Osteochondritis dissecans and Osgood Schlatter disease in a family with Stickler syndrome

<p>Abstract</p> <p>Purpose</p> <p>Stickler syndrome is among the most common autosomal dominant connective tissue disorders but is often unrecognised and therefore not diagnosed by clinicians. Despite much speculation, the cause of osteochondrosis in general and osteochondritis dissecans (OCD) and Osgood Schlatter syndrome (OSS) in particular remain unclear. Etiological understanding is essential. We describe a pair of family subjects presented with OCD and OSS as a symptom complex rather than a diagnosis.</p> <p>Methods</p> <p>Detailed clinical and radiographic examinations were undertaken with emphasis on the role of MRI imaging. Magnetic resonance imaging may allow early prediction of articular lesion healing potential in patients with Stickler syndrome.</p> <p>Results</p> <p>The phenotype of Stickler syndrome can be diverse and therefore misleading. The expectation that the full clinical criteria of any given genetic disorder such as Stickler syndrome will always be present can easily lead to an underestimation of these serious inheritable disorders. We report here two family subjects, a male proband and his aunt (paternal sister), both presented with the major features of Stickler syndrome. Tall stature with marfanoid habitus, astigmatism/congenital vitreous abnormality and submucus cleft palate/cleft uvula, and enlarged painful joints with early onset osteoarthritis. Osteochondritis dissecans (OCD) and Osgood Schlatter syndrome (OSS) were the predominating joint abnormalities.</p> <p>Conclusion</p> <p>We observed that the nature of the articular and physeal abnormalities was consistent with a localised manifestation of a more generalised epiphyseal dysplasia affecting the weight-bearing joints. In these two patients, OCD and OSS appeared to be the predominant pathologic musculoskeletal consequences of an underlying Stickler's syndrome. It is empirical to consider generalised epiphyseal dysplasia as a major underlying causation that might drastically affect the weight-bearing joints.</p

Spin asymmetries A1 and structure functions g1 of the proton and the deuteron from polarized high energy muon scattering.

Adeva B, Akdogan T, Arik E, et al. Spin asymmetries A(1) and structure functions g(1) of the proton and the deuteron from polarized high energy muon scattering. Phys.Rev. D. 1998;58(11): 112001.We present the final results of the spin asymmetries A(1) and the spin structure functions g(1) of the proton and the deuteron in the kinematic range 0.0008 < x < 0.7 and 0.2 < Q(2) < 100 GeV2. For the determination of A(1), in addition to the usual method which employs inclusive scattering events and includes a large radiative background at low x, we use a new method which minimizes the radiative background by selecting events with at least one hadron as well as a muon in the final state. We find that this hadron method gives smaller errors for x < 0.02, so it is combined with the usual method to provide the optimal set of results. [S0556-2821(98)07017-9]

A NEW MEASUREMENT OF THE SPIN-DEPENDENT STRUCTURE-FUNCTION G(1)(X) OF THE DEUTERON

We present a new measurement of the spin-dependent structure function g(1)(d) of the deuteron in deep inelastic scattering of 190 GeV polarised muons on polarised deuterons, in the kinematic range 0.003<x<0.7 and IGeV2,Q(2)<60GeV(2). This structure function is found to be negative at small x. The first moment Gamma(1)(d)=integral(0)(1)g(1)(d)dx evaluated at Q(0)(2)=10GeV(2) is 0.034+/-0.009(stat.)+/-0.006(syst). This value is below the Ellis-Jaffe sum rule prediction by three standard deviations. Using our earlier determination of Gamma(1)(p), we obtain Gamma(1)(p)-Gamma(1)(n)=0.199+/-0.038 which agrees with the Bjorken sum rule

Polarization of valence and non-strange sea quarks in the nucleon from semi-inclusive spin asymmetries.

Adeva B, Arik E, Arvidson A, et al. Polarisation of valence and non-strange sea quarks in the nucleon from semi-inclusive spin asymmetries. Phys.Lett. B. 1996;369(1):93-100.We present a measurement of semi-inclusive spin asymmetries for positively and negatively charged hadrons from deep inelastic scattering of polarised muons on polarised protons and deuterons in the range 0.003 < x < 0.7. From these asymmetries and the previously published inclusive spin asymmetries we determine, for the first time, the x-dependent spin distributions for up and down valence quarks and for non-strange sea quarks. We find that the first moments of the valence quark spin distributions are Delta u(v) = 1.01 +/- 0.19 +/- 0.14 and Delta d(v) = -0.57 +/- 0.22 +/- 0.11. The spin distribution function of non-strange sea quarks is consistent with zero over the measured range of x and the first moment is Delta (u) over bar = Delta (d) over bar = -0.02 +/- 0.09 +/- 0.03