Measurement of statistical evidence on an absolute scale following thermodynamic principles

Statistical analysis is used throughout biomedical research and elsewhere to assess strength of evidence. We have previously argued that typical outcome statistics (including p-values and maximum likelihood ratios) have poor measure-theoretic properties: they can erroneously indicate decreasing evidence as data supporting an hypothesis accumulate; and they are not amenable to calibration, necessary for meaningful comparison of evidence across different study designs, data types, and levels of analysis. We have also previously proposed that thermodynamic theory, which allowed for the first time derivation of an absolute measurement scale for temperature (T), could be used to derive an absolute scale for evidence (E). Here we present a novel thermodynamically-based framework in which measurement of E on an absolute scale, for which "one degree" always means the same thing, becomes possible for the first time. The new framework invites us to think about statistical analyses in terms of the flow of (evidential) information, placing this work in the context of a growing literature on connections among physics, information theory, and statistics.Comment: Final version of manuscript as published in Theory in Biosciences (2013

Expanded Very Large Arrays Observations of a Proto-Cluster of Molecular Gas-Rich Galaxies at z = 4.05

We present observations of the molecular gas in the GN20 proto-cluster of galaxies at z = 4.05 using the Expanded Very Large Array (EVLA). This group of galaxies is the ideal laboratory for studying the formation of massive galaxies via luminous, gas-rich starbursts within 1.6 Gyr of the big bang. We detect three galaxies in the proto-cluster in CO 2-1 emission, with gas masses (H_2) between 10^(10) and 10^(11) × (α/0.8) M_⊙. The emission from the brightest source, GN20, is resolved with a size ~2'' and has a clear north-south velocity gradient, possibly indicating ordered rotation. The gas mass in GN20 is comparable to the stellar mass (1.3 × 10^(11) × (α/0.8) M_⊙ and 2.3 × 10^(11) M_⊙, respectively), and the sum of gas plus stellar mass is comparable to the dynamical mass of the system (~3.4 × 10^(11)[sin (i)/sin (45°)]^(–2) M_⊙), within a 5 kpc radius. There is also evidence for a tidal tail extending another 2'' north of the galaxy with a narrow velocity dispersion. GN20 may be a massive, gas-rich disk that is gravitationally disturbed, but not completely disrupted. There is one Lyman-break galaxy (BD29079) in the GN20 proto-cluster with an optical spectroscopic redshift within our search volume, and we set a 3σ limit to the molecular gas mass of this galaxy of 1.1 × 10^(10) × (α/0.8) M_⊙

Critical research and advanced technology (CRT) support project

A critical technology base for utility and industrial gas turbines by planning the use of coal-derived fuels was studied. Development tasks were included in the following areas: (1) Combustion - investigate the combustion of coal-derived fuels and methods to minimize the conversion of fuel-bound nitrogen to NOx; (2) materials - understand and minimize hot corrosion; (3) system studies - integrate and focus the technological efforts. A literature survey of coal-derived fuels was completed and a NOx emissions model was developed. Flametube tests of a two-stage (rich-lean) combustor defined optimum equivalence ratios for minimizing NOx emissions. Sector combustor tests demonstrated variable air control to optimize equivalence ratios over a wide load range and steam cooling of the primary zone liner. The catalytic combustion of coal-derived fuels was demonstrated. The combustion of coal-derived gases is very promising. A hot-corrosion life prediction model was formulated and verified with laboratory testing of doped fuels. Fuel additives to control sulfur corrosion were studied. The intermittent application of barium proved effective. Advanced thermal barrier coatings were developed and tested. Coating failure modes were identified and new material formulations and fabrication parameters were specified. System studies in support of the thermal barrier coating development were accomplished

Light and circadian regulation of clock components aids flexible responses to environmental signals

The circadian clock measures time across a 24h period, increasing fitness by phasing biological processes to the most appropriate time of day. The interlocking feedback loop mechanism of the clock is conserved across species; however, the number of loops varies. Mathematical and computational analyses have suggested that loop complexity affects the overall flexibility of the oscillator, including its responses to entrainment signals. We used a discriminating experimental assay, at the transition between different photoperiods, in order to test this proposal in a minimal circadian network (in Ostreococcus tauri) and a more complex network (in Arabidopsis thaliana). Transcriptional and translational reporters in O.tauri primarily tracked dawn or dusk, whereas in A.thaliana, a wider range of responses were observed, consistent with its more flexible clock. Model analysis supported the requirement for this diversity of responses among the components of the more complex network. However, these and earlier data showed that the O.tauri network retains surprising flexibility, despite its simple circuit. We found that models constructed from experimental data can show flexibility either from multiple loops and/or from multiple light inputs. Our results suggest that O.tauri has adopted the latter strategy, possibly as a consequence of genomic reduction

Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline

BACKGROUND: Differential methylation of the two alleles is a hallmark of imprinted genes. Correspondingly, loss of DNA methyltransferase function results in aberrant imprinting and abnormal post-fertilization development. In the mouse, mutations of the oocyte-specific isoform of the DNA methyltransferase Dnmt1 (Dnmt1o) and of the methyltransferase-like Dnmt3L gene result in specific failures of imprint establishment or maintenance, at multiple loci. We have previously shown in humans that an analogous inherited failure to establish imprinting at multiple loci in the female germline underlies a rare phenotype of recurrent hydatidiform mole. RESULTS: We have identified a human homologue of the murine Dnmt1o and assessed its pattern of expression. Human DNMT1o mRNA is detectable in mature oocytes and early fertilized embryos but not in any somatic tissues analysed. The somatic isoform of DNMT1 mRNA, in contrast, is not detectable in human oocytes. In the previously-described family with multi-locus imprinting failure, mutation of DNMT1o and of the other known members of this gene family has been excluded. CONCLUSIONS: Mutation of the known DNMT genes does not underlie familial hydatidiform mole, at least in the family under study. This suggests that trans-acting factors other than the known methyltransferases are required for imprint establishment in humans, a concept that has indirect support from recent biochemical studies of DNMT3L

The kiloparsec-scale star formation law at redshift 4: wide-spread, highly efficient star formation in the dust-obscured starburst galaxy GN20

We present high-resolution observations of the 880 $\mu$m (rest-frame FIR) continuum emission in the z$=$4.05 submillimeter galaxy GN20 from the IRAM Plateau de Bure Interferometer (PdBI). These data resolve the obscured star formation in this unlensed galaxy on scales of 0.3$^{\prime\prime}$$\times$0.2$^{\prime\prime}$ ($\sim$2.1$\times$1.3 kpc). The observations reveal a bright (16$\pm$1 mJy) dusty starburst centered on the cold molecular gas reservoir and showing a bar-like extension along the major axis. The striking anti-correlation with the HST/WFC3 imaging suggests that the copious dust surrounding the starburst heavily obscures the rest-frame UV/optical emission. A comparison with 1.2 mm PdBI continuum data reveals no evidence for variations in the dust properties across the source within the uncertainties, consistent with extended star formation, and the peak star formation rate surface density (119$\pm$8 M$_{\odot}$ yr$^{-1}$ kpc$^{-2}$) implies that the star formation in GN20 remains sub-Eddington on scales down to 3 kpc$^2$. We find that the star formation efficiency is highest in the central regions of GN20, leading to a resolved star formation law with a power law slope of $\Sigma_{\rm SFR}$ $\sim$ $\Sigma_{\rm H_2}^{\rm 2.1\pm1.0}$, and that GN20 lies above the sequence of normal star-forming disks, implying that the dispersion in the star formation law is not due solely to morphology or choice of conversion factor. These data extend previous evidence for a fixed star formation efficiency per free-fall time to include the star-forming medium on $\sim$kpc-scales in a galaxy 12 Gyr ago.Comment: 6 pages, 5 figures, accepted to ApJ

Star complexes and stellar populations in NGC 6822 - Comparison with the Magellanic Clouds

The star complexes (large scale star forming regions) of NGC 6822 were traced and mapped and their size distribution was compared with the size distribution of star complexes in the Magellanic Clouds (MCs). Furthermore, the spatial distributions of different age stellar populations were compared with each other. The star complexes of NGC 6822 were determined by using the isopleths, based on star counts, of the young stars of the galaxy, using a statistical cutoff limit in density. In order to map them and determine their geometrical properties, an ellipse was fitted to every distinct region satisfying this minimum limit. The Kolmogorov-Smirnov statistical test was used to study possible patterns in their size distribution. Isopleths were also used to study the stellar populations of NGC 6822. The star complexes of NGC 6822 were detected and a list of their positions and sizes was produced. Indications of hierarchical star formation, in terms of spatial distribution, time evolution and preferable sizes were found in NGC 6822 and the MCs. The spatial distribution of the various age stellar populations has indicated traces of an interaction in NGC 6822, dated before 350 +/- 50 Myr.Comment: 10 pages, 7 figures, accepted by A&A; minor typeface correction

The compact, ∼1 kpc host galaxy of a quasar at a redshift of 7.1

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations of the [C ii] fine-structure line and the underlying far-infrared (FIR) dust continuum emission in J1120+0641, the most distant quasar currently known ($z=7.1$). We also present observations targeting the CO(2–1), CO(7–6), and [C i] 369 μm lines in the same source obtained at the Very Large Array and Plateau de Bure Interferometer. We find a [C ii] line flux of ${F}_{[{\rm{C}}{\rm{II}}]}=1.11\pm 0.10$ Jy $\mathrm{km}\,{{\rm{s}}}^{-1}$ and a continuum flux density of ${S}_{227\mathrm{GHz}}=0.53\pm 0.04$ mJy beam−1, consistent with previous unresolved measurements. No other source is detected in continuum or [C ii] emission in the field covered by ALMA (~ 25''). At the resolution of our ALMA observations (0farcs23, or 1.2 kpc, a factor of ~70 smaller beam area compared to previous measurements), we find that the majority of the emission is very compact: a high fraction (~80%) of the total line and continuum flux is associated with a region 1–1.5 kpc in diameter. The remaining ~20% of the emission is distributed over a larger area with radius lesssim4 kpc. The [C ii] emission does not exhibit ordered motion on kiloparsec scales: applying the virial theorem yields an upper limit on the dynamical mass of the host galaxy of $(4.3\pm 0.9)\times {10}^{10}$ ${M}_{\odot }$, only ~20 × higher than the central black hole (BH). The other targeted lines (CO(2–1), CO(7–6), and [C i]) are not detected, but the limits of the line ratios with respect to the [C ii] emission imply that the heating in the quasar host is dominated by star formation, and not by the accreting BH. The star formation rate (SFR) implied by the FIR continuum is 105–340 ${M}_{\odot }\,{\mathrm{yr}}^{-1}$, with a resulting SFR surface density of ~100–350 ${M}_{\odot }\,{\mathrm{yr}}^{-1}$ kpc−2, well below the value for Eddington-accretion-limited star formation

The Pulsed Neutron Beam EDM Experiment

We report on the Beam EDM experiment, which aims to employ a pulsed cold neutron beam to search for an electric dipole moment instead of the established use of storable ultracold neutrons. We present a brief overview of the basic measurement concept and the current status of our proof-of-principle Ramsey apparatus