Final Report for the Period 1 July 1952 to 15 September 1953

Wright Air Force Development Center. United States Air Force.Contract AF 33(616)-170Expenditure Order No. R 449-37 AW-

Critical appraisal and update on the clinical utility of agomelatine, a melatonergic agonist, for the treatment of major depressive disease in adults

This article describes the pharmacology of the novel atypical antidepressant drug agomelatine, critically reviews and evaluates its clinical use for the treatment of major depression, and suggests areas for further research. Agomelatine is a synthetic analog of the hormone melatonin. It stimulates the activity of melatonin MT1 and MT2 receptors and inhibits the activity of serotonin 5HT-2C receptor subtypes. Three acute trials demonstrated clinically modest, but statistically significant benefits over placebo. Three acute trials did not find agomelatine more effective than placebo. A meta-analysis of these six trials demonstrated a small, statistically significant, marginally clinically relevant difference between agomelatine and placebo. The only placebo-controlled study in elderly patients did not demonstrate a significant benefit for agomelatine. It was more effective than placebo in only one of two relapse prevention studies. Agomelatine was generally well tolerated compared to placebo. Its side-effect profile is different than and compares favorably to other antidepressant drugs. The overall tolerability of agomelatine in head-to-head comparisons was not substantially better than active drug comparators. Agomelatine is contraindicated in patients with impaired liver function and in patients taking drugs that potently inhibit CYP-1A2 metabolic enzymes. Because elevated liver enzymes are common, and there is a rare risk of more serious liver reactions, routine laboratory monitoring of liver function is recommended periodically throughout treatment. Agomelatine does not have clinically significant advantages compared to other antidepressant drugs, and it has certain limitations and disadvantages. Because of its unique pharmacology and relatively benign tolerability profile, however, it may be a useful alternative for patients who do not respond to or cannot tolerate other antidepressant drugs. © 2009 Howland, publisher and licensee Dove Medical Press Ltd

Remotely operated high pressure valve protects test personnel

High pressure valve used in testing certain spacecraft systems is safely opened and closed by a remotely stationed operator. The valve is self-regulating in that if the incoming pressure drops below a desired value the valve will automatically close, warning the operator that the testing pressure has dropped to an undesired level

Quantifying high-dimensional entanglement with Einstein-Podolsky-Rosen correlations

Quantifying entanglement in a quantum system generally requires a complete quantum tomography followed by the NP-hard computation of an entanglement monotone --- requirements that rapidly become intractable at higher dimensions. Observing entanglement in large quantum systems has consequently been relegated to witnesses that only verify its existence. In this article, we show that the violation of recent entropic witnesses of the Einstein-Podolsky-Rosen paradox also provides tight lower bounds to multiple entanglement measures, such as the entanglement of formation and the distillable entanglement, among others. Our approach only requires the measurement of correlations between two pairs of complementary observables---not a tomography---so it scales efficiently at high dimension. Despite this, our technique captures almost all the entanglement in common high-dimensional quantum systems, such as spatially or temporally entangled photons from parametric down-conversion.Comment: 7 pages, 2 figures, including Supplemental Materia

Disaster risk management or adaptation to climate change; How to deal with climate issue in Colombia? Analysis from agenda setting and traveling model perspectives of the elaboration of climate policies.

The main purpose of this work is to understand, in an actor oriented perspective, the context in which climate policy are formulated in a country, Colombia. Using agenda setting and travelling model perspectives, we analyzed the role of actors at international and national level on the rise of climate issue and the shape of climate policies. Results showed that the rise of climate issue in Colombia is, from one side, the product of external and internal factors and on the other side, the product of translation chains from several actors on how to see the problem and how to address it. External factors initiated the reflection of CC (international commitments, international actors' translations) but this is an internal factor (Niña phenomenon) that allow a real appropriation of the topic by government members. Government members used traveling model translations as a power issue; the DNP representing at climate change adaptation versus the UNGRD representing at disaster risk management. At the end of the translation chains, government members re-appropriate international consultants' version (of the issue and solution) into an economical perspective; adaptation to climate change as an economical opportunity or as a way to avoid economical loss

Insertion device for pressure testing

Test device which introduces either pressure or vacuum into a test pipe or tube, is insertable into the tested item where it secures itself into position and requires no external support. The unit has an operating range from zero to 25,000 psig and to any vacuum level that available equipment can reach

High pressure air valve Patent

Development and characteristics of high pressure control valv

Efficient high-dimensional entanglement imaging with a compressive sensing, double-pixel camera

We implement a double-pixel, compressive sensing camera to efficiently characterize, at high resolution, the spatially entangled fields produced by spontaneous parametric downconversion. This technique leverages sparsity in spatial correlations between entangled photons to improve acquisition times over raster-scanning by a scaling factor up to n^2/log(n) for n-dimensional images. We image at resolutions up to 1024 dimensions per detector and demonstrate a channel capacity of 8.4 bits per photon. By comparing the classical mutual information in conjugate bases, we violate an entropic Einstein-Podolsky-Rosen separability criterion for all measured resolutions. More broadly, our result indicates compressive sensing can be especially effective for higher-order measurements on correlated systems.Comment: 10 pages, 7 figure

Replaceable filters and cones for flared-tubing connectors

Connector is modified by machining the cone from one end before the fitting is bored to accommodate a metallic-filament type of slip-in filter. Thus, when surface of the cone is damaged, only the cone needs replacement