761 research outputs found
Mixed-magnesium/zinc calix[4]arene complexes: Structure, and ring opening polymerisation studies
Different combinations of organomagnesium reagents and zinc bromide react with either 1,3-dimethoxy-4-tert-butylcalix[4]areneH2 (L(OMe)2H2) or trialkoxycalix[4]arenes (L(OR)3H) (R = n-Pr, n-pentyl) to afford mixed-metal calix[4]arene systems. Intruiging molecular structures are formed and the systems are capable of the ring opening polymerisation of ε-caprolactone under N2, air, or as melts
Differential aging of median and ulnar sensory nerve parameters
Introduction: Nerve conduction velocity slows and amplitude declines with aging. Methods: Median and ulnar sensory nerves were tested at the annual meetings of the American Dental Association. Seven hundred four subjects had at least two observations. The rate of change in the nerve parameters was estimated while controlling for gender, age, change in hand temperature, baseline body mass index (BMI), and change in BMI. Results: Amplitudes of the median sensory nerve action potentials decreased by 0.58 μV per year, whereas conduction velocity decreased at a rate of 0.41 m/s per year. Corresponding values for the ulnar nerve were 0.89 μV and 0.29 m/s per year. The rates of change in amplitudes did not differ, but the median nerve demonstrated a more rapid loss of conduction velocity. Conclusions: The rate of change for the median conduction velocity was higher than previously reported. The rate of change of median conduction velocity was significantly greater than for the ulnar nerve. Muscle Nerve 45: 60–64, 2012Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89485/1/22233_ftp.pd
Scintillation and charge extraction from the tracks of energetic electrons in superfluid helium-4
An energetic electron passing through liquid helium causes ionization along
its track. The ionized electrons quickly recombine with the resulting positive
ions, which leads to the production of prompt scintillation light. By applying
appropriate electric fields, some of the ionized electrons can be separated
from their parent ions. The fraction of the ionized electrons extracted in a
given applied field depends on the separation distance between the electrons
and the ions. We report the determination of the mean electron-ion separation
distance for charge pairs produced along the tracks of beta particles in
superfluid helium at 1.5 K by studying the quenching of the scintillation light
under applied electric fields. Knowledge of this mean separation parameter will
aid in the design of particle detectors that use superfluid helium as a target
material.Comment: 10 pages, 8 figure
Cerebral deficiency of vitamin B5 (D-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's disease
Age Constraints on Brane Models of Dark Energy
Inspired by recent developments in particle physics, the so-called brane
world cosmology seems to provide an alternative explanation for the present
dark energy problem. In this paper, we use the estimated age of high-
objects to constrain the value of the cosmological parameters in some
particular scenarios based on this large scale modification of gravity. We show
that such models are compatible with these observations for values of the
crossover distance between the 4 and 5 dimensions of the order of .Comment: 4 pages, 2 figures, 1 table, to appear in Phys. Rev.
Mirror Energy Differences at Large Isospin Studied through Direct Two-Nucleon Knockout
The first spectroscopy of excited states in Ni52 (Tz=-2) and Co51 (Tz=-3/2) has been obtained using the highly selective two-neutron knockout reaction. Mirror energy differences between isobaric analogue states in these nuclei and their mirror partners are interpreted in terms of isospin nonconserving effects. A comparison between large-scale shell-model calculations and data provides the most compelling evidence to date that both electromagnetic and an additional isospin nonconserving interactions for J=2 couplings, of unknown origin, are required to obtain good agreement. � 2013 American Physical Society
Development of Finger Clubbing Meter
Finger clubbing, also known as drumstick finger, is the medical symptom that is indicated
by the development of the sponginess or swelling in the nail beds of nails and toes. The higher grade
of clubbing on the patients can be easily identified with the presence of drumstick finger. The
existing available measurement device to identify the early stage of clubbing required much time
which is impractical for a busy clinic practice. This paper explains the determination of the finger
clubbing by using the Digital Index (DI) measurement, which was deployed by implementing and
developing the Portable Finger Clubbing Meter hardware and the Microsoft Visual Basic (VB)
Graphical User Interface (GUI). Finger circumference values of nail-fold (NF) and distal
interphalangeal joint (DIP) of twenty participants were measured using the developed hardware.
Data analysis was then performed using the GUI for DI computation, and the presence of finger
clubbing could be determined
An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma
The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing and implicated in more than 60% of all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, and proteome analyses have identified altered signaling pathways in HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology of OPSCC. Herein, bioinformatics analyses of human HPV(+) HNSCCs revealed that all tumors express full-length E6 and identified molecular subtypes based on relative E6 and E7 expression levels. To recapitulate the levels, stoichiometric ratios, and anatomic location of E6/E7 expression, we generated a genetically engineered mouse model whereby balanced expression of E6/E7 is directed to the oropharyngeal epithelium. The addition of a mutant PIK3CAE545K allele leads to the rapid development of pre-malignant lesions marked by immune cell accumulation, and a subset of these lesions progress to OPSCC. This mouse provides a faithful immunocompetent model for testing treatments and investigating mechanisms of immunosuppression
Brane World Cosmologies and Statistical Properties of Gravitational Lenses
Brane world cosmologies seem to provide an alternative explanation for the
present accelerated stage of the Universe with no need to invoke either a
cosmological constant or an exotic \emph{quintessence} component. In this paper
we investigate statistical properties of gravitational lenses for some
particular scenarios based on this large scale modification of gravity. We show
that a large class of such models are compatible with the current lensing data
for values of the matter density parameter
(). If one fixes to be , as suggested by
most of the dynamical estimates of the quantity of matter in the Universe, the
predicted number of lensed quasars requires a slightly open universe with a
crossover distance between the 4 and 5-dimensional gravities of the order of
.Comment: 6 pages, 3 figures, revte
Strategies to build a positive and inclusive Antarctic field work environment
Support from National Science Foundation (NSF: Grants 1738913, 1738896, 1738942, 1738992, 1738896, 1738934) and Natural Environment Research Council (NERC: Grants NE/S006788/1, NE/S006605/1, NE/S00677X/1). This research was supported in part by the NOAA cooperative agreement NA17OAR4320101. Logistics provided by NSF-U.S. Antarctic Program and NERC-British Antarctic Survey. ITGC Contribution No. ITGC-084.To increase inclusivity, diversity, equity and accessibility in Antarctic science, we must build more positive and inclusive Antarctic field work environments. The International Thwaites Glacier Collaboration (ITGC) has engaged in efforts to contribute to that goal through a variety of activities since 2018, including creating an open-access 'Field and Ship Best Practices' guide, engaging in pre-field season team dynamics meetings, and surveying post-field season reflections and experiences. We report specific actions taken by ITGC and their outcomes. We found that strong and supported early career researchers brought new and important perspectives regarding strategies for transforming culture. We discovered that engaged and involved senior leadership was also critical for expanding participation and securing funding to support efforts. Pre-field discussions involving all field team members were particularly helpful for setting expectations, improving sense of belonging, describing field work best practices, and co-creating a positive work culture.Publisher PDFPeer reviewe
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