Risk Factors of Drug Interaction between Warfarin and Nonsteroidal Anti-Inflammatory Drugs in Practical Setting

Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to interact with the oral anticoagulant warfarin and can cause a serious bleeding complication. In this study, we evaluated the risk factors for international normalized ratio (INR) increase, which is a surrogate marker of bleeding, after addition of an NSAID in a total of 98 patients who used warfarin. Patient age, sex, body mass index, maintenance warfarin dose, baseline INR, coadministered medications, underlying diseases, and liver and kidney functions were evaluated for possible risk factors with INR increase ≥15.0% as the primary end-point. Of the 98 patients, 39 (39.8%) showed an INR elevation of ≥15.0% after adding a NSAID to warfarin therapy. Multivariate analysis showed that high maintenance dose (>40 mg/week) of warfarin (P=0.001), the presence of coadministered medications (P=0.024), the use of meloxicam (P=0.025) and low baseline INR value (P=0.03) were the risk factors for INR increase in respect to NSAID-warfarin interaction. In conclusion, special caution is required when an NSAID is administered to warfarin users if patients are taking warfarin >40 mg/week and other medications interacting with warfarin

Ariadne : Drama dalam tiga babak.

Yogyakarta64 p.; 21 cm

Lezen achter de letters

In de bundel Lezen achter de letters is een ruime keuze te vinden uit de essays over literatuur die Hella Haasse vanaf 1965 publiceerde. In die productie van meer dan veertig jaar laat zij haar schrijversblik gaan over het werk van bijna alle grote collega-auteurs van haar tijd, zoals W.F. Hermans, S. Vestdijk en Jan Wolkers. In haar analyses combineert Haasse een uiterst zorgvuldige lectuur met het vermogen om in de door haar naar voren gehaalde literaire werken een persoonlijke visie te projecteren

Urug

Adaptált digitalizált tananyag. Az ELTE Fogyatékosügyi Központja a fogyatékossággal élő hallgatók megsegítése céljából tananyagokat adaptál. A tananyag akadálymentes, adaptált változata az arra jogosult (a fogyatékosügyi koordinátoroknál regisztrált) hallgatók számára érhető el