The underlying conditionality of conditionals which do not use 'if'

In addressing a question at the semantics-pragmatics interface of how conditionals in English should be categorised, this paper addresses the underlying question: what is a conditional? Conditionals in English are very often associated with the canonical pattern ‘if p then q’. But while the word 'if' provides a simple function to aid us in expressing our conditional thought, it goes without saying that conditional thought does not go hand in hand with the single word 'if'. This paper explores some of the ways that conditionals may be expressed in English without using if by presenting observations obtained from the International Corpus of English (ICE-GB) combined with results from previous empirical studies (e.g. Declerck & Reed 2001). In doing so, this paper considers the question what exactly it is to be a conditional, proposing some criteria to guide the categorisation of conditional expressions. In turn, this paper aims to shed some light as to why conditionals using 'if' are so often focussed upon

Classifying conditionals: The case of metalinguistic 'if you like'

It is agreed that metalinguistic ‘if you like’ puts some aspect of communication into metalinguistic focus, serving the pragmatic function of commenting upon the appropriateness of the words uttered, but there is little consensus as to whether metalinguistic ‘if you like’ introduces a conditional. By taking observations from the International Corpus of English, this paper aims to show that utterances using metalinguistic ‘if you like’ belong in the class of conditional expressions. This is achieved by proposing pragmatic criteria to guide the categorisation of conditional expressions, where conditionality is not inherently linked to truth-conditional content. Next, this paper argues that ‘if you like’ can be classed in the broad category of speechact conditionals, where it is not the truth of the if-clause that provides the situations of truth of the main clause, but rather where the if-clause refers to the situations where the main clause is felicitously used. Finally, by utilising the semantic contextualist framework of Default Semantics (Jaszczolt 2010), this paper shows that ‘if you like’ is comparable to other if-clauses which overtly invoke a metalinguistic sense in a full phrase. In sum, this paper takes the case of ‘if you like’ as a case study in re-conceptualising the class of conditionals and truth-conditional content

The interactional achievement of speaker meaning: Toward a formal account of conversational inference

Dominant accounts of ‘speaker meaning’ in post-Gricean contextualist pragmatics tend to focus on single utterances, making the theoretical assumption that the object of pragmatic analysis is restricted to cases where speakers and hearers agree on utterance meanings, leaving instances of misunderstandings out of their scope. However, we know that divergences in understandings between interlocutors do often arise, and that when they do, speakers can engage in a local process of meaning negotiation. In this paper, we take insights from interactional pragmatics to offer an empirically informed view on ‘speaker meaning’ that incorporates both speakers’ and hearers’ perspectives, alongside a formalisation of how to model speaker meanings in such a way that we can account for both understandings – the canonical cases – and misunderstandings, but critically, also the process of interactionally negotiating meanings between interlocutors. We thus highlight that utterance-level theories of meaning provide only a partial representation of speaker meaning as it is understood in interaction, and show that inferences about a given utterance at any given time are formally connected to prior and future inferences of all participants. Our proposed model thus provides a more fine-grained account of how speakers converge on ‘speaker meanings’ in real time, showing how such meanings are often subject to a joint endeavour of complex inferential work

Surface reconstruction of wear in carpets by using a wavelet edge detector

Carpet manufacturers have wear labels assigned to their products by human experts who evaluate carpet samples subjected to accelerated wear in a test device. There is considerable industrial and academic interest in going from human to automated evaluation, which should be less cumbersome and more objective. In this paper, we present image analysis research on videos of carpet surfaces scanned with a 3D laser. The purpose is obtaining good depth Images for an automated system that should have a high percentage of correct assessments for a wide variety of carpets. The innovation is the use of a wavelet edge detector to obtain a more continuously defined surface shape. The evaluation is based on how well the algorithms allow a good linear ranking and a good discriminance of consecutive wear labels. The results show an improved linear ranking for most carpet types, for two carpet types the results are quite significant

Linking the Value Assessment of Oil and Gas Firms to Ambidexterity Theory Using a Mixture of Normal Distributions

Oil and gas exploration and production firms have return profiles that are not easily explained by current financial theory – the variation in their market returns is non-Gaussian. In this paper, the nature and underlying reason for these significant deviations from expected behavior are considered. Understanding these differences in financial market behavior is important for a wide range of reasons, including: assessing investments, investor relations, decisions to raise capital, assessment of firm and management performance. We show that using a “thicker tailed” mixture of two normal distributions offers a significantly more accurate model than the traditionally Gaussian approach in describing the behavior of the value of oil and gas firms. This mixture of normal distribution is also more effective in bridging the gap between management theory and practice without the need to introduce complex time-sensitive GARCH and/or jump diffusion dynamics. The mixture distribution is consistent with ambidexterity theory that suggests firms operate in two distinct states driven by the primary focus of the firm: an exploration state with high uncertainty and, an exploitation (or production) state with lower uncertainty. The findings have direct implications on improving the accuracy of real option pricing techniques and futures analysis of risk management. Traditional options pricing models assume that commercial returns from these assets are described by a normal random walk. However, a normal random walk model discounts the possibility of large changes to the marketplace from events such as the discovery of important reserves or the introduction of new technology. The mixture distribution proves to be well suited to inherently describe the unusually large risks and opportunities associated with oil and gas production and exploration. A significance testing study of 554 oil and gas exploration and production firms empirically supports using a mixture distribution grounded in ambidexterity theory to describe the value fluctuations for these firms

Long-term remission of myopic choroidal neovascular membrane after treatment with ranibizumab: a case report

<p>Abstract</p> <p>Introduction</p> <p>Myopia has become a big public health problem in certain parts of the world. Sight-threatening complications like choroidal neovascularisation membranes occur in up to 10% of pathological myopia, and natural history studies show a trend towards progressive visual loss. There are long-term financial and quality-of-life implications in this group of patients, and treatment strategies should aim for long-term preservation of vision.</p> <p>Case presentation</p> <p>A 56-year-old Caucasian woman presented with a best-corrected visual acuity of 6/6-1 in her right eye and 6/24 in her left. Fundal examination revealed pathological myopia in both eyes and an elevated lesion associated with pre-retinal haemorrhage in the left macula. Ocular coherence tomography and fundus fluorescein angiogram confirmed a subfoveal classic choroidal neovascularisation membrane. The patient decided to proceed with intravitreal ranibizumab (0.5 mg) therapy. One month after treatment, best-corrected visual acuity improved to 6/12 in her left eye, with complete resolution subretinal fluid on ocular coherence tomography. After three months, best-corrected visual acuity further improved to 6/9, which was maintained up to 16 months post-treatment.</p> <p>Conclusion</p> <p>We suggest intravitreal ranibizumab as an alternative treatment for long-term remission of myopic choroidal neovascular membrane. It also suggests that myopic choroidal neovascularisation membranes may require fewer treatments to achieve sustained remission. Furthermore, this could serve as a feasible long-term management option if used in conjunction with ocular coherence tomography.</p

Anti-Cancer Effect of HIV-1 Viral Protein R on Doxorubicin Resistant Neuroblastoma

Several unique biological features of HIV-1 Vpr make it a potentially powerful agent for anti-cancer therapy. First, Vpr inhibits cell proliferation by induction of cell cycle G2 arrest. Second, it induces apoptosis through multiple mechanisms, which could be significant as it may be able to overcome apoptotic resistance exhibited by many cancerous cells, and, finally, Vpr selectively kills fast growing cells in a p53-independent manner. To demonstrate the potential utility of Vpr as an anti-cancer agent, we carried out proof-of-concept studies in vitro and in vivo. Results of our preliminary studies demonstrated that Vpr induces cell cycle G2 arrest and apoptosis in a variety of cancer types. Moreover, the same Vpr effects could also be detected in some cancer cells that are resistant to anti-cancer drugs such as doxorubicin (DOX). To further illustrate the potential value of Vpr in tumor growth inhibition, we adopted a DOX-resistant neuroblastoma model by injecting SK-N-SH cells into C57BL/6N and C57BL/6J-scid/scid mice. We hypothesized that Vpr is able to block cell proliferation and induce apoptosis regardless of the drug resistance status of the tumors. Indeed, production of Vpr via adenoviral delivery to neuroblastoma cells caused G2 arrest and apoptosis in both drug naïve and DOX-resistant cells. In addition, pre-infection or intratumoral injection of vpr-expressing adenoviral particles into neuroblastoma tumors in SCID mice markedly inhibited tumor growth. Therefore, Vpr could possibly be used as a supplemental viral therapeutic agent for selective inhibition of tumor growth in anti-cancer therapy especially when other therapies stop working

Preparation and Characterization of P(2)BCh Ring Systems (Ch=S, Se) and Their Reactivity with N-Heterocyclic Carbenes

Four-membered rings with a P2BCh core (Ch = S, Se) have been synthesized via reaction of phosphinidene chalcogenide (Ar*P=Ch) and phosphaborene (Mes*P=BNR2). The mechanistic pathways towards these rings are explained by detailed computational work that confirmed the preference for the formation of P–P, not P–B, bonded systems, which seems counterintuitive given that both phosphorus atoms contain bulky ligands. The reactivity of the newly synthesized heterocycles, as well as that of the known (RPCh)n rings (n = 2, 3), was probed by the addition of Nheterocyclic carbenes, which revealed that all investigated compounds can act as sources of low-coordinate phosphorus species.peerReviewe