redes sociales

LOGRAR UNA BUEN USO DE LAS REDES SOCIALES EN LOS AMBITOS ACADÉMICOS DONDE PERMITA UNA INTERACCIÓN EFECTIVA ENTRE LOS ESTUDIANTES Y LOS PROFESORES.LA IMPORTANCIA DE LAS REDES SOCIALES ENTRE LOS ESTUDIANTES Y PROFESORES DEL NIVEL SUPERIOR, QUE LES PERMITA TENER UNA INTERACCIÓN INTEGRAL Y EFECTIVA QUE SEA CON FINES LÚDICOS Y DE INTERACCIÓN ACADÉMIC

Sistema de información para administrar la practica social del CED Uniminuto Girardot 2012

Habiendo identificado la problemática en la práctica social, se va a elaborar un aplicativo el cual permitirá descargar y subir archivos, lo cual serán de gran ayuda para optimizar los procesos para el seguimiento y el desarrollo de la práctica, ofreciendo eficacia y eficiencia en el desarrollo de las funciones diarias desempeñadas por los grupos de trabajo. En síntesis este es un motivo relevante para el desarrollo de dicho software ya que el control de la práctica se realiza de manera desorganizada lo cual ha originado problemas en las calificaciones por falta de evidencias, registros inexactos e ineficiencia recopilacion de la infomacio

Application of Business Intelligence in the warehouse department as support to improve the planning, logistics and distribution of goods to educational institutions of the State of Mexico

Business intelligence helps to have a better understanding of the Organization, improving the decision-making process, facilitates the way to access and share information, helps to identify 'junk' in information systems and enables analysis in real time. In regards to the Department store, the lack of information of this type, does not have the support necessary to plan and define the logistics and distribution of goods to the Agency (administrative units and schools) in an informed manner, with implications for the maldistribution and misuse of resources, this problematic takes greater importance in the context of the educational reform where one of the important principles is to improve the physical, material and pedagogical conditions in schools

Propuesta para la disminución del síndrome de neurastenia en una empresa financiera en la Ciudad de Toluca

El síndrome de Neurastenia ha sido un padecimiento común caracterizado principalmente por cansancio emocional, despersonalización y falta de realización personal, además de otros padecimientos físicos que llevan a los empleados a mermar su actividad dentro de la organización. Este padecimiento es fácil encontrar en los profesionales que tienen específicamente contacto con los usuarios finales sin embargo no siempre es así; como puede notarse en este estudio el síndrome de Neurastenia se ve inmerso en las tareas diarias de los desarrolladores de software de un sistema financiero ubicado en la ciudad de Toluca, Estado de México

Modelo de gestión de Educación Continua para Instituciones de Educación Superior

El presente trabajo se realiza al vislumbrar la no existencia de un modelo para la gestión de la Educación Continua que permita su adaptación a las diferentes características de las Instituciones de Educación Superior, siendo que los modelos existentes f

Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications

<p>Abstract</p> <p>Background</p> <p>Cervical cancer represents the third most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women worldwide. Natural killer (NK) cells play an important role in the defense against viruses, intracellular bacteria and tumors. NKG2D, an activating receptor on NK cells, recognizes MHC class I chain-related molecules, such as MICA/B and members of the ULBP/RAET1 family. Tumor-derived soluble NKG2D-ligands have been shown to down-modulate the expression of NKG2D on NK cells. In addition to the down-modulation induced by soluble NKG2D-ligands, it has recently been described that persistent cell-cell contact can also down-modulate NKG2D expression. The goal of this study was to determine whether the NKG2D receptor is down-modulated by cell-cell contact with cervical cancer cells and whether this down-modulation might be associated with changes in NK cell activity.</p> <p>Results</p> <p>We demonstrate that NKG2D expressed on NKL cells is down-modulated by direct cell contact with cervical cancer cell lines HeLa, SiHa, and C33A, but not with non-tumorigenic keratinocytes (HaCaT). Moreover, this down-modulation had functional implications. We found expression of NKG2D-ligands in all cervical cancer cell lines, but the patterns of ligand distribution were different in each cell line. Cervical cancer cell lines co-cultured with NKL cells or fresh NK cells induced a marked diminution of NKG2D expression on NKL cells. Additionally, the cytotoxic activity of NKL cells against K562 targets was compromised after co-culture with HeLa and SiHa cells, while co-culture with C33A increased the cytotoxic activity of the NKL cells.</p> <p>Conclusions</p> <p>Our results suggest that differential expression of NKG2D-ligands in cervical cancer cell lines might be associated with the down-modulation of NKG2D, as well as with changes in the cytotoxic activity of NKL cells after cell-cell contact with the tumor cells.</p

MHC class I-related chain A and B ligands are differentially expressed in human cervical cancer cell lines

<p>Abstract</p> <p>Background</p> <p>Natural killer (NK) cells are an important resource of the innate immune system directly involved in the spontaneous recognition and lysis of virus-infected and tumor cells. An exquisite balance of inhibitory and activating receptors tightly controls the NK cell activity. At present, one of the best-characterized activating receptors is NKG2D, which promotes the NK-mediated lysis of target cells by binding to a family of cell surface ligands encoded by the MHC class I chain-related (MIC) genes, among others. The goal of this study was to describe the expression pattern of MICA and MICB at the molecular and cellular levels in human cervical cancer cell lines infected or not with human papillomavirus, as well as in a non-tumorigenic keratinocyte cell line.</p> <p>Results</p> <p>Here we show that MICA and MICB exhibit differential expression patterns among HPV-infected (SiHa and HeLa) and non-infected cell lines (C33-A, a tumor cell line, and HaCaT, an immortalized keratinocyte cell line). Cell surface expression of MICA was higher than cell surface expression of MICB in the HPV-positive cell lines; in contrast, HPV-negative cells expressed lower levels of MICA. Interestingly, the MICA levels observed in C33-A cells were overcome by significantly higher MICB expression. Also, all cell lines released higher amounts of soluble MICB than of soluble MICA into the cell culture supernatant, although this was most pronounced in C33-A cells. Additionally, Real-Time PCR analysis demonstrated that MICA was strongly upregulated after genotoxic stress.</p> <p>Conclusions</p> <p>This study provides evidence that even when MICA and MICB share a high degree of homology at both genomic and protein levels, differential regulation of their expression and cell surface appearance might be occurring in cervical cancer-derived cells.</p

Current guidelines for the implementation of flywheel resistance training technology in sports:a consensus statement

BackgroundFlywheel resistance training has become more integrated within resistance training programs in a variety of sports due to the neuromuscular, strength, and task-specific enhancements reported with this training.ObjectiveThis paper aimed to present the consensus reached by internationally recognized experts during a meeting on current definitions and guidelines for the implementation of flywheel resistance training technology in sports.MethodsNineteen experts from different countries took part in the consensus process; 16 of them were present at the consensus meeting (18 May 2023) while three submitted their recommendations by e-mail. Prior to the meeting, evidence summaries were developed relating to areas of priority. This paper discusses the available evidence and consensus process from which recommendations were made regarding the appropriate use of flywheel resistance training technology in sports. The process to gain consensus had five steps: (1) performing a systematic review of systematic reviews, (2) updating the most recent umbrella review published on this topic, (3) first round discussion among a sample of the research group included in this consensus statement, (4) selection of research group members—process of the consensus meeting and formulation of the recommendations, and (5) the consensus process. The systematic analysis of the literature was performed to select the most up-to-date review papers available on the topic, which resulted in nine articles; their methodological quality was assessed according to AMSTAR 2 (Assessing the Methodological Quality of Systematic Review 2) and GRADE (Grading Recommendations Assessment Development and Evaluation). Statements and recommendations scoring 7–9 were considered appropriate.ResultsThe recommendations were based on the evidence summary and researchers’ expertise; the consensus statement included three statements and seven recommendations for the use of flywheel resistance training technology. These statements and recommendations were anonymously voted on and qualitatively analyzed. The three statements reported a score ranging from 8.1 to 8.8, and therefore, all statements included in this consensus were considered appropriate. The recommendations (1–7) had a score ranging from 7.7 to 8.6, and therefore, all recommendations were considered appropriate.ConclusionsBecause of the consensus achieved among the experts in this project, it is suggested that practitioners and researchers should adopt the guidelines reported in this consensus statement regarding the use of flywheel resistance technology in sports