Association between actual weight status, perceived weight and depressive, anxious symptoms in Chinese adolescents: a cross-sectional study

<p>Abstract</p> <p>Backgroud</p> <p>The purpose of this study was to describe actual measured weight and perceived weight and to explore associations with depressive, anxiety symptoms in school adolescents in China.</p> <p>Methods</p> <p>A sample of 1144 Chinese adolescents was randomly selected from four schools in Wuhan, China, including 665 boys and 479 girls with ages ranging between 10 and 17 years. Actual measured weight and height and perceived weight status were compared to anxiety and depressive symptoms measured using the revised Self-Rating Anxiety Scale and Children's Depression Inventory. A general linear model was used to compare differences in psychological symptoms among the teenagers with different measured and perceived weights.</p> <p>Results</p> <p>When compared with standardized weight tables (WHO age- and gender-specific body mass index (BMI) cutoffs (2007 reference)), girls were more likely to misperceive themselves as overweight, whereas more boys misclassified their weight status as underweight. The adolescents who perceived themselves as overweight were more likely to experience depressive and anxiety symptoms (except girls) than those who perceived themselves as normal and/or underweight. However, no significant association was found between depressive and anxiety symptoms actual measured weight status.</p> <p>Conclusions</p> <p>Perceived weight status, but not the actual weight status, was associated with psychological symptoms.</p

Laparoscopic versus conventional appendectomy - a meta-analysis of randomized controlled trials

<p>Abstract</p> <p>Background</p> <p>Although laparoscopic surgery has been available for a long time and laparoscopic cholecystectomy has been performed universally, it is still not clear whether open appendectomy (OA) or laparoscopic appendectomy (LA) is the most appropriate surgical approach to acute appendicitis. The purpose of this work is to compare the therapeutic effects and safety of laparoscopic and conventional "open" appendectomy by means of a meta-analysis.</p> <p>Methods</p> <p>A meta-analysis was performed of all randomized controlled trials published in English that compared LA and OA in adults and children between 1990 and 2009. Calculations were made of the effect sizes of: operating time, postoperative length of hospital stay, postoperative pain, return to normal activity, resumption of diet, complications rates, and conversion to open surgery. The effect sizes were then pooled by a fixed or random-effects model.</p> <p>Results</p> <p>Forty-four randomized controlled trials with 5292 patients were included in the meta-analysis. Operating time was 12.35 min longer for LA (95% CI: 7.99 to 16.72, p < 0.00001). Hospital stay after LA was 0.60 days shorter (95% CI: -0.85 to -0.36, p < 0.00001). Patients returned to their normal activity 4.52 days earlier after LA (95% CI: -5.95 to -3.10, p < 0.00001), and resumed their diet 0.34 days earlier(95% CI: -0.46 to -0.21, p < 0.00001). Pain after LA on the first postoperative day was significantly less (p = 0.008). The overall conversion rate from LA to OA was 9.51%. With regard to the rate of complications, wound infection after LA was definitely reduced (OR = 0.45, 95% CI: 0.34 to 0.59, p < 0.00001), while postoperative ileus was not significantly reduced(OR = 0.91, 95% CI: 0.57 to 1.47, p = 0.71). However, intra-abdominal abscess (IAA), intraoperative bleeding and urinary tract infection (UIT) after LA, occurred slightly more frequently(OR = 1.56, 95% CI: 1.01 to 2.43, p = 0.05; OR = 1.56, 95% CI: 0.54 to 4.48, p = 0.41; OR = 1.76, 95% CI: 0.58 to 5.29, p = 0.32).</p> <p>Conclusion</p> <p>LA provides considerable benefits over OA, including a shorter length of hospital stay, less postoperative pain, earlier postoperative recovery, and a lower complication rate. Furthermore, over the study period it was obvious that there had been a trend toward fewer differences in operating time for the two procedures. Although LA was associated with a slight increase in the incidence of IAA, intraoperative bleeding and UIT, it is a safe procedure. It may be that the widespread use of LA is due to its better therapeutic effect.</p

Evaluation of ER, PgR, HER-2 and Ki-67 as predictors of response to neoadjuvant anthracycline chemotherapy for operable breast cancer

Primary systemic therapy (PST) for operable breast cancer enables the identification of in vivo biological markers that predict response to treatment. A total of 118 patients with T2–4 N0–1 M0 primary breast cancer received six cycles of anthracycline-based PST. Clinical and radiological response was assessed before and after treatment using UICC criteria. A grading system to score pathological response was devised. Diagnostic biopsies and postchemotherapy surgical specimens were stained for oestrogen (ER) and progesterone (PgR) receptor, HER-2 and cell proliferation (Ki-67). Clinical, radiological and pathological response rates were 78, 72 and 38%, respectively. There was a strong correlation between ER and PgR staining (P<0.0001). Higher Ki-67 proliferation indices were associated with PgR− tumours (median 28.3%, PgR+ 22.9%; P=0.042). There was no relationship between HER-2 and other biological markers. No single pretreatment or postchemotherapy biological parameter predicted response by any modality of assessment. In all, 10 tumours changed hormone receptor classification after chemotherapy (three ER, seven PgR); HER-2 staining changed in nine cases. Median Ki-67 index was 24.9% before and 18.1% after treatment (P=0.02); the median reduction in Ki-67 index after treatment was 21.2%. Tumours displaying >75% reduction in Ki-67 after chemotherapy were more likely to achieve a pathological response (77.8 vs 26.7%, P=0.004)

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis

Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods: ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion: This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS

Damage potential of earthquake records for RC building stock

This study investigates ground motion parameters and their damage potential for building type structures. It focuses on low and mid-rise reinforced concrete buildings that are important portion of the existing building stock under seismic risk in many countries. Correlations of 19 parameters of 466 earthquake records with nonlinear displacement demands of 1056 Single Degree of Freedom (SDOF) systems are investigated. Properties of SDOF systems are established to represent RC building construction practice. The correlation of damage and ground motion characteristics is examined with respect to number of story and site classes. Equations for average nonlinear displacement demands of considered RC buildings are given for some of the ground motion parameters. Velocity related parameters are generally found to have better results than the acceleration, displacement and frequency related ones. Correlation of the parameters may be expected to decrease with increasing intensity of seismic event. Velocity Spectrum Intensity and Peak Ground Velocity have been found to have the highest correlation values for almost all site classes and number of story groups. Common parameter of Peak Ground Acceleration has lower correlation with damage when compared to them and some other parameters like Effective Design Acceleration and Characteristic Intensity

Evaluation of reasons of the damages after Simav and Van (2011) earthquakes

Turkey is located on a region with high seismicity. The intense seismic activity in 2011, especially Simav and Van earthquakes, once again reminded of this fact. The aim of this study is to give information on the causes of the heavy damage and loss of lives after these earthquakes which are not incompliance with engineering principles. Based on the investigations, the damaged buildings are found to have similar deficiencies as inadequate detailing, material properties, faults in application and design. The most important reasons of the collapses are insufficient strength of joint regions and lap splice lengths. The following flaws are: inadequacies in amount or/and detailing of the lateral reinforcements, short column, overhang and soft story effects, deficient isolation applications and gable wall construction, low concrete strength, pounding and collision between buildings and faulty load bearing system designs. The other remarkable observations after the earthquakes are: the dependency of the seismic damages to some other parameters beside distance to the epicenter, adequate performances of the retrofitted buildings, total collapse of even shear-wall buildings with heavy flaws, buildings with high concrete strength may be heavily damaged, buildings with flexible load carrying system may take significant architectural damage without structural, for moderate and heavy damages 4-5 story buildings are the most damaged ones, even the multi story adobe buildings that are built in accordance with technical provisions may survive the earthquake without damage, therefore the main reason for the devastation is the violation of the engineering principles

Seismic evaluation of existing mid-rise reinforced concrete buildings according to specification for building structures to be built in disaster areas

Over the past several decades, Turkey has been hit by devastating earthquakes and remarkable number of reinforced concrete buildings has been damaged in the high seismicity regions of our country. The aim of this study is to evaluate the seismic performance of the mid-rise reinforced concrete buildings that are major part of building stock of our earthquake-prone country, according to recent Turkish Earthquake Code. 4- and 7-story buildings were selected to represent mid-rise building stock. After determining the structural parameters, each building was subjected to pushover analysis and the capacity curves were obtained. Earthquake performance of each building was determined in the light of their capacity curves according to the recent Turkish Earthquake Code

Evaluation of the main parameters affecting seismic performance of the

Low and mid-rise reinforced concrete (RC) buildings consist of an important portion of the building stock in many earthquake prone countries. Therefore understanding their seismic behaviour is important for mitigation studies. This study aims to evaluate how much and when; seismic code, number of stories, concrete strength, amount of transverse reinforcement and infill-wall contribution parameters are important for seismic performances of RC buildings. Seismic performances of the models reflecting different cases are determined for different performance levels and seismic loading conditions. Based on the considered values of the parameters, it is concluded that: modern code specifications and higher transverse reinforcement 50%, the concrete strength up to 66%, infill-walls 15% and number of story 55% increase the seismic performance for life safety level. Evaluations on the effect of the considered parameters for different performance levels and seismic loadings in relation with other parameters are also given in this paper

Earthquakes

Two destructive earthquakes occurred on October 23 and November 9, 2011 in Van province of Turkey. The damage in residential units shows significant deviation from the expectation of decreasing damage with increasing distance to epicenter The most damaged settlement Ercis has the same distance to the epicenter with Muradiye, where no damage occurred while relatively less damage observed in Van having half distance. These three cities seem to have resembling soil conditions. If the damages are evaluated: joint failures and insufficient lap splice lengths are observed to be the main causes of the total collapses in RC buildings. Additionally, low concrete strength, reinforcement detailing mistakes, soft story, heavy overhang, pounding and short columns are among other damage reasons. Examples of damages due to non-structural elements are also given. Remarkable points about seismic damages are: collapsed buildings with shear-walls, heavily damaged buildings despite adequate concrete strength due to detailing mistakes, undamaged two-story adobe buildings close to totally collapsed RC ones and undamaged structural system in buildings with heavily damaged non-structural elements. On the contrary of the common belief that buildings with shear-walls are immune to total collapse among civil engineers, collapse of Gedikbulak primary school is a noteworthy example