A Minimum-Labeling Approach for Reconstructing Protein Networks across Multiple Conditions

The sheer amounts of biological data that are generated in recent years have driven the development of network analysis tools to facilitate the interpretation and representation of these data. A fundamental challenge in this domain is the reconstruction of a protein-protein subnetwork that underlies a process of interest from a genome-wide screen of associated genes. Despite intense work in this area, current algorithmic approaches are largely limited to analyzing a single screen and are, thus, unable to account for information on condition-specific genes, or reveal the dynamics (over time or condition) of the process in question. Here we propose a novel formulation for network reconstruction from multiple-condition data and devise an efficient integer program solution for it. We apply our algorithm to analyze the response to influenza infection in humans over time as well as to analyze a pair of ER export related screens in humans. By comparing to an extant, single-condition tool we demonstrate the power of our new approach in integrating data from multiple conditions in a compact and coherent manner, capturing the dynamics of the underlying processes.Comment: Peer-reviewed and presented as part of the 13th Workshop on Algorithms in Bioinformatics (WABI2013

Tcnq-based Porous Coordination Polymers Synthesis and Sorption Properties Study in Magnetic Field

Porous coordination polymers (PCPs) were synthesized with used TCNQ anion that acts as cross linker connecting and bipyridine to form a 3D framework. In these study, we use zinc and manganese metal ion as centre of complex coordination. Green crystal of Zn(TCNQ-TCNQ)bpy.1.5 benzene and Mn(TCNQ-TCNQ)bpy.1.5 benzene was successfully synthesized in no under magnetic field (0T) and under magnetic field 6T. XRD patterns of Zn(TCNQ-TCNQ)bpy.1.5 benzene 0T and 6T shown not significant different pattern that indicate no different crytal formed. XRD patterns of Mn(TCNQ-TCNQ)bpy.1.5 benzene also shown not significant different but we found five different intensity ratio peaks that possibility it was a little bit changing of crystal structure. To investigate the pores properties, adsorption isotherm was performe for oxygen gas in 77 K and the guest of benzene were removed at 413 K for 3 hours under low pressure. Zn(TCNQ-TCNQ)bpy}1.5benzene 0T and 6T oxygen adsorption isotherms shows the unique sorption isotherms by gate pressure profile. On other hand, Mn(TCNQ-TCNQ)bpy}1.5 benzene 0T and 6T shows type 1 adsorption isotherms for micropores materials. Adsorption isotherm was also determined in magnetic field 6T for all crystal, and shows shift of gate pressure for Zn compounds and enhance the amount of oxygen adsorbed for all kind of compounds

Magnetic and electric properties in the distorted tetrahedral spin chain system Cu3Mo2O9

We study the multiferroic properties in the distorted tetrahedral quasi-one dimensional spin system Cu$_3$Mo$_2$O$_9$, in which the effects of the low dimensionality and the magnetic frustration are expected to appear simultaneously. We clarify that the antiferromagnetic order is formed together with ferroelectric properties at $T_{\rm N}=7.9$ K under zero magnetic field and obtain the magnetic-field-temperature phase diagram by measuring dielectric constant and spontaneous electric polarization. It is found that the antiferromagnetic phase possesses a spontaneous electric polarization parallel to the c axis when the magnetic field $H$ is applied parallel to the a axis. On the other hand, there are three different ferroelectric phases in the antiferromagnetic phase for $H$ parallel to the c axis.Comment: 4 pages, 3 figures, LT26 proceedings, accepted for publication in J. Phys.: Conf. Se

Cerâmica: interação e produção de sentido na educação a distância.

Esta pesquisa objetiva observar as interações entre os alunos, professores e tutores presentes no Ambiente Virtual de Aprendizagem, objetivando uma compreensão do contexto analisado e das atitudes e interações no processo de ensino e aprendizagem que ocorre nesse ambiente virtual. Para a análise, foram selecionados os fóruns (Fórum Construir Saberes, Fórum Tira Dúvidas e Fórum de Tutores) da disciplina Cerâmica, do Curso de Artes Visuais Licenciatura, modalidade semipresencial, da Universidade Federal do Espírito Santo (Ufes). Como o curso foi ofertado para 22 polos de formação, elegeram-se para análise as postagens dos alunos de Aracruz e Santa Teresa. A metodologia utilizada foi a etnografia virtual, por abranger estudos no/do ciberespaço e no/do ambiente virtual. Como referencial analítico, foram utilizados os pressupostos da sociossemiótica, especialmente com base no pesquisador Eric Landowski (1992, 2001, 2002, 2005) por possibilitar a apreensão dos sentidos presentes nos discursos e nas práticas educativas do/no ambiente virtual. No ambiente virtual, a construção do conhecimento ocorre, num primeiro momento, sem a necessidade da relação presencial entre o professor e o aluno, e as narrativas tornam-se instrumentos de mediação na construção desse conhecimento. Nesse ambiente, as relações são estabelecidas a partir da constituição de diferentes tipos de papéis e identidades. É por meio dessa interação, mediada pelo Ambiente Virtual de Aprendizagem (AVA), que os sujeitos envolvidos constroem suas ações e seus atos a partir de cada deslocamento e participação nesse ambiente virtual, remodelando e redefinindo suas práticas. Landowski (2009) afirma que nossas relações são carregadas de sentido, de emoções que brotam da nossa experiência cotidiana, invalidando qualquer forma de objetividade e regularidade previsível, pois se trata do sentido. É esse sentido que esta pesquisa pretende revelar, por meio dos regimes da semiótica discursiva

ARSENIC REMOVAL FROM GROUNDWATER USING INDIGENOUS IRON AND MANGANESE OXDIZING BACTERIA

Joint Research on Environmental Science and Technology for the Eart

Electroretinographically-determined scotopic spectral sensitivities of some marine fish

The b-wave threshold spectral sensitivity was determined in three species of marine fish. In all cases, the action spectrum of the dark adapted animal peaked at 510-520 nm and fit Dartnall's template curve for the extinction spectrum of a vitamin A1-based visual pigment. High frequency flicker of the stimulus on a white background revealed a long-wavelengthsensitive photopic mechanism, establishing that these were duplex retinas. We conclude that in these teleosts, the dark adapted b-wave is a reliable indicator of rod function, in marked distinction to the case with goldfish and carp.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33877/1/0000138.pd

Electric polarization induced by Neel order without magnetic superlattice: experimental study of Cu3Mo2O9 and numerical study of a small spin cluster

We clarify that the antiferromagnetic order in the distorted tetrahedral quasi-one dimensional spin system induces electric polarizations. In this system, the effects of the low dimensionality and the magnetic frustration are expected to appear simultaneously. We obtain the magnetic-field-temperature phase diagram in Cu3Mo2O9 by studying the dielectric constant and the spontaneous electric polarization. Around the tricritical point at 10 T and 8 K, the change of the direction in the electric polarization causes a colossal magnetocapacitance. We calculate the charge redistribution in the small spin cluster consisting of two magnetic tetrahedra to demonstrate the electric polarization induced by the antiferromagnetism.Comment: 10 pages 6 figures, in press in J. Phys. Soc. Jp