AMI observations of 10 CLASH galaxy clusters: SZ and X-ray data used together to determine cluster dynamical states

© 2016 The Authors. Published by Oxford University Press on behalf of The Royal Astronomical Society.Using Arcminute Microkelvin Imager (AMI) Sunyaev-Zel'dovich (SZ) observations towards 10 CLASH (Cluster Lensing and Supernova Survey with Hubble) clusters, we investigate the influence of cluster mergers on observational galaxy cluster studies. Although selected to be largely relaxed, there is disagreement in the literature on the dynamical states of CLASH sample members. We analyse ourAMIdata in a fully Bayesianway to produce estimated cluster parameters and consider the intrinsic correlations in our Navarro, Frenk and White/generalized Navarro, Frenk and White-based model. Varying pressure profile shape parameters, illustrating an influence of mergers on scaling relations, induces small deviations from the canonical selfsimilar predictions - in agreement with simulations of Poole et al. (2007) who found that merger activity causes only small scatter perpendicular to the relations. We demonstrate this effect observationally using the different dependences of SZ and X-ray signals to ne that cause different sensitivities to the shocking and/or fractionation produced by mergers. Plotting YX-Mgas relations (where YX = MgasT) derived from AMI SZ and from Chandra X-ray gives ratios of AMI and Chandra YX and Mgas estimates that indicate movement of clusters along the scaling relation, as predicted by Poole et al. (2007). Clusters that have moved most along the relation have the most discrepant TSZ and TX estimates: all the other clusters (apart from one) have SZ and X-ray estimates of Mgas, T and YX that agree within r500. We use SZ versus X-ray discrepancies in conjunction with Chandra maps and TX profiles, making comparisons with simulated cluster merger maps in Poole et al. (2006) to identify disturbed members of our sample and estimate merger stages.We thank the staff of the Mullard Radio Astronomy Observatory for their invaluable assistance in the commissioning and operation of AMI, which is supported by Cambridge University. WJH and CR are grateful for the support of STFC Studentships. CR also acknowledges the support of Cambridge University. MO and YCP acknowledge support from Research Fellowships from Sidney Sussex College and Trinity College, Cambridge, respectively. We thank Arif Babul for his assistance in accessing the Poole et al. online materials. Much of this work was undertaken on the COSMOS Shared Memory system at DAMTP, Cambridge University, operated on behalf of the STFC DiRAC HPC Facility. This equipment is funded by BIS National E-infrastructure capital grant ST/J005673/1 and STFC grants ST/H008586/1, ST/K00333X/1

The impact of patient self assessment of deformity on HRQL in adults with scoliosis

Background: Body image and HRQL are significant issues for patients with scoliosis due to cosmetic deformity, physical and psychological symptoms, and treatment factors. A selective review of scoliosis literature revealed that self report measures of body image and HRQL share unreliable correlations with radiographic measures and clinician recommendations for surgery. However, current body image and HRQL measures do not indicate which aspects of scoliosis deformity are the most distressing for patients. The WRVAS is an instrument designed to evaluate patient self assessment of deformity, and may show some promise in identifying aspects of deformity most troubling to patients. Previous research on adolescents with scoliosis supports the use of the WRVAS as a clinical tool, as the instrument shares strong correlations with radiographic measures and quality of life instruments. There has been limited use of this instrument on adult populations. Methods: The WRVAS and the SF-36v2, a HRQL measure, were administered to 71 adults with scoliosis, along with a form to report age and gender. Preliminary validation analyses were performed on the WRVAS (floor and ceiling effects, internal consistency and collinearity, correlations with the SF-36v2, and multiple regression with the WRVAS total score as the predictor, and SF-36v2 scores as outcomes). Results: The psychometric properties of the WRVAS were acceptable. Older participants perceived their deformities as more severe than younger participants. More severe deformities were associated with lower scores on the Physical Component Summary Score of the SF-36v2. Total WRVAS score also predicted Physical Component Summary scores. Conclusion: The results of the current study indicate that the WRVAS is a reliable tool to use with adult patients, and that patient self assessment of deformity shared a relationship with physical rather than psychological aspects of HRQL. The current and previous studies concur that revision of the WRVAS is necessary to more accurately represent the diversity of scoliosis deformities. Ability to identify disturbing aspects of deformity could potentially be improved by evaluating each WRVAS items against indicators of pain, physical/psychosocial function, and self image from previous measures such as the SRS, SF-36 or BSSQ-deformity

Spine Calcium Transients Induced by Synaptically-Evoked Action Potentials Can Predict Synapse Location and Establish Synaptic Democracy

CA1 pyramidal neurons receive hundreds of synaptic inputs at different distances from the soma. Distance-dependent synaptic scaling enables distal and proximal synapses to influence the somatic membrane equally, a phenomenon called “synaptic democracy”. How this is established is unclear. The backpropagating action potential (BAP) is hypothesised to provide distance-dependent information to synapses, allowing synaptic strengths to scale accordingly. Experimental measurements show that a BAP evoked by current injection at the soma causes calcium currents in the apical shaft whose amplitudes decay with distance from the soma. However, in vivo action potentials are not induced by somatic current injection but by synaptic inputs along the dendrites, which creates a different excitable state of the dendrites. Due to technical limitations, it is not possible to study experimentally whether distance information can also be provided by synaptically-evoked BAPs. Therefore we adapted a realistic morphological and electrophysiological model to measure BAP-induced voltage and calcium signals in spines after Schaffer collateral synapse stimulation. We show that peak calcium concentration is highly correlated with soma-synapse distance under a number of physiologically-realistic suprathreshold stimulation regimes and for a range of dendritic morphologies. Peak calcium levels also predicted the attenuation of the EPSP across the dendritic tree. Furthermore, we show that peak calcium can be used to set up a synaptic democracy in a homeostatic manner, whereby synapses regulate their synaptic strength on the basis of the difference between peak calcium and a uniform target value. We conclude that information derived from synaptically-generated BAPs can indicate synapse location and can subsequently be utilised to implement a synaptic democracy

Active dendrites enhance neuronal dynamic range

Since the first experimental evidences of active conductances in dendrites, most neurons have been shown to exhibit dendritic excitability through the expression of a variety of voltage-gated ion channels. However, despite experimental and theoretical efforts undertaken in the last decades, the role of this excitability for some kind of dendritic computation has remained elusive. Here we show that, owing to very general properties of excitable media, the average output of a model of active dendritic trees is a highly non-linear function of their afferent rate, attaining extremely large dynamic ranges (above 50 dB). Moreover, the model yields double-sigmoid response functions as experimentally observed in retinal ganglion cells. We claim that enhancement of dynamic range is the primary functional role of active dendritic conductances. We predict that neurons with larger dendritic trees should have larger dynamic range and that blocking of active conductances should lead to a decrease of dynamic range.Comment: 20 pages, 6 figure