44 research outputs found

    Observation of a new boson at a mass of 125 GeV with the CMS experiment at the LHC

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    P-Type Silicon Strip Sensors for the new CMS Tracker at HL-L-HC

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    Abstract: The upgrade of the LHC to the High-Luminosity LHC (HL-LHC) is expected to increase the LHC design luminosity by an order of magnitude. This will require silicon tracking detectors with a significantly higher radiation hardness. The CMS Tracker Collaboration has conducted an irradiation and measurement campaign to identify suitable silicon sensor materials and strip designs for the future outer tracker at the CMS experiment. Based on these results, the collaboration has chosen to use n-in-p type silicon sensors and focus further investigations on the optimization of that sensor type

    Molecular Modeling and Conformational Analysis of MuSK Protein

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    Part 8: First Workshop on Algorithms for Data and Text Mining in Bioinformatics (WADTMB 2012)International audienceMuscle-specific kinase is a crucial receptor tyrosine kinase required for the development and function of neuromuscular junction. Although many protein domains have already been modeled with crystallographic techniques in various organisms, a single model for the whole human structure is not yet available. A model of the entire protein was constructed by using two parallel Homology Modeling approaches, one unsupervised and one driven by the user. In addition, by applying Molecular Dynamics simulations the present study provides further insights on the structure, and the intermolecular interactions of the protein were examined. The expected semi rigid globular form of the protein was confirmed and in addition a hydrophobic core and a hydrogen bond network that enhances the stability of the molecule were observed. Furthermore, these calculations identified an intriguing rotation of Ig domains and this finding sets the base for additional hypothesis and further investigation

    Biochemistry of hyperthyroidism and hypothyroidism

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