Stated Preferences of Physicians and Chronic Pain Sufferers in the Use of Classic Strong Opioids

AbstractWe conducted a two-stage study in France, Germany, Italy, Spain, Sweden, and the United Kingdom of the stated preferences of chronic pain sufferers treated with classic strong opioids and of physicians treating such patients. The qualitative stage identified attributes perceived important through focus groups with 84 pain sufferers and semistructured interviews with 11 physicians. The quantitative stage included online, discrete choice experiments (DCEs) in which respondents chose between hypothetical profiles or an opt-out in 15 choice tasks. The profile descriptions were based on the attributes elicited in the qualitative stage. DCEs were conducted for pain sufferers (N = 242) and physicians (N = 270) who passed a rationality test. Main-effects models were estimated by hierarchical Bayesian regression. Sufferers ranked nausea, pain impact, energy, alertness, and constipation; physicians ranked pain response, central nervous system (CNS) effects, nausea, dose form, and constipation in descending order of importance. Sufferers were unwilling to incur severe side effects to decrease pain and chose the opt-out in approximately one half of the choice tasks, whereas physicians were willing to trade between profiles. The models predicted physicians' choices better than those of pain sufferers. No age, sex, or country effects were seen, but stronger preferences were found among physicians treating noncancer (n = 40) than cancer pain and among the 55% of sufferers who had never discontinued long-term pain medication use. Sufferers' mean pain scores on an 11-point Likert scale were 4.0, 5.7, and 8.6 on their best, average, and worst days, respectively

Matrix theory of gravitation

A new classical theory of gravitation within the framework of general relativity is presented. It is based on a matrix formulation of four-dimensional Riemann-spaces and uses no artificial fields or adjustable parameters. The geometrical stress-energy tensor is derived from a matrix-trace Lagrangian, which is not equivalent to the curvature scalar R. To enable a direct comparison with the Einstein-theory a tetrad formalism is utilized, which shows similarities to teleparallel gravitation theories, but uses complex tetrads. Matrix theory might solve a 27-year-old, fundamental problem of those theories (sec. 4.1). For the standard test cases (PPN scheme, Schwarzschild-solution) no differences to the Einstein-theory are found. However, the matrix theory exhibits novel, interesting vacuum solutions.Comment: 24 page

Thermal Infrared Imaging Experiments of C-Type Asteroid 162173 Ryugu on Hayabusa2

The thermal infrared imager TIR onboard Hayabusa2 has been developed to investigate thermo-physical properties of C-type, near-Earth asteroid 162173 Ryugu. TIR is one of the remote science instruments on Hayabusa2 designed to understand the nature of a volatile-rich solar system small body, but it also has significant mission objectives to provide information on surface physical properties and conditions for sampling site selection as well as the assessment of safe landing operations. TIR is based on a two-dimensional uncooled micro-bolometer array inherited from the Longwave Infrared Camera LIR on Akatsuki (Fukuhara et al., 2011). TIR takes images of thermal infrared emission in 8 to 12 μm with a field of view of 16×12∘ and a spatial resolution of 0.05∘ per pixel. TIR covers the temperature range from 150 to 460 K, including the well calibrated range from 230 to 420 K. Temperature accuracy is within 2 K or better for summed images, and the relative accuracy or noise equivalent temperature difference (NETD) at each of pixels is 0.4 K or lower for the well-calibrated temperature range. TIR takes a couple of images with shutter open and closed, the corresponding dark frame, and provides a true thermal image by dark frame subtraction. Data processing involves summation of multiple images, image processing including the StarPixel compression (Hihara et al., 2014), and transfer to the data recorder in the spacecraft digital electronics (DE). We report the scientific and mission objectives of TIR, the requirements and constraints for the instrument specifications, the designed instrumentation and the pre-flight and in-flight performances of TIR, as well as its observation plan during the Hayabusa2 mission

FK506 protects against articular cartilage collagenous extra-cellular matrix degradation

Objective: Osteoarthritis (OA) is a non-rheumatologic joint disease characterized by progressive degeneration of the cartilage extra-cellular matrix (ECM), enhanced subchondral bone remodeling, activation of synovial macrophages and osteophyte growth. Inhibition of calcineurin (Cn) activity through tacrolimus (FK506) in invitro monolayer chondrocytes exerts positive effects on ECM marker expression. This study therefore investigated the effects of FK506 on anabolic and catabolic markers of osteoarthritic chondrocytes in 2D and 3D invitro cultures, and its therapeutic effects in an invivo rat model of OA. Methods: Effects of high and low doses of FK506 on anabolic (QPCR/histochemistry) and catabolic (QPCR) markers were evaluated invitro on isolated (2D) and ECM-embedded chondrocytes (explants, 3D pellets). Severe cartilage damage was induced unilaterally in rat knees using papain injections in combination with a moderate running protocol. Twenty rats were treated with FK506 orally and compared to twenty untreated controls. Subchondral cortical and trabecular bone changes (longitudinal microCT) and macrophage activation (SPECT/CT) were measured. Articular cartilage was analyzed exvivo using contrast enhanced microCT and histology. Results: FK506 treatment of osteoarthritic chondrocytes invitro induced anabolic (mainly collagens) and reduced catabolic ECM marker expression. In line with this, FK506 treatment clearly protected ECM integrity invivo by markedly decreasing subchondral sclerosis, less development of subchondral pores, depletion of synovial macrophage activation and lower osteophyte growth. Conclusion: FK506 protected cartilage matrix integrity invitro and invivo. Additionally, FK506 treatment invivo reduced OA-like responses in different articular joint tissues and thereby makes Cn an interesting target for therapeutic intervention of OA

The High Energy Telescope for STEREO

The IMPACT investigation for the STEREO Mission includes a complement of Solar Energetic Particle instruments on each of the two STEREO spacecraft. Of these instruments, the High Energy Telescopes (HETs) provide the highest energy measurements. This paper describes the HETs in detail, including the scientific objectives, the sensors, the overall mechanical and electrical design, and the on-board software. The HETs are designed to measure the abundances and energy spectra of electrons, protons, He, and heavier nuclei up to Fe in interplanetary space. For protons and He that stop in the HET, the kinetic energy range corresponds to ∼13 to 40 MeV/n. Protons that do not stop in the telescope (referred to as penetrating protons) are measured up to ∼100 MeV/n, as are penetrating He. For stopping He, the individual isotopes 3He and 4He can be distinguished. Stopping electrons are measured in the energy range ∼0.7–6 MeV

Generalized parton distributions and double distributions for q q-bar pions

We consider two simple covariant models for pions (one with scalar and the other with spin-1/2 constituents). Pion generalized parton distributions are derived by integration over the light-cone energy. The model distributions are consistent with all known properties of generalized parton distributions, including positivity. We also construct the corresponding double distributions by appealing to Lorentz invariance. These ostensibly constructed double distributions lead to different generalized parton distributions that need not respect the positivity constraints. This inconsistency arises from the ambiguity inherent in defining double distributions in a one-component formalism (even in the absence of the Polyakov-Weiss term). We demonstrate that the correct model double distributions can be calculated from non-diagonal matrix elements of twist-two operators.Comment: 10 pages, 7 figures, RevTex4, reference added, typos correcte

Magnetic properties of the quantum spin-1/2 XX diamond chain: The Jordan-Wigner approach

The Jordan-Wigner transformation is applied to study magnetic properties of the quantum spin-1/2 $XX$ model on the diamond chain. Generally, the Hamiltonian of this quantum spin system can be represented in terms of spinless fermions in the presence of a gauge field and different gauge-invariant ways of assigning the spin-fermion transformation are considered. Additionally, we analyze general properties of a free-fermion chain, where all gauge terms are neglected and discuss their relevance for the quantum spin system. A consideration of interaction terms in the fermionic Hamiltonian rests upon the Hartree-Fock procedure after fixing the appropriate gauge. Finally, we discuss the magnetic properties of this quantum spin model at zero as well as non-zero temperatures and analyze the validity of the approximation used through a comparison with the results of the exact diagonalization method for finite (up to 36 spins) chains. Besides the $m=1/3$ plateau the most prominent feature of the magnetization curve is a jump at intermediate field present for certain values of the frustrating vertical bond.Comment: 12 pages, 9 figures, accepted for publication in Eur. Phys. J.

Dynamical spin correlations in Heisenberg ladder under magnetic field and correlation functions in SO(5) ladder

The zero-temperature dynamical spin-spin correlation functions are calculated for the spin-1/2 two-leg Heisenberg ladder in a magnetic field above the lower critical field Hc1. The dynamical structure factors are calculated which exhibit both massless and massive excitations. These modes appear in different sectors characterized by the parity in the rung direction and by the momentum in the direction of the chains. The structure factors have power-law singularities at the lower edges of their support. The results are also applicable to spin-1 Heisenberg chain. The implications are briefly discussed for various correlation functions and the pi-resonance in the SO(5) symmetric ladder model.Comment: 15 pages, 6 figures, added references; final version to appear in Phys. Rev.

FLUTE, a linac based THz source

We propose a versatile THz source named FLUTE (Ferninfrarot Linac- Und Test-Experiment) based on a 30 - 50 MeV S-band linac with bunch compressor, that aimsat not only producing high field THz pulses but also at serving as a test facility to study accelerator physics issues. This source is an important step towards the planned ultra-broadband THz to mid infrared user facility TBONE. Special emphasis is put on studies of bunch compression as a function of bunch charge (0.1-5 nC) and of different generation mechanisms of coherent radiation (CSR, CER, CTR). This paper describes the design and layout of the proposed FLUTE machine and presents results of beam dynamic calculations with the tracking programs ASTRA and CSRtrack. In addition, calculations for the achievable peak electrical field and spectral characteristics for one version of the FLUTE layout are shown

A quantum analogue of the first fundamental theorem of invariant theory

We establish a noncommutative analogue of the first fundamental theorem of classical invariant theory. For each quantum group associated with a classical Lie algebra, we construct a noncommutative associative algebra whose underlying vector space forms a module for the quantum group and whose algebraic structure is preserved by the quantum group action. The subspace of invariants is shown to form a subalgebra, which is finitely generated. We determine generators of this subalgebra of invariants and determine their commutation relations. In each case considered, the noncommutative modules we construct are flat deformations of their classical commutative analogues. Thus by taking the limit as $q\to 1$, our results imply the first fundamental theorem of classical invariant theory, and therefore generalise them to the noncommutative case.Comment: 44 pages, 3 figure