Papillary cystadenoma of the parotid gland: A case report.

BackgroundPapillary cystadenoma is a rare benign epithelial tumor of the salivary gland, which is characterized by papillary structures and oncocytic cells with rich eosinophilic cytoplasm. We found only one case of papillary cystadenoma in nearly 700 cases of salivary gland tumors. Our case was initially mistaken for a tumor of the right temporomandibular joint (TMJ) capsule rather than of parotid gland origin. Preoperative magnetic resonance imaging (MRI) and computed tomography (CT) should be carefully studied, which allows for appropriate preoperative counseling and operative planning.Case summaryHere, we report an unusual case of a 54-year-old woman with a parotid gland papillary cystadenoma (PGPC) that was misdiagnosed as a tumor of the right TMJ capsule. She was initially admitted to our hospital due to a mass anterior to her right ear inadvertently found 5 d ago. Preoperative CT and MRI revealed a well circumscribed tumor that was attached to the right TMJ capsule. The patient underwent a resection through an incision for TMJ, but evaluation of an intraoperative frozen section revealed a benign tumor of the parotid gland. Then we removed part of the parotid gland above the temporal facial trunk. The facial nerve was preserved. Postoperative histopathological findings revealed that the tumor was PGPC. No additional treatment was performed. There was no recurrence during a 20-mo follow-up period.ConclusionThe integrity of the interstitial space around the condyle in MRI or CT should be carefully evaluated for parotid gland or TMJ tumors

Adenoid cystic carcinoma: emerging role of translocations and gene fusions.

Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease. Due to high long-term mortality and lack of effective systemic treatment, the slow-growing but aggressive ACC poses a particular challenge in head and neck oncology. Despite the advancements in cancer genomics, up until recently relatively few genetic alterations critical to the ACC development have been recognized. Although the specific chromosomal translocations resulting in MYB-NFIB fusions provide insight into the ACC pathogenesis and represent attractive diagnostic and therapeutic targets, their clinical significance is unclear, and a substantial subset of ACCs do not harbor the MYB-NFIB translocation. Strategies based on detection of newly described genetic events (such as MYB activating super-enhancer translocations and alterations affecting another member of MYB transcription factor family-MYBL1) offer new hope for improved risk assessment, therapeutic intervention and tumor surveillance. However, the impact of these approaches is still limited by an incomplete understanding of the ACC biology, and the manner by which these alterations initiate and drive ACC remains to be delineated. This manuscript summarizes the current status of gene fusions and other driver genetic alterations in ACC pathogenesis and discusses new therapeutic strategies stemming from the current research

MEMS 411 Final Report - Plate Pourer II

The objective of this project is to create a machine that has the capability to pour Petri dishes. The usage of this machine must be easier than simply performing the task by hand, be automated, capable of producing 120 plates per hour, be sterile, prevent the plates from sloshing, fit in a fume hood, and stack the plates while they are cooling so that they may cool properly. This all was accomplished with a device that drops the plates vertically down, fills them, and then lowers them into storage thanks to their now increased mass and a spring-loaded platform

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor.

Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that promote cellular proliferation and survival. Previous studies have demonstrated antitumor activity of CS3D in preclinical models of solid tumors. However, prior to entering human clinical trials, the efficiency of generating the CS3D molecule and its stability in biological fluids should be determined. CS3D is synthesized as a single-stranded ODN and must have its free ends ligated to generate the final cyclic form. In this study, we report a ligation efficiency of nearly 95 percent. The ligated CS3D demonstrated a half-life of 7.9 h in human serum, indicating adequate stability for intravenous delivery. These results provide requisite biochemical characterization of CS3D that will inform upcoming clinical trials

The effect of stimulation frequency on the transmural ventricular monophasic action potential in yellowfin tuna Thunnus albacares

Monophasic action potentials (MAPs) were recorded from the spongy and compact layers of the yellowfin tuna Thunnus albacares ventricle as stimulation frequency was increased. MAP duration decreased with increase in stimulation frequency in both the spongy and compact myocardial layers, but no significant difference in MAP duration was observed between the layers

Calibration to Mitigate Near-Field Antennas Effects for a MIMO Radar Imaging System

A calibration method for a high-resolution hybrid MIMO turntable radar imaging system is presented. A line of small metal spheres is employed as a test pattern in the calibration process to measure the position shift caused by undesired antenna effects. The unwanted effects in the antenna near-field responses are analysed, modelled and significantly mitigated based on the symmetry and differences in the responses of the MIMO configuration

Near-Field Propagation Analysis for Vivaldi Antenna Design: Insight Into the Propagation Process for Optimizing the Directivity, Integrity of Signal Transmission, and Efficiency

Refined optimization of complex curve–linear-shaped radiators, such as traveling-wave Vivaldi antennas, can be achieved by considering simulated near fields to interpret in detail the structural influences of a design. The relationships between the space and time distributions of electromagnetic (EM) energy clusters and the geometric features are revealed with appropriate use of impulse response analysis combined with the multiple signal classification (MUSIC) algorithm. This article reports a deeper approach when applied to the adjustment of the geometric features of a traveling-wave antenna based on an analysis of near-field propagation features

Millimetre-wave Planar Bruce Array Antenna

A tri-band mm-wave planar Bruce array antenna for fifth generation communications (5G) is presented. The 16-element planar Bruce array antenna is simulated and fabricated on Rogers RT/Duroid 5880 substrate with thickness of 0.254 mm. For a compact and simple structure, the antenna has a highly directional fan-beam radiation pattern at broadside and peak realized gain of 14.0 dBi

Calibration for a hybrid MIMO near-field imaging system to mitigate antennas effects

A calibration method for a high-resolution hybrid MIMO turntable radar imaging system is presented. A line of small metal balls is used in the calibration process to measure the position shift caused by undesired effects of the antennas. The unwanted effects in the near-field antenna response are analysed and significantly mitigated based on the referential features of the MIMO configuration

Ka-band Vivaldi Antenna with Novel Core Element for High-Gain

A high gain Vivaldi antenna employing an integrated core element is proposed. The maximum antenna gain is 16.9 dBi and it performs better than 14 dBi over the complete Ka (24 - 40 GHz) band. The design methodology, excitation arrangement and field distribution features are described