Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes

TCL1 and TCL1b genes on human chromosome 14q23.1 are activated in T cell leukemias by translocations and inversions at 14q32.1, juxtaposing them to regulatory elements of T cell receptor genes. In this report we present the cloning, mapping, and expression analysis of the human and murine TCL1/Tcl1 locus. In addition to TCL1 and TCL1b, the human locus contains two additional genes, TCL1-neighboring genes (TNG) 1 and 2, encoding proteins of 141 and 110 aa, respectively. Both genes show no homology to any known genes, but their expression profiles are very similar to those of TCL1 and TCL1b. TNG1 and TNG2 also are activated in T cell leukemias with rearrangements at 14q32.1. To aid in the development of a mouse model we also have characterized the murine Tcl1 locus and found five genes homologous to human TCL1b. Tcl1b1- Tcl1b5 proteins range from 117 to 123 aa and are 65-80% similar, but they show only a 30-40% similarity to human TCL1b. All five mouse Tcl1b and murine Tcl1 mRNAs are abundant in mouse oocytes and two-cell embryos but rare in various adult tissues and lymphoid cell lines. These data suggest a similar or complementary function of these proteins in early embryogenesis

Undergraduate Neuroscience Education in the U.S.: An Analysis using Data from the National Center for Education Statistics

Despite an apparent increase in undergraduate neuroscience programs offered by colleges and universities, there has been little effort to document this growth. In the present report we describe our analysis of the expansion of undergraduate neuroscience programs of study over more than 20 years and detail a number of institutional characteristics of colleges and universities that offer undergraduate neuroscience programs. These data reveal more than 100 institutions with undergraduate neuroscience programs as well as over 2000 college graduates that majored in neuroscience in 2008–2009. Understanding the current number as well as growth trends of undergraduate neuroscience programs found in U.S. colleges and universities has implications for neuroscience educators as well as for the funding of neuroscience research and educational activities

Nordic dietary surveys. Study designs, methods, results and use in food-based risk assessments

National dietary surveys have been completed in all five Nordic countries for purposes of nutritional assessment. The NORDIRA project started in 2009 with objectives of sharing experiences within collection of food consumption data and applications of it in food-based risk assessment. The NORDIRA-group consisted of experts working within dietary surveys as well within risk assessment. The project collected results and methodological aspects of national dietary surveys, the presentations of food consumption figures and data calculation processes of risk assessment. This TemaNord report is a summary of the presentations and experiences shared during the three year period of the NORDIRA project. The group emphasizes a flexible food aggregation system in reporting food consumption to enable different kind of matching of data from food consumption and occurence of chemical substances

A Multi-wavelength analysis of M81: insight on the nature of Arp's loop

Context: The optical ring like structure detected by Arp (1965) around M81 (commonly referenced as "Arp's loop") represents one of the most spectacular feature observed in nearby galaxies. Arp's loop is commonly interpreted as a tail resulting from the tidal interaction between M81 and M82. However, since its discovery the nature of this feature has remained controversial. Aims: Our primary purpose was to identify the sources of optical and infrared emission observed in Arp's loop. Methods: The morphology of the Arp's loop has been investigated with deep wide-field optical images. We also measured its colors using IRAS and Spitzer-MIPS infrared images and compared them with those of the disk of M81 and Galactic dust cirrus that fills the area where M81 is located. Results: Optical images reveal that this peculiar object has a filamentary structure characterized by many dust features overlapping M81's field. The ratios of far-infrared fluxes and the estimated dust-to-gas ratios indicate the infrared emission of Arp's loop is dominated by the contribution of cold dust that is most likely from Galactic cirrus. Conclusions: The above results suggest that the light observed at optical wavelengths is a combination of emission from i) a few recent star forming regions located close to M81, where both bright UV complexes and peaks in the HI distribution are found, ii) the extended disk of M81 and iii) scattered light from the same Galactic cirrus that is responsible for the bulk of the far infrared emission.Comment: 7 pages, 7 figures, accepted for publication by A&

An unfolding signifier: London's Baltic Exchange in Tallinn

In the summer of 2007 an unusual cargo arrived at Muuga and Paldiski harbors outside Tallinn. It consisted of nearly 50 containers holding over 1,000 tons of building material ranging from marble columns, staircases and fireplaces, to sculpted allegorical figures, wooden paneling and old-fashioned telephone booths. They were once part of the Baltic Exchange in the City of London. Soon they will become facets of the landscape of Tallinn. The following article charts this remarkable story and deploys this fragmented monument to analyze three issues relating to the Estonian capital: the relocation of the ‘Bronze Soldier’, the demolition of the Sakala Culture Center, and Tallinn’s future role as European Cultural Capital in 2011