of 10-30 years, developing life-threatening complications. Of those, nearly 90% develop Chagas heart disease, while the others manifest gastrointestinal disease and neuronal disorders. Besides interrupting the infection cycle and chemotherapeutic infectant elimination, starting therapy early in symptomatic patients is important for counteracting the disease. This would be essentially supported by optimized patient management, involving risk assessment, early diagnosis and monitoring of the disease and its treatment. From economic and logistic viewpoints, the tools of laboratory medicine should be especially able to guarantee this. After summarizing the basics of chronic Chagas disease, such as the epidemiological data, the pathogenetic mechanisms thought to drive symptomatic Chagas disease and also treatment options, we present tools of laboratory medicine that address patient diagnosis, risk assessment for becoming symptomatic and guidance, focusing on autoantibody estimation for risk assessment and heart marker measurement for patient guidance. In addition, increases in levels of inflammation and oxidative stress markers in chronic Chagas disease are discussed
Mechanism of DNA cleavage by the DNA/RNA-non-specific Anabaena sp. PCC 7120 endonuclease NucA and its inhibition by NuiA
A structural model of the DNA/RNA non-specific endonuclease NucA from Anabaena sp. PCC7120 that has been obtained on the basis of the three-dimensional structure of the related Serratia nuclease, suggests that the overall architecture of the active site including amino acid residues H124, N155 and E163 (corresponding to H89, N119 and E127 in Serratia nuclease) is similar in both nucleases. Substitution of these residues by alanine leads to a large reduction in activity (<0.1%), similarly as observed for Serratia nuclease demonstrating that both enzymes share a similar mechanism of catalysis with differences only in detail. NucA is inhibited by its specific polypeptide inhibitor with a K1 value in the subpicomolar range, while the related Serratia nuclease at nanomolar concentrations is only inhibited at an approximately 1000-fold molar excess of NuiA. The artificial chromophoric substrate deoxythymidine 3',5'-bis-(p-nitrophenyl phosphate) is cleaved by NucA as well as by Serratia nuclease. Cleavage of this analogue by NucA, however, is not inhibited by NuiA, suggesting that small molecules gain access to the active site of NucA in the enzyme-inhibitor complex under conditions where cleavage of DNA substrates is completely inhibited. The active site residue E163 seems to be the main target amino acid for inhibition of NucA by NuiA, but R93, R122 and R167 (corresponding to K55, R87, R131 in Serratia nuclease) are also involved in the NucA/NuiA interaction. NuiA deletion mutants show that the structural integrity of the N and C-terminal region of the inhibitor is important for complex formation with NucA and inhibition of nuclease activity. Based on these results a mechanism of DNA cleavage by NucA and its inhibition by NuiA is proposed. (C) 2000 Academic Press
Rodenticide residues in non-target small mammal species and their occurrence in owl pellets
OBJECTIVES: Distinguishing the patterns of autoantibodies (AAB) against G-protein-coupled receptors in Chagas' cardiomyopathy and megacolon and the discovery of such a pattern in patients who are as yet asymptomatic could help to identify patients at high risk of developing the life-threatening complications of Chagas' disease. BACKGROUND: Such AAB against receptors as beta 1 (beta1-AAB), beta 2 (beta2-AAB), and muscarinergic 2 (M2-AAB) are thought to be involved in the pathogenesis of Chagas' cardiomyopathy and megacolon, the predominant manifestations of Chagas' disease, which is the most serious parasitic disease in Latin America. METHODS: Beta1-AAB, beta2-AAB, and M2-AAB were measured in the serum of asymptomatic Chagas' patients and in those with cardiomyopathy and/or megacolon. RESULTS: Nearly all Chagas' patients with cardiomyopathy and/or megacolon had AAB. Predominance of beta1-AAB combined with M2-AAB in Chagas' cardiomyopathy and beta2-AAB with M2-AAB in megacolon was found. Such patterns were also found in 34% of the asymptomatic patients, of whom 85% possessed a beta1-AAB level typical for Chagas' cardiomyopathy. CONCLUSIONS: The percentage of asymptomatic Chagas' patients who had a specific AAB pattern and had a beta1-AAB level above a defined cutoff point mirrors very well the epidemiological situation, which showed that clinical manifestations develop in nearly 30% of Chagas' patients and cardiomyopathy in nearly 90% of them. We hypothesize that beta1-, beta2-, and M2-AAB measurement might be a useful tool for risk assessment in the indeterminate state of Chagas' disease to select patients for earlier involvement in care programs. However, prospective studies are needed to further evaluate this hypothesis
Geometric magic numbers of sodium clusters: Interpretation of the melting behaviour
Putative global minima of sodium clusters with up to 380 atoms have been
located for two model interatomic potentials. Structures based upon the Mackay
icosahedra predominate for both potentials, and the magic numbers for the
Murrell-Mottram model show excellent agreement with the sizes at which maxima
in the latent heat and entropy change at melting have been found in experiment.Comment: 4 pages, 2 figure
Ultraviolet photoelectron spectroscopy of Nb − 4 to Nb − 200
Abstract. We present UV (hν = 6.42 eV) photoelectron spectra of niobium cluster anions Nb − n in the size range from n = 4 to n = 200. The spectra exhibit a variety of patterns, which can be related to the geometrical structures of the clusters. The charging energies of the larger clusters are in very good agreement with the metallic sphere model. Nevertheless a strong size dependence of the work function is observed, which underlines the special properties of this transition metal. PACS. 33.60.Cv Ultraviolet and vacuum ultraviolet photoelectron spectra -36.40.Cg Electronic and magnetic properties of clusters -73.22.-f Electronic structure of nanoscale materials
Anharmonic properties of double giant dipole resonance
A systematic microscopic study of the anharmonic properties of the double
giant dipole resonance (DGDR) has been carried out, for the first time, for
nuclei with mass number spanning the whole mass table. It is concluded that
the corrections of the energy centroid of the and
components of the DGDR from its harmonic limit are negative, have a value of
the order of few hundred keV and follow an dependence.Comment: 4 pages, 2 figure
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