471 research outputs found

    Serotonin and Schizophrenia

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    The impact of personality traits on interpersonal dynamics at zero acquaintance

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    The current study aimed to examine the relationship between personality traits and interpersonal states. Eighty undergraduate participants were administered personality trait inventories, then 40 dyads were video recorded doing collaborative tasks. These video recordings were coded for moment-to-moment communion and agency using Continuous Assessment of Interpersonal Dynamics. Actor-Partner Interdependence Modeling was used to understand the impact of personality traits on interpersonal dynamics (average, variability, slope, complementarity on agency and communion). The results showed that there were no relationships between personality traits and dynamics. There were two main limitations that may explain these results. First, behavior may have been influenced more by social norms to be friendly and take turns than personality traits, especially in this “strong situation”. Second, it may be useful to aggregate behavior over multiple situations to capture variance attributable to traits. Future studies should aggregate behavior over multiple situations and/or change the situational constraints on behavior in order to determine the relationship between states and traits

    Three-Dimensional Propagation of Magnetohydrodynamic Waves in Solar Coronal Arcades

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    We numerically investigate the excitation and temporal evolution of oscillations in a two-dimensional coronal arcade by including the three-dimensional propagation of perturbations. The time evolution of impulsively generated perturbations is studied by solving the linear, ideal magnetohydrodynamic (MHD) equations in the zero-beta approximation. As we neglect gas pressure the slow mode is absent and therefore only coupled MHD fast and Alfven modes remain. Two types of numerical experiments are performed. First, the resonant wave energy transfer between a fast normal mode of the system and local Alfven waves is analyzed. It is seen how, because of resonant coupling, the fast wave with global character transfers its energy to Alfvenic oscillations localized around a particular magnetic surface within the arcade, thus producing the damping of the initial fast MHD mode. Second, the time evolution of a localized impulsive excitation, trying to mimic a nearby coronal disturbance, is considered. In this case, the generated fast wavefront leaves its energy on several magnetic surfaces within the arcade. The system is therefore able to trap energy in the form of Alfvenic oscillations, even in the absence of a density enhancement such as that of a coronal loop. These local oscillations are subsequently phase-mixed to smaller spatial scales. The amount of wave energy trapped by the system via wave energy conversion strongly depends on the wavelength of perturbations in the perpendicular direction, but is almost independent from the ratio of the magnetic to density scale heights.Comment: 27 pages, 11 figure

    Pharmacological characterizations of the 'legal high' fluorolintane and isomers

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    1,2-Diarylethylamines represent a class of molecules that have shown potential in pain, epilepsy, neurodegenerative disease and depression. Examples include lefetamine, remacemide, and lanicemine. Recently, several 1,2-diarylethylamines including the dissociatives diphenidine, methoxphenidine and ephenidine as well as the opioid MT-45, have appeared as ‘research chemicals’ or ‘legal highs’. Due to their rapid emergence little is known about their pharmacology. One of these, 1-[1-(2-fluorophenyl)-2-phenylethyl]pyrrolidine (fluorolintane, 2-F-DPPy), is available for purchase with purported dissociative effects meant to mimic phencyclidine (PCP) and ketamine. To better understand this emerging class, pharmacological investigations were undertaken for the first time on fluorolintane and its five aryl-fluorine-substituted isomers. In vitro binding studies revealed high N-methyl-D-aspartate (NMDA) receptor affinity (Ki = 87.92 nM) and off-target affinities at several sites including norepinephrine (NET), serotonin (SERT) and dopamine (DAT) transporters, and sigma receptors. High affinities for DAT were observed, which were typically greater than NMDA receptor affinities. Additional functional and behavioral experiments show fluorolintane inhibited NMDA receptor-induced field excitatory postsynaptic potentials in rat hippocampal slices and inhibited long-term potentiation induced by theta-burst stimulation in rat hippocampal slices with potencies consistent with its NMDA receptor antagonism. Finally fluorolintane significantly inhibited prepulse inhibition in rats, a measure of sensorimotor gating, with a median effective dose (ED50) of 13.3 mg/kg. These findings are consistent with anecdotal reports of dissociative effects of fluorolintane in humans

    Toxic effects of indocyanine green, infracyanine green, and trypan blue on the human retinal pigmented epithelium

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    Background: Indocyanine green, infracyanine green, and trypan blue are frequently used as aids to visualize structures removed during vitreoretinal surgery. But they may have toxic effects on the retina. We therefore compared the acute and chronic toxicities of these stains on cultured human retinal pigmented epithelial (RPE) cells using clinically relevant concentrations and an identical experimental setup for each agent. Methods: Monolayers of RPE cells were incubated with various concentrations of indocyanine green, infracyanine green (each at 0.005%, 0.05%, and 0.5%) or trypan blue (0.05%, 0.06%, 0.1%, 0.15%, and 0.5%) for 5min (acute exposure) or 6 days (chronic exposure). Using the propidium iodide assay, acute cytotoxicity was monitored at 15-min intervals for up to 3h. Chronic cytotoxicity was assessed by monitoring cell calcein esterase activity, cell proliferation, and cell morphology (viability) after 6 days of exposure. Results: Indocyanine and infracyanine green induced acute and chronic toxicities at a concentration above 0.05%. Trypan blue evoked no acute toxicity, but it was chronically cytotoxic at all tested concentrations. Conclusions: Despite thorough rinsing after application, significant amounts of the not sufficiently water soluble indocyanine and infracyanine green are retained after surgery by the eye. Trypan blue, being more water-soluble than ICG, is probably retained to the least degree. This circumstance is fortunate given that trypan blue exhibits a chronic cytotoxicity comparable to ICG at all clinically relevant concentrations. During vitrectomy, surgeons should aim to expose retinal tissue to only low concentrations of these stains and for as short a period as possibl

    Grateful parents raising grateful children: Niche selection and the socialization of child gratitude

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    Given that children’s exposure to gratitude-related activities may be one way that parents can socialize gratitude in their children, we examined whether parents’ niche selection (i.e., tendency to choose perceived gratitude-inducing activities for their children) mediates the association between parents’ reports of their own and their children's gratitude. Parent-child dyads (N =101; children aged 6-9; 52% girls; 80% Caucasian; 85% mothers) participated in a laboratory visit and parents also completed a seven-day online diary regarding children’s gratitude. Decomposing specific indirect effects within a structural equation model, we found that parents high in gratitude were more likely to set goals to use niche selection as a gratitude socialization strategy, and thereby more likely to place their children in gratitude-related activities. Placement in these activities, in turn, was associated with more frequent expression of gratitude in children. We describe future directions for research on parents’ role in socializing gratitude in their children

    Scoping literature review and focus groups with healthcare professionals on psychosocial and lifestyle assessments for childhood obesity care

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    Background: Childhood obesity is a complex disease resulting from the interaction of multiple factors. The effective management of childhood obesity requires assessing the psychosocial and lifestyle factors that may play a role in the development and maintenance of obesity. This study centers on available scientific literature on psychosocial and lifestyle assessments for childhood obesity, and experiences and views of healthcare professionals with regard to assessing psychosocial and lifestyle factors within Dutch integrated care. Methods: Two methods were used. First, a scoping review (in PubMed, Embase, PsycInfo, IBSS, Scopus and Web of Science) was performed by systematically searching for scientific literature on psychosocial and lifestyle assessments for childhood obesity. Data were analysed by extracting data in Microsoft Excel. Second, focus group discussions were held with healthcare professionals from a variety of disciplines and domains to explore their experiences and views about assessing psychosocial and lifestyle factors within Dutch integrated care. Data were analysed using template analysis, complemented with open coding in MAXQDA. Results: The results provide an overview of relevant psychosocial and lifestyle factors that should be assessed and were classified as child, family, parental and lifestyle (e.g. nutrition, physical activity and sleep factors) and structured into psychological and social aspects. Insights into how to assess psychosocial and lifestyle factors were identified as well, including talking about psychosocial factors, lifestyle and weight; the professional-patient relationship; and attitudes of healthcare professionals. Conclusions: This study provides an overview of psychosocial and lifestyle factors that should be identified within the context of childhood obesity care, as they may contribute to the development and maintenance of obesity. The results highlight the importance of both what is assessed and how it is assessed. The results of this study can be used to develop practical tools for facilitating healthcare professionals in conducting a psychosocial and lifestyle assessment.</p

    The Lantern Vol. 4, No. 2, March 1936

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    • Cooperative Democracy • Fantasy • Drama: Porgy and Bess • Foreign Entanglements • The Kibitzer • My Gallery of Old Folks • My Friend, Mark Twain • Jimmy and Waffles • Reminiscence • Gold Dust • After Twenty Centuries • All the World\u27s a Stage • Early Medicinehttps://digitalcommons.ursinus.edu/lantern/1007/thumbnail.jp
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