Tu1781 Description of findings in esophageal impedance-pH monitoring in patients with extraesophageal symtomps and suspected GERD in Hospital San Ignacio Bogota

Q1Q1There are findings that suggest association between extraesophageal symptoms such as cough, laryngitis and chest pain and gastroesophageal reflux disease,. However the cause - effect so far is controversial OBJECTIVE : Describe the findings in esophageal pH monitoring with impedance testing in patients with extraesophageal symptoms and suspected gastroesophageal reflux disease (GERD) in patients referred to Hospital San Ignacio de Bogotá between 2006 and 2010. METHODS AND PATIENTS We review the records of gastrointestinal physiology studies performed un our unit with multichannel intraluminal impedance-ph monitoring between 2006 and 2011, wich indication was extraesophageal symptoms and suspected GERD. Some of our patients was on treatment wiht PPI and others do not. RESULTS We found in our records 348 patients who underwent esophageal impedance - pH monitoring for extraesophageal symptoms and suspected GERD, 234 female (67%) and 114 male (33%). In 198 patients (57%) the test was performed without treatment, and 150 patients (43%) with treatment. The most common manifestation was laryngitis with 49%, followed by coughing up 38%, and chest pain with 13%. In patients where the study was done without treatment, the test was positive for acid reflux in 23% and positive for non acid reflux only in 13% of cases. In patients in whom the procedure was done with treatment, it was positive for acid reflux in 11% and positive for non-acid reflux in 38%. CONCLUSIONS :Esophageal impedance - pH monitoring is useful in determining whether GERD is present in patients with extraesophageal symptoms. It also helps to distinguish between acid reflux and non -acid reflux in this patients . Most of our patients had a negative result for both acid and non acid reflux , which may suggest a poor relation between extraesophageal symptoms and GERD detecting by impedance . ph monitoring wich can be explain because there is a large amount of procedures performed with the wrong indications.https://orcid.org/0000-0002-9219-4548https://orcid.org/0000-0003-1222-0636https://orcid.org/0000-0001-5660-6229https://orcid.org/0000-0002-3841-1484https://orcid.org/0000-0003-2938-7731https://orcid.org/0000-0002-4523-7947Revista Internacional - Indexad

Utilización del polimorfismo del ADN de cloroplastos para definir regiones de procedencia materna en los robles blancos de la Península Ibérica

We present here the results obtained after the study of 156 oak populations collected along the Iberian Peninsula. Six oak species were present in the sample: Quercus canariensis, Q. faginea, Q. humilis, Q. pyrenaica, Q. robur and Q. petraea. Five trees from each population were analyzed with four cpDNA specific pairs of primers that allowed the distinction of 13 haplotypes. In populations with several species, all of them shared the same haplotype, and none of the common haplotypes was restricted to a single species. Analysis of molecular variance in the data revealed a strong genetic structure. Maternal provenance regions were defined that maximize the among groups variance and minimize the among populations/within groups variance. The distribution of the haplotypes suggests the existence of several distinct refugia, not restricted to the South of the Peninsula.En este trabajo se presentan los resultados obtenidos tras el estudio de 156 poblaciones de robles a lo largo de la Península Ibérica. Los robles estudiados pertenecen a seis especies: Quercus canariensis, Q. faginea, Q. humilis, Q. pyrenaica, Q. robur y Q. petraea. Se analizaron cinco árboles de cada población con cuatro pares de cebadores específicos de cpADN, lo que permitió distinguir un total de 13 haplotipos. En las poblaciones en las que había varias especies, generalmente todas mostraron el mismo haplotipo; y ninguno de los haplotipos comunes representa a una sola especie. El análisis de la varianza molecular (AMOVA) ha revelado una fuerte estructura genética. Las regiones de procedencia materna se definieron de tal manera que se maximizara la varianza entre grupos y minimizara la varianza entre poblaciones dentro de grupos. Por último, la distribución de haplotipos sugiere la existencia de diversos refugios glaciares no restringidos únicamente al sur de la Península

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis

MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targets and inhibit bacterial growth by more than one mechanism. Here, we describe a cell-based assay that utilizes two-way regulation of MmpL3 expression to readily identify MmpL3-specific inhibitors. We successfully used this assay to identify a novel guanidine-based MmpL3 inhibitor from a library of 220 compounds that inhibit growth of Mtb by largely unknown mechanisms. We furthermore identified inhibitors of cytochrome bc1-aa3 oxidase as one class of off-target hits in whole-cell screens for MmpL3 inhibitors and report a novel sulfanylacetamide as a potential QcrB inhibitor

Impact of bimetallic interface design on heat generation in plasmonic Au/Pd nanostructures studied by single-particle thermometry

Localized surface plasmons are lossy and generate heat. However, accurate measurement of the temperature of metallic nanoparticles under illumination remains an open challenge, creating difficulties in the interpretation of results across plasmonic applications. Particularly, there is a quest for understanding the role of temperature in plasmon-assisted catalysis. Bimetallic nanoparticles combining plasmonic with catalytic metals are raising increasing interest in artificial photosynthesis and the production of solar fuels. Here, we perform single-particle thermometry measurements to investigate the link between morphology and light-to-heat conversion of colloidal Au/Pd nanoparticles with two different configurations: core–shell and core-satellite. It is observed that the inclusion of Pd as a shell strongly reduces the photothermal response in comparison to the bare cores, while the inclusion of Pd as satellites keeps photothermal properties almost unaffected. These results contribute to a better understanding of energy conversion processes in plasmon-assisted catalysis.Fil: Gargiulo, Julian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Herran, Matias. Ludwig Maximilians Universitat; AlemaniaFil: Violi, Ianina Lucila. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Sousa Castillo, Ana. Ludwig Maximilians Universitat; AlemaniaFil: Martínez, Luciana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Ezendam, Simone. Ludwig Maximilians Universitat; AlemaniaFil: Barella, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Giesler, Helene. Universitat Essen; AlemaniaFil: Grzeschik, Roland. Universitat Essen; AlemaniaFil: Schlücker, Sebastian. Universitat Essen; AlemaniaFil: Maier, Stefan A.. Monash University; Australia. Imperial College London; Reino Unido. Ludwig Maximilians Universitat; AlemaniaFil: Stefani, Fernando Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; ArgentinaFil: Cortés, Emiliano. Ludwig Maximilians Universitat; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentin

On the security of consumer wearable devices in the Internet of Things

Miniaturization of computer hardware and the demand for network capable devices has resulted in the emergence of a new class of technology called wearable computing. Wearable devices have many purposes like lifestyle support, health monitoring, fitness monitoring, entertainment, industrial uses, and gaming. Wearable devices are hurriedly being marketed in an attempt to capture an emerging market. Owing to this, some devices do not adequately address the need for security. To enable virtualization and connectivity wearable devices sense and transmit data, therefore it is essential that the device, its data and the user are protected. In this paper the use of novel Integrated Circuit Metric (ICMetric) technology for the provision of security in wearable devices has been suggested. ICMetric technology uses the features of a device to generate an identification which is then used for the provision of cryptographic services. This paper explores how a device ICMetric can be generated by using the accelerometer and gyroscope sensor. Since wearable devices often operate in a group setting the work also focuses on generating a group identification which is then used to deliver services like authentication, confidentiality, secure admission and symmetric key generation. Experiment and simulation results prove that the scheme offers high levels of security without compromising on resource demands

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

Society urgently needs new, effective medicines for the treatment of tuberculosis. To kick-start the required hit-to-lead campaigns, the libraries of pharmaceutical companies have recently been evaluated for starting points. The GlaxoSmithKline (GSK) library yielded many high-quality hits, and the associated data were placed in the public domain to stimulate engagement by the wider community. One such series, the spiro compounds, are described here. The compounds were explored by a combination of traditional in-house research and open source methods. The series benefits from a particularly simple structure and a short associated synthetic chemistry route. Many members of the series displayed striking potency and low toxicity, and highly promising in vivo activity in a mouse model was confirmed with one of the analogues. Ultimately the series was discontinued due to concerns over safety, but the associated data remain public domain, empowering others to resume the series if the perceived deficiencies can be overcome

Mental health literacy of depression: gender differences and attitudinal antecedents in a representative British sample

Background Poor mental health literacy and negative attitudes toward individuals with mental health disorders may impede optimal help-seeking for symptoms of mental ill-health. The present study examined the ability to recognize cases of depression as a function of respondent and target gender, as well as individual psychological differences in attitudes toward persons with depression. Methods In a representative British general population survey, the ability to correctly recognize vignettes of depression was assessed among 1,218 adults. Respondents also rated the vignettes along a number of attitudinal dimensions and completed measures of attitudes toward seeking psychological help, psychiatric skepticism, and anti-scientific attitudes. Results There were significant differences in the ability to correctly identify cases of depression as a function of respondent and target gender. Respondents were more likely to indicate that a male vignette did not suffer from a mental health disorder compared to a female vignette, and women were more likely than men to indicate that the male vignette suffered from a mental health disorder. Attitudes toward persons with depression were associated with attitudes toward seeking psychological help, psychiatric skepticism, and anti-scientific attitudes. Conclusion Initiatives that consider the impact of gender stereotypes as well as individual differences may enhance mental health literacy, which in turn is associated with improved help-seeking behaviors for symptoms of mental ill-health